Publications
Research Articles
Adams A.A., T.L. Wood and Kim HA. Mature and myelinating oligodendrocytes are specifically vulnerable to mild fluid percussion injury in mice. Neurotrauma Rep 2023 4(1):433-446
Adams AA, Li Y, Kim HA., Pfister BJ. Dorsal root ganglion neurons recapitulate the traumatic axonal injury of CNS neurons in response to a rapid stretch in vitro. Front Cell Neurosci. 2023 Mar 29;17:1111403. doi: 10.3389/fncel.2023.1111403. PMID: 37066078; PMCID: PMC10090399.
Kim J, Adams AA, Gokina P, Zambrano B, Jayakumaran J, Dobrowolski R, Maurel P, Pfister BJ, Kim HA. Mechanical stretch induces myelin protein loss in oligodendrocytes by activating Erk1/2 in a calcium dependent manner. Glia 68:2070-2085, 2020. doi: 10.1002/glia.23827. Epub 2020 Mar 14. PMID: 32170885. PMCID: PMC7423729.
Kim J, Elias A, Lee T, Maurel P, Kim HA. Tissue inhibitor of metalloproteinase-3 (TIMP-3) promotes Schwann cell myelination. ASN Neuro 9:1-12, 2017. doi: 10.1177/1759091417745425. PMID: 29198135. PMCID: PMC5718315.
Basak S, Desai DJ, Rho EH, Ramos R, Maurel P, Kim HA. E-cadherin enhances neuregulin signaling and promotes Schwann cell myelination. Glia 63:1522-536, 2015. doi: 10.1002/glia.22822. Epub 2015 May 19. PMID: 25988855
Kim HA, Mindos T, Parkinson DB. Plastic fantastic: Schwann cells and repair of the peripheral nervous system. Stem Cells Translational Medicine 2:553-557, 2013. doi: 10.5966/sctm.2013-0011. Epub 2013 Jul 1. PubMed PMID: 23817134. PMCID: PMC3726134.
Yang DP, Kim J, Syed N, Tung Y, Bhaskaran A, Mindos T, Mirsky R, Jessen KR, Maurel P, Parkinson DB, Kim HA. p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination. Journal of Neuroscience 32:7158-7168, 2012. doi: 10.1523/JNEUROSCI.5812-11.2012. PMID: 22623660. PMCID: PMC3369433.
Chen Y, Wang H, Yoon SO, Hottiger MO, Svaren J, Nave KA, Kim HA, Olson EN, Lu QR. HDAC-mediated deacetylation of NF-kB is critical for Schwann cell myelination. Nature Neuroscience 14:437-441, 2011. doi: 10.1038/nn.2780. Epub 2011 Mar 20. PMID: 21423191. PMCID: PMC3074381.
Syed N, Kim HA. Soluble neuregulin and Schwann cell myelination: A therapeutic potential for improving remyelination of adult axons. Molecular and Cellular Pharmacology 2:161-167, 2010. doi: 10.4255/mcpharmacol.10.22. PMID: 21274416. PMCID: PMC3026321.
Syed N, Reddy K, Yang DP, Taveggia C, Salzer JL, Maurel P, Kim HA. Soluble neuregulin-1 has bi-functional, concentration-dependent effects on Schwann cell myelination. Journal of Neuroscience 30:6122-6131, 2010. doi: 10.1523/JNEUROSCI.1681-09.2010. PMID: 20427670. PMCID: PMC2870719.
Monnerie H, Tang-Schomer MD, Iwata A, Smith DH, Kim HA, Le Roux PD. Dendritic alterations after dynamic axonal stretch injuy in vitro. Experimental Neurology 224:415-423, 2010. doi: 10.1016/j.expneurol.2010.05.001. Epub 2010 May 18. PMID: 20478308. PMCID: PMC3979358.
Tyler WA, Gangoli N, Gokina P, Kim HA, Covey M, Levison S, Wood TL. Differentiation of oligodendrocytes requires activation of mammalian target of rapamycin signaling. Journal of Neuroscience 29:6367-6378, 2009. doi: 10.1523/JNEUROSCI.0234-09.2009. PMID: 19439614. PMCID: PMC2827328.
Crawford A, Desai D, Gokina P Basak S, Kim HA. E-cadherin expression in postnatal Schwann cell is induced by activation of cAMP-dependent protein kinase A pathway. Glia 56:1637-1647, 2008. doi: 10.1002/glia.20716. PMID: 18551621. PMCID: PMC2575062.
Yang DP, Zhang DP, Mak KS, Bonder DE, Pomeroy SL, Kim HA. Schwann cell proliferation during Wallerian degeneration is not necessary for regeneration and remyelination of the peripheral nerves: axon-dependent removal of newly generated Schwann cells by apoptosis. Molecular and Cellular Neuroscience 38:80-88, 2008. doi: 10.1016/j.mcn.2008.01.017. Epub 2008 Feb 20. PMID: 18374600. PMCID: PMC2440648.
