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Dr. Monica Driscoll

Distinguished Professor

Monica Driscoll received her A. B. degree in Chemistry from Douglass College in 1979 and earned a PhD in Biochemistry and Molecular Biology at Harvard University in 1985, studying molecular and genetic regulation of gene expression in a yeast model system. She pursued postdoctoral studies in the lab of Dr. Martin Chalfie at Columbia University, where she began her work on the simple animal model C. elegans, focusing on deciphering molecular mechanisms of mechanotransduction and necrotic neuronal degeneration. She joined the faculty of the Department of Molecular Biology and Biochemistry at Rutgers University in 1991, where she is currently appointed as a Distinguished Professor.  Her lab now studies the basic biology of aging with a focus molecular mechanisms of healthspan extension via genetic, chemical, and exercise interventions. Neuronal proteostasis and anti-neurodegeneration mechanisms are also major research interests. Monica was elected to the National Academy of Sciences in 2023.

 

Educational Background 
1979-1985 Harvard University, Department of Biochemistry and Molecular Biology, Ph. D.
Doctoral Thesis in the laboratory of Dr. H. Greer, Dept. of Cellular and Developmental Biology:  Regulation of Amino Acid Biosynthesis in S. cerevisiae
1975-1979 Douglass College, Rutgers University, New Brunswick, NJ
Degree:  A.B., Chemistry, summa cum laude

 

Employment History
July 2015 – present Distinguished Professor, Rutgers University, Department of Molecular Biology and Biochemistry
July, 2003 – June 2015 Professor, Rutgers University, Department of Molecular Biology and Biochemistry
July, 1997 – June 2003 Associate Professor, Rutgers University, Department of Molecular Biology and Biochemistry (tenure)
Sept., 1991 – June, 1997 Assistant Professor, Rutgers University, Department of Molecular Biology and Biochemistry
Sept., 1985 – Aug., 1991 Post-doctoral Research Fellow, Department of Biological Sciences, Columbia University.  Molecular genetic analysis of neuronal degeneration in the nematode Caenorhabditis elegans, laboratory of now Nobel Prize winner Dr. Martin Chalfie
June, 1985 – Aug., 1985 Preliminary postdoctoral work on C. elegans, Harvard University, in laboratories of Dr. Dan Stinchomb and Dr. Victor Ambros
Sept., 1975 – May, 1985 Doctoral research, Department of Biochemistry and Molecular Biology, Harvard University, with Dr. Helen Greer.  Ph.D. Thesis: Regulation of Amino Acid Biosynthesis in S. cerevisiae
June, 1979 – Aug., 1979 Women in Science Summer Research Fellow, Merck Sharp and Dohme.  Electron spin resonance studies, Dr. S. Fan

 

Academic Honors and Awards

National Academy of Sciences, elected 2023

NIA National Advisory Committee on Aging (2019-2023)

NIH Merit Award (2017-2027)

WormBook. Advisory Board; Section Editor: Metabolism, Physiology, and Aging (2015-present)

WormAtlas. Advisory Board

Election as a American Association for the Advancement of Science Fellow (2012)

NIH Study Section, Cellular and Molecular Biology of Neurodegeneration, Chair (2011-2013)

Glenn Foundation Award for Research on Biological Mechanisms of Aging (2007-2009)

Ellison Medical Foundation Senior Scholar (2004-2008)

External Advisory Board Member, IP Proteomage, European Aging Consortium (2006-2011)

External Advisory Board on Hiring, Buck Institute for Aging Research (2007)

Alfred P. Sloan Research Fellow (1993-1995)

National Institutes of Health Postdoctoral Fellowship  (1989-1990)

American Cancer Society Postdoctoral Fellowship  (1985-1988)

Muscular Dystrophy Association Postdoctoral Fellowship  (1985)

Phi Beta Kappa (1978)

 

Monica Driscoll @ Google Scholar

 