Guertin AD, Zhang DP, Mak KS, Alberta JA, Kim HA. Microanatomy of axon/glial signaling resolved in artificial sciatic nerves. Journal of Neuroscience 25:3478-3487, 2005. doi: 10.1523/JNEUROSCI.3766-04.2005. PMID: 15800203. PMCID: PMC6724908.
Gray PA, Fu H, Luo P, Zhao Q, Yu J, Ferrari A, Tenzen T, Yuk D, Tsung E, Cai Z, Alberta JA, Cheng LP, Liu Y, Stenman JM, Valerius MT, Billings N, Kim HA, McMahon AP, Rowitch DH, Stiles CD, Ma Q. Mouse Brain Organization Revealed through Direct Genome-scale TF expression analysis. Science 306:2255-2257, 2004. doi: 10.1126/science.1104935. PMID: 15618518.
Kim HA, Ratner N, Roberts TM, Stiles CD. Schwann cell proliferative responses to cAMP and Nf1 are mediated by cyclin D1. Journal of Neuroscience 21:1110-1116, 2001. PMID: 11160381. PMCID: PMC6762237.
Kim HA, Pomeroy SL, Whoriskey W, Pawlitzky I, Benowitz LI, Sicinski P, Stiles CD, Roberts TM. A developmentally regulated switch directs regenerative growth of Schwann cells through cyclin D1. Neuron 26:405-416, 2000. doi: 10.1016/s0896-6273(00)81173-3. PMID: 10839359.
Rosenbaum T, Kim HA, Boissy YL, Ling B, Ratner N. Neurofibromin, the neurofibromatosis type 1 Ras-GAP, is required for appropriate P0 expression and myelination. Annals of the New York Academy of Sciences 883:203-214, 1999. PMID: 10586246.
Rosenbaum C, Karyala S, Marchionni MA, Kim HA, Krasnoselsky AL, Happel B, Isaacs I, Brackenbury R, Ratner N. Schwann cells express NDF and SMDF/n-ARIA mRNAs, secrete neuregulin, and show constitutive activation of erbB3 receptors: evidence for a neuregulin autocrine loop. Experimental Neurology 148:604-615, 1997. doi: 10.1006/exnr.1997.6696. PMID: 9417836.
Kim HA, Ling B, Ratner N. Nf1-deficient mouse Schwann cells are angiogenic and invasive and can be induced to hyperproliferate: reversion of some phenotypes by an inhibitor of farnesyl protein transferase. Molecular and Cellular Biology 17:862-872, 1997. doi: 10.1128/mcb.17.2.862. PMID: 9001241. PMCID: PMC231813.
Kim HA, DeClue JE, Ratner N. cAMP-dependent protein kinase A is required for Schwann cell growth: interactions between the cAMP and neuregulin/tyrosine kinase pathways. Journal of Neuroscience Research 49:236-247, 1997. PMID: 9272646.
Wrabetz L, Feltri ML, Kim H, Daston M, Kamholz J, Scherer SS, Ratner N. Regulation of neurofibromin expression in rat sciatic nerve and cultured Schwann cells. Glia 15:22-32, 1995. doi: 10.1002/glia.440150104. PMID: 8847098.
Kim HA, Rosenbaum T, Marchionni MA, Ratner N, DeClue JE. Schwann cells from neurofibromin deficient mice exhibit activation of p21ras, inhibition of cell proliferation and morphological changes. Oncogene 11:325-335, 1995. PMID: 7624147.
Book Chapters
Schwann Cells. Methods in Molecular Biology, Vol. 1739, Springer Protocol, Humana Press, New York, NY. (2018). doi.org/10.1007/978-1-4939-7649-2. Editors: Paula Monje and Haesun A Kim.
Kim J and HA Kim (2018). Isolation and expansion of Schwann cells from transgenic mouse models. Chapter 3. Schwann cells. Methods in Molecular Biology, Vol. 1739. Pages 39-48. doi.org/10.1007/978-1-4939-7649-2_3.
Kim HA and Maurel P (2009). Primary Schwann cell cultures. Chapter 15. Protocols for Neural Cell Cultures. 4th Edition, Springer Protocols Handbooks, Humana Press / Springer Media, New York City, pages: 253-268. doi.org/10.1007/978-1-60761-292-6_15.
Ratner N, Williams J, Kordich JJ and Kim HA (2006). Schwann cell preparation from single mouse embryos: Analysis of neurofibromin function in Schwann cells. In Methods in Enzymology 407:22-33. doi.org/10.1016/S0076-6879(05)07003-5.
Kim HA and Ratner N (1997). A procedure for isolating Schwann cells developed for analysis of the mouse embryonic lethal mutation NF1. In: Devon RM, Doucette R, Juurlink BHJ, Nazarali AJ, Schreyer DJ, and Verge VMK (eds) Cell Biology and Pathology of Myelin: Evolving Biological Concepts and Therapeutic Approaches. Altschul Symposia Series, Vol. 4, Springer. Boston, MA. Pages 201-212. doi.org/10.1007/978-1-4615-5949-8_20.