Publications
1 Wang, Y., Arnold, ML., Smart, A.J., Wang, G., Morera, A., Nguyen, K.C.,  Schweinsberg, P.J., Bai, G., Cooper, J., Hall, D.H., Driscoll, M., Grant, B.D. 2023. Large vesicle extrusions from C. elegans neurons are consumed and stimulated by glial-like phagocytosis activity of the neighboring cell. Elife Mar 2;12:e82227. doi: 10.7554/eLife.82227. PMID 36861960
2 Jeong, H., Park, J.Y., Lee, J.-H., Baik, J.-H., Kim, C-Y., Cho, J.-Y., Driscoll, M., and Paik, Y.-K.  2022. Deficiency in RCAT-1function causes dopamine metabolism-related behavioral disorders in Caenorhabditis elegans  Int. J. Mol. Sci. 23(4):2393. doi: 10.3390/ijms23042393.
3 Teterina, A.A., Coleman-Hulbert, A.L., Banse, S.A., Willis, L.H., Perez Montes, V., Lithgow, G., Driscoll, M., Phillips, P.C.  2022. Genetic diversity estimates for the Caenorhabditis Intervention Testing Program diversity panel. MicroPubl Biol. 10.17912/micropub.biology.000518.
4 Cooper, J., Guasp, R., Arnold,  M., Grant, B, and Driscoll, M. 2021. Stress-induced increases in neuronal exopher extrusion requires lipid biosynthesis, FGF and EGF RAS/ERK signaling, PNAS, 18:e2101410118  PMID: 34475208
5 Osman, H.C., et al. 2021. Caenorhabditis Intervention Testing Program: the herbicide diuron does not robustly extend lifespan in nematodes. MicroPubl Biol. PMID: 34585102
6 Onken, B., Sedore, C.A., Coleman-Hulbert, A.L.,  Hall, D. Johnson, E., Jones, E.G., Banse, S.A., Huynh, P., Guo, S.,  Xue, J., Chen, E., Harinath, G., Foulger, A.C., Chao, E.A., Hope, J., Dipa Bhaumik, D., Plummer, W.T., Inman, D., Morshead, M., Guo, M., Lithgow, G.J., Phillips, P.C., and Driscoll, M. 2021. Metformin treatment of diverse Caenorhabditis species reveals the importance of genetic background in longevity and healthspan extension outcomes. Aging Cell e13488. doi: 10.1111/acel.13488. PMID: 34837316  Science Editors Choice highlighted in “In Others Journals” section https://www.science.org/doi/10.1126/science.acz9984
7 Laranjeiro, R.; Harinath, G, Pollard, A.K., Gaffney, C.J., Deane, C.S., Vanapalli, S.A., Etheridge, T. Szewczyk, N.J., and Driscoll, M. 2021. Spaceflight affects neuronal morphology and alters transcellular degradation of neuronal debris in adult Caenorhabditis elegans. iScience. 24(2):102105. PMID: 33659873
8 Rahman, M., Edwards, H., Birze, N., Gabrilska, R., Rumbaugh, K. P., Blawzdziewicz, J., Szewczyk, N. J., Driscoll, M., and Vanapalli, S.A. 2020. NemaLife Chip: A micropillar-based microfluidic culture device optimized for aging studies on crawling C. elegans. Sci. Rep  Oct 1;10(1):16190. doi: 10.1038/s41598-020-73002-6  PMID: 33004810
9 Onken, B., Kalinava, N., and Driscoll, M. 2020. Gluoconeogenesis and PEPCK are criticalcomponents of healthy aging and Dietary restriction life extension. PLoS Genetics, 16(8):e1008982. doi: 10.1371/journal.pgen.1008982. PMID: 32841230
10 *Arnold, M.L., *Cooper, J., Grant, B.D., Driscoll, Quantitative approaches for scoring in vivo neuronal aggregate and organelle extrusion in large exopher vesicles in C. elegans. 2020. J Vis Exp. Sep 18;(163). doi: 10.3791/61368.  PMID: 33016946
11 Anna L Coleman-Hulbert 1, Erik Johnson 1, Christine A Sedore 1, Stephen A Banse 1, Max Guo 2, Monica Driscoll 3, Gordon J Lithgow 4, Patrick C Phillips. Caenorhabditis Intervention Testing Program: The Creatine Analog β-guanidinopropionic Acid Does Not Extend Lifespan in Nematodes. MicroPubl Biol. 2020.  2020:10.17912/micropub.biology.000207.doi: 10.17912/micropub.biology.000207. Epub 2020 Jan 2. PMID: 31998863
12 Morshead, M.L., Sedore, C.A., Jones, E.G., Hall, D., Plummer, W.T., Garrett, T., Lucanic, M, Guo, M., Driscoll, M., Phillips, P.C., and Lithgow, G. 2020. Caenorhabditis Intervention Testing Program: the farnesoid X receptor agonist obeticholic acid does not robustly extend lifespan in nematodes. MicroPubl Biol. 2020. May 27;2020:10.17912/micropub.biology.000257. doi: 10.17912/micropub.biology.000257.PMID: 32550518
13 Coleman-Hulbert A.L.,, Johnson E., Sedore, C.A.,. Banse S.A., Guo, M., Driscoll,. M, Lithgow G.J., Phillips, P.C. 2020. Caenorhabditis Intervention Testing Program: the creatine analog β-guanidinopropionic acid does not extend lifespan in nematodes. MicroPubl Biol. 2020;2020:10.17912/micropub.biology.000207. doi: 10.17912/micropub.biology.000207. Epub 2020 Jan 2.PMID: 31998863.
14 Abbott M, Banse SA, Melentijevic I, Jarrett CM, Ange JS, Sedore CA, Falkowski R, Blue BW, Coleman-Hulbert AL, Johnson E, Guo M, Lithgow GJ, Phillips PC, Driscoll M. A simplified design for the C. elegans lifespan machine. J Biol Methods 2020;7(4):e137. DOI: 10.14440/jbm.2020.332
15 Banse, S.A., Lucanic, M., Sedore, C.A, ColemanHulbert, A.L., Plummer, W.T., Chen, E., Kish, J.L., Hall, D., Onken, B, Presley, M.P., Jones, E.G., Blue, B.W., Garrett, T., Abbott, A., Jian Xue, J., Guo, S., Johnson, E., Foulger, A.C., Chamoli, M., Falkowski, R, Melentijevic, I., Guasp, R., Harinath, G., Huynh, P., Patel, S., Edgar, D., Jarrett, M., Guo, M., Kapahi, P., Lithgow, J.G., Driscoll, M., and Phillips, PC. 2019. Automated lifespan determination across Caenorhabditis strains and species reveals assay-specific effects of chemicals.  Geroscience Dec.: 41(6):945-960. doi: 10.1007/s11357-019-00108-9.
16 Laranjeiro, R., Harinath, G., Hewitt, J.E., Hartman, J.H., Royal, M.A., Meyer, J.N., Vanapalli, S.A., Driscoll, M. 2019. Swim exercise in C. elegans extends neuromuscular and intestinal healthspan, enhances learning ability and protects against neurodegeneration. Proc Natl Acad Sci USA. 2019 Nov 19;116(47):23829-23839. PMID:31685639. F1000 recommended.
17 Lesanpezeshki, L.,  Hewitt. J.E., Laranjeiro, R., Antebi, A., Driscoll, M., Szewczyk, N.J., Blawzdziewicz, J., Lacerda, C.M.R. and Vanapalli, S.A. 2019. Pluronic gel-based burrowing assay for rapid assessment of neuromuscular health in C. elegans. Sci Reports. Oct 23;9(1):15246. doi: 10.1038/s41598-019-51608-9. PMID:31645584
18 Wang, G., Sun, L., Reina, C.P., Song, I., Gabel, C.V., Driscoll, M. 2019. Residues in the CED-4 CARD domain can modulate non-apoptotic neuronal regeneration functions independently from apoptosis, Sci. Reports Sep 16;9(1):13315. doi: 10.1038/s41598-019-49633-9. PMID:31527664
19 R.G. Francis, N. Naim, R. Ratnappan, J. Loose, C. Mason, L. Steenberge, T.B McClendon, G. Wang, M. Driscoll, J. Yanowitz and A. Ghazi. 2019. The longevity-promoting factor, TCER-1, widely represses stress resistance and innate immunity. Nature Comm. 2019. 10:3042 (1-16) PMID:31316054  F1000 recommended as exceptional.
20 Rahman, M., Hewitt, J. E., Van-Bussel, F., Hunter, E., Blawzdziewicz, J., Szewczyk, N. S., Driscoll, M. and Vanapalli, S. A. 2018. NemaFlex: A microfluidics-based technology for measurement of muscular strength of C. elegans. Lab Chip, 18(15):2187-2201.
21 Hartman, J.H., Smith, L.L., Gordon, K.L., Laranjeiro, R., Driscoll, M., Sherwood, D.R., Meyer, J.N. 2018. Swimming exercise and transient dietary restriction in Caenorhabditis elegans promote mitochondrial maintenance and protect against chemical-induced mitotoxicity.  Sci. Reports 8(1):8359.
22 Arnold, M.L., Smart, A.J., Melentijevic, I., Driscoll, M. 2018.  Trash talk: disposal and remote degradation of neuronal garbage.  BMC Biology doi: 10.1186/s12915-018-0487-6. PMID: 29382333
23 Antikainen, H., Driscoll, M., Haspel, G, and Dobrowolski, R. 2017. TOR-mediated regulation of metabolism in aging.  Aging Cell 16:1219-1233. doi: 10.1111/acel.12689. PMID: 28971552
24 Leyva-Díaz, E., Stefanakis, N., Carrera, I., Glenwinkel, L., Wang, G., Driscoll, M., Hobert, O. 2017. pals-22, a member of an expanded C. elegans gene family, controls silencing of repetitive DNA. Genetics Aug 11. pii: genetics.300134.2017. doi: 10.1534/genetics.117.300134.
25 Lithgow, G., Driscoll, M., and Phillips, P.  2017. A long walk toward reproducibility: Lessons from tiny worms.Nature 548:387-388.  invited commentary. PMID: 28836615
26 Graf, B.L., Kamat, S., Cheong, K.Y., Komarnytsky, S., Driscoll, M., Di, R. 2017. Phytoecdysteroid-enriched quinoa seed leachate enhances healthspan and mitochondrial metabolism in Caenorhabditis elegans. J Functional Foods, 37:1–7.
27 Plummer, T.W., Harke, J., Lucanic, M. Chen, E., Bhaumik, D., Harinath, G., Coleman-Hulbert, A.L., Dumas, K.J., Onken, B., Johnson, E., Foulger, A.C., Guo, S., Crist, A.B., Presley, M.P., Xue, J., Sedore, C.A., Chamoli, M., Chang, C., Chen, M.K., Angeli, S., Royal, M., Willis, J.H., Edgar, D., Patel, S., Chao, E.A., Kamat, S., Hope, J., Ibanez-Ventoso, C., Kish, J.L., Guo, M.,  Phillips, P., Lithgow, G.J., Driscoll, M.  2017. Standardized Protocols from the Caenorhabditis Intervention Testing Program 2013-2016: Conditions and Assays used for Quantifying the Development, Fertility and Lifespan of Hermaphroditic Caenorhabditis Strains Nature Protocols Exchangedoi:10.1038/protex.2016.086
28 Lucanic, M., Plummer, WT, Chen, E., Harke, J., Foulger JC, Onken, B,  Coleman-Hulbert, AL, Dumas, KJ, Guo, S., Johnson, E., Bhaumik, D., Xue, J., Crist, AB, Presley, MP, Harinath, G., Sedore, CA, Chamoli, M., Kamat, S., Chen, MK, Angeli, S., Chang, C., Willis, JH, Edgar, D, Royal, MA, Chao, EA, Patel, S., Garrett, T., Ibanez-Ventoso, C., Hope, J., Kish, JL, Guo, M, Lithgow, GJ, Driscoll, M., Phillips, P.C., Lithgow, G. 2017.  Impact of genetic background and experimental reproducibility on identifying chemical compounds with robust longevity effects Nature Communications, 8:14256 doi 10.1038/ncomms1426. PMID: 28220799
29 Laranjeiro, R., Harinath, G., Braekman, B.P., Driscoll, M. 2017. Single C. elegans swim sessions induce key features of mammalian exercise.  BMC Biol. 15:30. doi: 10.1186/s12915-017-0368-4. PMID: 28395669
30 Melentijevic, I., Toth, M.L., Arnold, M.L., Guasp, R., Harinath, G. Nguyen, K.C., Taub, D., Parker, A., Neri, C., Gabel, C.V., Hall, D.H., and Driscoll, M. 2017. C. elegans neurons jettison protein aggregates and mitochondria under neurotoxic stress.  Nature 542:367-371. PMID: 2817824.   Selected by F1000 as of exceptional significance in its field.  (6 F1000 citations). 
31 Pégard, N., Lu, C-H. Toth, M., Driscoll, M. and Fleischer, J. 2016. Flow-Scanning Microfluidic Imaging, Advances in Microfluidics – New Applications in Biology, Energy, and Materials Sciences, Dr. Xiao-Ying Yu (Ed.), InTech, DOI: 10.5772/64707. Available from: http://www.intechopen.com/books/advances-in-microfluidics-new-applications-in-biology-energy-and-materials-sciences/flow-scanning-microfluidic-imaging
32 Herndon, L., Wolkow, C.A., Driscoll, M. and Hall, D.H. 2016. Effects of Aging on the Basic Biology and Anatomy of C. elegans; in Olsen, M. and Gill, M., eds. C. elegans and Its Use in Understanding Ageing and Longevity, Springer. Pp 9-39.
33 Ibáñez-Ventoso, C., Herrera, C., Chen, E., Motto, D., and Driscoll M. Automated analysis of C. elegans swim behavior using CeleST software. 2016. J Vis Exp. 2016 Dec 7;(118). doi: 10.3791/54359. PMID: 28060275
34 Vayndorf, E.M., Scerbak, C., Hunter, S., Neuswanger, Toth, M.L., Parker, A.J., Neri, C., Driscoll, M. and Taylor, B.E.  2016. Morphological remodeling of C. elegans neurons during aging is modified by compromised protein homeostasis NPJ Aging and Mech. Disease 16001 1-10. PMID: 27347427
35 Morsci, N., Hall, D.H., Driscoll, M., and Sheng, Z.H. 2016. Age-related phasic patterns of mitochondrial maintenance.  J Neurosci. 36:1373-85. PMID: 26818523
36 Mendenhall, A., Driscoll, M. and Brent, R. 2015. Using measures of single-cell physiology and physiological state to understand organismic aging. Aging Cell. doi: 10.1111/acel.12424. PMID: 26616110
37 Yang, H., Zhang, Y., Chen, Y.-Z., Zhang, T., Wang, X., Zhao, X., Godfroy, JI, Liang, Q, Zhang, T, Yuan,, Q., Royal, D., Royal, M., Driscoll, M., Xia, N.S., Yin, H, and Xue, D. 2015.  A unique Lysine-rich motif in phosphatidylserine receptor PSR-1 mediates recognition and removal of apoptotic cells. Nat Commun. 6:5717. PMID: 25564762
38 Pégard N.C., Toth, M.L., Driscoll, M., Fleischer, J.W. 2015. Flow-scanning optical tomography. Lab Chip. 2014 Dec 7;14(23):4447-50. PMID: 25256716
39 Scerbak, C., Vayndorf, E.,  Neri, C., Driscoll, M., Taylor, B. 2014. Insulin signaling in the aging of healthy and proteotoxically stressed mechanosensory neurons. Front Genet., 5: 212 (1-14). PMID: 25101108
40 Restif, C., Ibanez-Ventoso, C., Vora, M., Guo, S., Metaxas, D. and Driscoll, M. 2014. CeleST: Computer vision software for quantitative analysis of C. elegans swim behavior reveals novel features of locomotion. PLoS Computational Biology, 0(7):e1003702PMID: 25033081
41 Laker, R.C., Xu, P., Ryall, K., Sujkowski, A., Kenwood, B.K., Chain, K.H., Zhang, M., Hoehn, K.L., Adler, P.N., Royal, M., Driscoll, M., Wessells, RJ, Saucerman, J.J, and Yan, Z. 2014. A novel MitoTimer reporter gene for mitochondrial content, structure, stress, and damage in vivo.  J. Biol. Chem. 289:12005-15. PMID: 24644293
42 Chen, Y., Onken, B., Chen, H., Xiao, S., Liu, X., Driscoll, M., Cao, Y., Huang, Q. 2014. Mechanism of longevity extension of Caenorhabditis elegans induced by pentagalloyl glucose isolated from eucalyptus leaves. J Agric Food Chem. 62:3422-3431. PMID: 24701969
43 Kamat, S., Yeola, S., Zhang, W.-Y., Driscoll, M. and Bianchi, L. 2014. NRA-2/Nicalin regulates neuronal death by controlling surface expression of toxic C. elegans DEG/ENaCs.  J. Biol. Chem. 289:11916-11926. PMID: 24567339
44 Vora, M., Shah, M., Ostafi, S., Onken, B., Xue, J., Ni, JZ, Gu, S., and Driscoll, M. 2013. Deletion of microRNA-80 activates dietary restriction to extend C. elegans healthspan and lifespan. PLoS Genetics e1003737 PMID: 24009527
45 Chatterjee, I., Ibanez-Ventoso, C. Vijay, P., Singaravelu, G., Baldi, C., Bair, J., Ng, S., Smolyanskaya, A., Driscoll, M., Singson, A. 2013 Dramatic fertility decline in aging C. elegans males is associated with mating execution deficits rather than diminished sperm quality. Exper. Gerontol., 48(11):1156-1166. PMID: 23916839
46 Ritter, A., Shen Y., Bass, J.F., Jeyaraj, S., Deplancke, B., Mukhopadjay A, Xue, J., Driscoll, M., Heidi A. Tissenbaum, HA, Walhout, A. 2013. Complex expression dynamics and robustness in C. elegans insulin networks.  Genome Research 23:954-965. PMID: 23539137
47 Reina, C.P., Driscoll, M., and Gabel, C.V. 2013. Neuronal repair: Apoptotic proteins make good. Worm 2(2):1-6. PMID: 24058867
48 Toth, M. Melentijevic, I. Shah, L., Bhatia, A., Lu, K., Talwar, A., Naji, H., Ibanez-Ventoso, C., Ghose, P., Jevince, A., Herndon L., Bhanot, G., Rongo, C., Hall, D.H., and Driscoll, M. 2012. Neurite sprouting and synapse deterioration in the aging C. elegans nervous system.  J. Neurosci. 32: 8778-90. PMID 22745480
49 Pinan-Lucarre, B., Gabel, C., Reina, C., Hulme, S.E., Shevkoplyas, S.S., Slone, R.D., Xue, J., Weisberg, S., Whitesides, G., Samuel, A. and Driscoll, M. 2012. The core apoptotic executioner proteins CED-3 and CED-4 promote neuronal regeneration in C. elegans. PLoS Biology, 10(5):e1001331. PMID 22629231
50 Yu, S. and Driscoll, M. 2011.  EGF signaling comes of age: promotion of healthy aging in C. elegans. Exptl. Gerontol.46:129-134.
51 Restif, C.  Ibanez-Ventoso, C., Driscoll, M. and Metaxas, D. 2011. Tracking C. elegans swimming for high throughput phenotyping.  International Symposium on Biomedical Imaging 2011, pp.1542-1548, March 2011, doi: 10.1109/ISBI.2011.5872695
52 Chatzigeorgiou, M., Grundy, S., Kindt, K., Lee, W-H, Driscoll, M and Schafer, W.R. 2010. Spatial asymmetry in the mechanosensory phenotypes of the C. elegans DEG/ENaC gene mec-10.  J. Neurophys. 104:3334-3344.
53 Chatzigeorgiou, M., Yoo, S., Watson, J.D., Lee, W.-H., Clay Spencer, W., Kindt, K.S., Hwang, S.W., Miller III, D.M., Treinin, M., Driscoll, M., and Schafer, W. 2010. Specific roles for DEG/ENaC and TRP channels in mechanical and thermal sensation in C. elegans polymodal nociceptors. Nature Neurosci. 13:861-868.
54 Iwasa, H., Yu, S., Xue, J. and Driscoll, M. 2010. Novel EGF pathway regulators modulate C. elegans healthspan and lifespan via EGF receptor, PLC-γ and IP3R activation. Aging Cell 4:490-505.
55 Onken, B and Driscoll, M. 2010. Metformin induces both a dietary restriction-like state and the oxidative stress response to extend C. elegans healthspan via an AMPK, LKB1, and SKN-1-dependent mechanism. PLoS One 5:e8758, pp. 1-12.
56 Mojsilovic-Petrovic, J., Nedelsky, N., Boccitto, M., Mano, I., Georgiades, S.N. , Zhou, W., Liu, W., Neve, R.N., Taylor, J.P., Driscoll, M., Clardy, J., Merry, D. and Kalb, R.G. 2009. FOXO3a is broadly neuroprotective in vitroand in vivo against insults implicated in motor neuron diseases. J Neurosci. 29:8236-8247.
57 Ibanez-Ventoso, C. and Driscoll, M. 2009. MicroRNAs in C. elegans aging:  Molecular insurance for robustness?Curr. Genomics. 10:144-154.
58 Mano, I., Straud, S. and Driscoll, M. 2009 C. elegans glutamate transporter deletion induces AMPA-receptor/adenylyl cyclase 9-dependent excitotoxicity, J. Neurochem., 108:1373-1384.
59 Wang Y, Apicella A Jr, Lee SK, Ezcurra M, Slone RD, Goldmit M, Schafer WR, Shaham S, Driscoll M, Bianchi L. 2008. A glial DEG/ENaC channel functions with neuronal channel DEG-1 to mediate specific sensory functions in C. elegans.  EMBO J. 27:2388-2399.
60 Zhang, W., Bianchi, L., Lee, W. Wang, Y. and Driscoll, M. 2008. Inter-subunit interactions between mutant DEG/ENaCs induce synthetic neurotoxicity, Cell Death Diff. 15:1794-1803.
61 Ibanez-Ventoso, C., Vora, M. and Driscoll, M. 2008. Sequence relationships among C. elegans, D. melanogaster and human microRNAs highlight the extensive conservation of microRNAs in biology.  PLoS ONE, 3: e2818, p1-23.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2486268/
62 Blum, E.S., Driscoll, M. and Shaham, S. 2008. Noncanonical death programs in the nematode Caenorhabditis elegans.  Cell Death Diff. 7: 15:1124-1131.
63 Hansen, M., Chandra, Al, Mitic, L.L, Onken, B., Driscoll, M. and Kenyon, C.  2008.  A role for autophagy genes in the extension of lifespan by dietary restriction in C. elegans, PLoS Genetics, 4:e24, p1-14.
64 Tsechpenakis, G. Bianchi, L., Metaxis, D., Driscoll, M. 2008. A novel computational approach for simultaneous tracking and feature extraction of C. elegans populations in fluid environments. IEEE Transactions on Biomedical Engineering. 55: 1539-1549.
65 Mano, I., Straud, S. and Driscoll, M.  2007.  Glutamate clearance strategies impact behavior and learning in the C. elegans nervous system.  J. Biol. Chem J. Biol. Chem. 282: 34412-34419.
66 Tsechpenakis, G., Bianchi, L., Driscoll, M. and Metaxas, D. 2007. Tracking C. elegans populations in fluid environments for the study of different locomotory behaviors. In: 2nd. International Workshop on Microscopic Image Analysis with Applications in Biology, Piscataway, NJ.
67 Frokjaer-Jensen C, Kindt KS, Kerr RA, Suzuki H, Melnik-Martinez K, Gerstbrein B, Driscoll M, Schafer WR. 2006. Effects of voltage-gated calcium channel subunit genes on calcium influx in cultured C. elegansmechanosensory neurons.  J Neurobiol. 66: 1125-1139.
68 Bianchi, L. and Driscoll, M.  2006.  Heterologous expression of C. elegans ion channels in Xenopus oocytes  WORMBOOK http://www.wormbook.org/chapters/www_channelexpress/channelexpress.html
69 Bianchi, L. and Driscoll, M.  2006.  Culture of Embryonic C. elegans Cells for Electrophysiological and Pharmacological Analyses”.  WORMBOOK http://www.wormbook.org/chapters/www_culture/culture.html
70 Ibanez-Ventoso, C., Yang, M., Guo, S., Robins, H., Padgett, R., and Driscoll, M. 2006. Modulated microRNA expression during adult lifespan in C. elegans.   Aging Cell, 5:235-246.
71 Royal, D.C., Bianchi, L., Royal, M., Lizzio, M., Mukherjee, G., Nunez, Y. and Driscoll, M.  2005.  Temperature-sensitive mutant of the C. elegans neurotoxic MEC-4(d) DEG/ENaC channel identifies a site required for trafficking or surface maintenance.  J. Biol. Chem. 280: 41976-41986.
72 Gerstbrein, B., Stamatas, G., Kollias, N., and Driscoll, M.  2005. Analysis of in vivo autofluorescence in C. elegans identifies novel aging biomarkers that report healthspan and dietary restriction. Aging Cell 4: 127-137.
73 Bianchi, L., Gerstbrein, B., Royal, D., Xue, J. and Driscoll, M.  2004. The neurotoxic MEC-4(d) Na+ channel conducts calcium: implications for normal and aberrant activities of DEG/ENaC channels. Nature Neurosci. 7: 1337-1344.
74 Bianchi, L. and Driscoll, M.  2004.  The molecular basis of touch sensation as modeled in Caenorhabditis elegans.  in Transduction Channels in Sensory Cells.  Wiley VCH. Frings, S. and Bradley, J.  eds., pp. 1-29.
75 Driscoll, M. and Gerstbrein, B.  2003. Dying for a cause: Invertebrate genetics takes on human neurodegeneration. Nature Rev. Genet. 4: 181-194.
76 Bianchi, L., Kwok, S., Driscoll, M. and Sesti, F. 2003. A potassium channel-MiRP complex controls neurosensory function in Caenorhabditis elegans.  J. Biol. Chem. 278: 12415-12424.
77 Suzuki, H., Kerr, R., Bianchi, L., Frokjar-Jensen, C., Sloan, R., Xue, J., Gerstbrein, B., Driscoll, M. and Schafer, W.R. 2003. In vivo functional analysis of C. elegans mechanosensory neurons defines a specific role for the MEC-4 channel in gentle touch sensation. Neuron 39: 1005-1017.
78 Thieringer, H.A., Moller, B., Dodt, G., Kunau, W.-H., and Driscoll, M. 2003. Modeling the human peroxisome biogenesis disorders in the nematode Caenorhabditis elegans.  J. Cell Science 116: 1797-1804.
79 Herndon, L.A., Schmeissner, P., Dudaronek, J, Listner, K.M., Brown, P.A., Sakano, Y., Paupard, M., Hall, D. and Driscoll, M. Stochastic and genetic factors influence tissue-specific decline in ageing C. elegans. 2002. Nature419: 808-14.
80 Syntichaki, P., Xu, K., Driscoll, M., Tavernarakis, N.  2002. Specific aspartyl and calpain proteases are required for neurodegeneration in C. elegans.  Nature 419: 939-944.
81 Tavernarakis, N. and Driscoll, M.  2002. Caloric restriction, protein synthesis and aging: time to reconsider old problems with new tools?  Mech Ageing Dev. 123: 215-229.
82 Bianchi, L. and Driscoll, M. 2002. Protons at the gate: DEG/ENaCs help us feel and remember. Neuron 34: 337-340.
83 Tavernarakis, N and Driscoll, M.  2001. Degenerins:  At the core of metazoan mechanotransduction? Ann NY Acad Sci., 940: 28-41.
84 Tavernarakis, N. and Driscoll, M. 2001.  Mechanotransduction in C. elegans: the role of DEG/ENaC ion channels. Cell. Biochem. Biophys. 35: 1-18.
85 Tavernarakis, N., Everett, J. K., Kyrpides. N. and Driscoll, M.  2001. Features of the intracellular amino-termini of DEG/ENaC ion Channels.  Curr. Biol. 11: R205-R208.
86 Xu, K., Tavernarakis, N. and Driscoll, M. 2001. Necrotic cell death in C. elegans requires the function of calreticulin and regulators of Ca2+ release from the endoplasmic reticulum. Neuron 31: 957-971.
87 Herndon, L.A. and M. Driscoll.  2000.  Contributions of cell death to aging in C. elegans.  Results and Problems in Cell Differentiation, 29: 113-129.  in Molecular Biology of Aging. (ed. S. Hekimi), Springer-Verlag, Berlin.
88 Fricke, B., Lints, R., Stewart, G., Drummond, H., Dodt, G., Driscoll, M.  and v. Düring, M.  2000.  ENaC and stomatin are expressed in rat trigeminal mechanosensory neurons. Cell and Tissue Res. 299: 327-334.
89 Hong, K., Mano, I. and Driscoll, M.  2000.  Structure/function analysis of C. elegans mec-4, a component of a Na+channel required for mechanotransduction.  J. Neurosci. 20: 2575-2588.
90 Tavernarakis, N. and Driscoll, M.  2000.  Caenorhabditis elegans degenerins and vertebrate ENaC ion channels contain an extracellular domain related to venom neurotoxins.  J. Neurogenet. 13: 257-264.
91 Driscoll, M. and Tavernarakis, N.  2000. Closing in on a mammalian touch receptor.  Nature Neurosci. 3: 7-9.
92 Ledwich, D., Wu, Y.C., Driscoll, M., and Xue, D. 2000.  Methods for the study of programmed cell death in the nematode Caenorhabditis elegans. Meth. Enzymol. 322: 76-88.
93 Chung, S., Gumienny, T., Hengartner, M. and Driscoll, M. 2000. C. elegans apoptotic and necrotic cell corpses are removed by activities of a common set of engulfment genes. Nature Cell Biol. 2: 931-937.
94 Tavernarakis, N., Wang, S., Dorovokov, M., Ryazanov, A. and Driscoll, M.  2000.   Heritable and inducible genetic interference by double stranded RNA encoded by transgenes. Nature Genetics 24: 180-183.  
95 Winnier, A.R., Meir, J.Y.-J., Ross, J.M., Ishihara, I., Tavernarakis, N., Driscoll, M., and Miller, D.M., III.  1999.  UNC-4 and UNC-37-dependent repression of motor neuron-specific genes controls synaptic choice in Caenorhabditis elegans. Genes Dev. 13: 2774-2786.
96 Mano, I. and Driscoll, M. 1999.  The DEG/ENaC Channels:  A touchy superfamily that watches its salt.Bioessays 21: 568-578.
97 Tavernarakis, N., Driscoll, M. and Kyrpides, N.C. 1999. The SPFH domain: a universal motif in stomatins and other membrane-associated proteins implicated in regulating targeted protein turnover.  TiBS 24: 425-427.
98 Royal, D. and Driscoll, M.  1998.  Neuronal cell death in C. elegans.  In: Cell Death in Diseases of the Nervous System (ed. V.E. Koliatsos and R. Ratan) The Humana Press Inc., Totowa, N.J. pp. 123-144.
99 Tavernarakis, N. and Driscoll, M.  1997.  Molecular modeling of mechanotransduction in the nematode Caenorhabditis elegans.  Annu. Rev. Physiol. 59: 659-689.
100 Tavernarakis, N., Shreffler, W., Wang, S. and Driscoll, M.  1997. unc-8, a DEG/ENaC family member, encodes a subunit of a candidate mechanically-gated channel that modulates locomotion in C. elegans. Neuron 18: 107-119.
101 Hall, D.H., Gu, G., Garcia-Anoveros, J., Gong, L., Chalfie, M. and Driscoll, M.  1997.  Neuropathology of degenerative cell death in C. elegans.   J. Neurosci. 3: 1033-1045.
102 Harbinder, S., Tavernarakis, N., Herndon, L., Kinnell, M., Xu, S.Q., Fire, A. and Driscoll, M.  1997.  Genetically targeted cell disruption in Caenorhabditis elegans.  Proc. Natl. Acad. Sci USA 94: 13128-13133.
103 Driscoll, M. and Kaplan, J. 1997. Mechanotransduction, in “The Nematode C. elegans, II”.  Cold Spring Harbor Press, Cold Spring Harbor, NY., pp. 645-677.
104 Lints, R. and Driscoll, M. 1996.  Programmed and Pathological Cell Death in C. elegans.   in “Cell Aging and Cell Death”, Martin, G.R., Holbrook, N. and Lockshin, R.A., eds., Wiley-Liss, New York.  pp. 235-253.
105 Lai, C. C. Hong, K., Kinnell, M., Chalfie, M. and Driscoll, M.  1996. Sequence and transmembrane topology of MEC-4, an ion channel subunit required for mechanotransduction in C. elegans.       J. Cell Biol. 133: 1071-1081.
106 Driscoll, M. 1996.  Cell Death in C. elegans: Molecular insights into mechanisms conserved between nematodes and mammals.  Brain Path. 6: 411-425.
107 Driscoll, M.  1995.  Methods for the study of cell death in C. elegans.  Meth. Cell. Biol.  46: 323-353.
108 Driscoll, M.  1995.  Genes controlling programmed cell death:  Relation to mechanisms of cell senescence and aging?  Dahlem Workshop Reports, Molecular Aspects of Aging, John Wiley and Sons, Chichester, pp. 45-58.
109 Mariq, A.D., Peckol, E., Driscoll, M. and Bargmann, C.I.  1995.  Mechanosensory signalling in C. elegansmediated by the GLR-1 glutamate receptor.  Nature 378: 78-81.
110 Driscoll, M.  Inherited neurodegeneration in C. elegans. 1994.   in “Neurodegenerative Diseases”, Jolles, G. and Stultzmann, J.M., eds. Academic Press (London) pp. 3-22.
111 Hong, K. and Driscoll, M.  1994.  A transmembrane domain of the putative channel subunit MEC-4 influences mechanotransduction and neurodegeneration in C. elegans.  Nature 367: 470-473.
112 Mitani, S., Du, H., Hall, D., Driscoll, D. and Chalfie, M. 1993. Combinatorial control of touch receptor neuron expression in Caenorhabditis elegans. Development 19: 773-783.
113 Chalfie, M., Driscoll, M. and Huang, M.  Degenerin similarities. 1993.  Nature 361: 504.
114 Katz, L.C., Driscoll, M., Zimmerman, K. and Wiesel, T.N.  1992.  Neural development.  Brain Research Reviews 17: 171-181.
115 Driscoll, M. and Chalfie, M.  1992.  Developmental and abnormal cell death in Caenorhabditis elegans.  Trends Neurosci. 15: 15-19.
116 Driscoll, M.  1992.  Molecular genetics of cell death in C. elegans.  J. Neurobiol. 23: 1327-1351.
117 Driscoll, M. and Chalfie, M.  1991.  The mec-4 gene is a member of a family of Caenorhabditis elegans genes that can mutate to induce neuronal degeneration.  Nature 349: 558-593.
118 Kanazawa, S., Driscoll, M., and Struhl, K. 1988. ATR1, a Saccharomyces cerevisiae transmembrane protein required for aminotriazole resistance.  Mol. Cell. Biol. 8: 664-673.
119 Driscoll Penn, M., Thireos, G.  and Greer, H.  1984.   Temporal analysis of general control of amino acid biosynthesis in Saccharomyces cerevisiae:  role of positive regulatory genes in initiation and maintenance of mRNA depression. Mol. Cell. Biol. 4: 520-528.
120 Thireos, G.,  Driscoll Penn, M., and Greer, H.  1984. 5′ untranslated sequences are required for the translational control of a yeast regulatory  gene.  Proc. Natl. Acad. Sci. USA 81: 5096-5100.
121 Driscoll Penn, M., Galgoci, B. and Greer, H. 1983.  Identification of AAS genes and their regulatory role in general control of amino acid biosynthesis in yeast.  Proc. Natl. Acad. Sci. USA 80: 2704-2708.