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Publications

Peer-Reviewed Publications (*indicates senior or co-senior author)

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  1. McGraw E, Rispoli J, Horner, MB, and *Heiman GA. Undergraduate exposure to Genetic Counseling Career: A program evaluation of Rutgers Genetic Counseling Certificate Program. Journal of Genetic Counseling, Published online: https://doi.org/10.1002/jgc4.1564.
  2. Kamitaki BK, Janmohamed M, Kandula P, Elder C, Perucca P, O’Brien TJ, Lin H, *Heiman GA, and *Choi H. Clinical and electroencephalographic predictors of antiepileptic drug resistance in idiopathic generalized epilepsy: A multi-center case-control study. Epilepsia, 63:150–161, 2022. https://doi.org/10.1111/epi.17104. PMCID: N/A (not applicable). Press releases: Rutgers Today and EurekAlert!. Press release picked up by various sites, including: Rutgers Foundation, MedicalXpress, Newswise, Israel Times of News, Reach MD, and The Medical Progress.
  3. Halvorsen M, Szatkiewicz J, Mudgal P, Yu D, Psychiatric Genomics Consortium TS/OCD Working Group, Nordsletten AE, Mataix-Cols D, Mathews CA, Scharf JM, Mattheisen M, Robertson MM, McQuillin A, and Crowley JJ. Elevated common variant genetic risk for Tourette Syndrome in a densely affected pedigree. Molecular Psychiatry, 26:7522-7529, https://doi.org/10.1038/s41380-021-01277-w. 2021. PMCID: PMC Journal in Process.
  4. Abdulkadir M, Yu D, Osiecki L, King, RA, Fernandez TV, Brown LW, Cheon Keun-Ah, Coffey BJ, Garcia-Delgar B, Gilbert DL, Grice DE, Hagstrøm J, Hedderly T, Heyman I, Hong HJ, Huyser C, Ibanez-Gomez L, Kim YK, Kim YS, Koh Y, Kook S, Kuperman S, Leventhal B, Madruga-Garrido M, Maras A, Mir P, Morer A, Münchau A, Plessen KJ, Roessner V, Shin E, Song D, Song J, Visscher F, Zinner SH, Mathews CA, Scharf JM, Tischfield JA, *Heiman GA, *Dietrich A. and *Hoekstra PJ. Investigation of gene-environment interactions in relation to tic severity. Journal of Neural Transmission, 128:1757-1756, 2121. PMCID: PMC8536549.
  5. Cao X, Zhang Y, Abdulkadir M, Deng L, Fernandez TV, Garcia-Delgar B, Hagstrøm J, Hoekstra PJ, King RA, Koesterich J, Kuperman S, Morer A, Nasello C, Plessen KJ, Thackray J, Zhou L, Tourette International Collaborative Genetics Study (TIC Genetics), Dietrich A, *Tischfield JA, *Heiman GA, and *Xing J. Whole exome sequencing identifies genes associated with Tourette Disorder in multiplex families. Molecular Psychiatry, 26:6937-6951, 2021. PMCID: PMC8501157.
  6. Tsetsos F, Yu D, Sul JH, Huang AY, llmann C, Osiecki L, Darrow SM, Hirschtritt ME, Greenberg E, Muller-Vahl KR, Stuhrmann M, Dion Y, Rouleau GA, Aschauer H, Stamenkovic M, Schlögelhofer M, Sandor P, Barr CL, Grados MA, Singer HS, Nöthen MM, Hebebrand J, Hinney A, King RA, Fernandez TV, Barta C, Tarnok Z, Nagy P, Depienne C, Worbe Y, Hartmann A, Budman CL, Rizzo R, Lyon GJ, McMahon WM, Batterson JR, Cath DC, Malaty IA, Okun MS, Berlin C, Woods DW, Lee PC, Jankovic J, Robertson MM, Gilbert DL, Brown LW, Coffey BJ, Dietrich A, Hoekstra PJ, Kuperman S, Zinner SH, Wagner M, Knowles JA, Willsey AJ, Tischfield JA, Heiman GA, Cox NJ, Freimer NB, Neale BM, Davis LK, Coppola G, Mathews CA, Scharf JM, Paschou P, and on behalf of the Tourette Association of America International Consortium for Genetics, the Gilles de la Tourette GWAS Replication Initiative, the Tourette International Collaborative Genetics Study, and the Psychiatric Genomics Consortium Tourette Syndrome Working Group. Synaptic processes and immune-related pathways implicated in Tourette Syndrome. Translational Psychiatry. 56:1-12, 2021. https://doi.org/10.1038/s41398-020-01082-z. PMCID: PMC7814139.
  7. Simone L, Khan S, Ciarlariello M, Lin J, Trackman S, Heiman GA, and Ashkinadze E. Reproductive male partner testing when the female is identified to be a genetic disease carrier. Prenatal Diagnosis 41:21-27, 2021. https://doi.org/10.1002/pd.5824. PMCID: N/A (not applicable).
  8. Choi H, Detyniecki K, Bazil C, Thornton S, Crosta P, Tolba H, Muneeb M, Hirsch LJ, Heinzen EL, Sen A, Depondt C, Perucca P, *Heiman GA, and on behalf of The EPIGEN consortium. Development and validation of a predictive model of drug-resistant genetic generalized epilepsy. Neurology 95:e2150-2160 2020. DOI: https://doi.org/10.1212/WNL.0000000000010597. PMCID: PMC7713754. Press releases: Rutgers Today and EurekAlert!. Press release picked up in the following: ScienMag, Newswise, Medical Xpress, Science Daily, Devdiscourse, ANI news, Neuroscience News, The Medical News.
  9. Heiman GA, Rispoli JR, Seymour C, Leckman JF, King RA, and Fernandez, TV. Empiric recurrence risk estimates for chronic tic disorders: Implications for genetic counseling. Published online, Frontiers in Neurology, doi:10.3389/fneur.2020.00770, PMCID: PMC7432137.
  10. Cross-Disorder Group of the Psychiatric Genomics Consortium. Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell 179:1469–1482, 2019. PMCID: PMC7077032. Massachusetts General Hospital press release.
  11. Mufford M, Cheung J, Jahanshad N, van der Merwe C, Ding L, Groenewold N, Koen N, Chimusa ER, Dalvie S, Ramesar R, Knowles JA, Lochner C, Hibar, DP, Paschou P, van den Heuvel OA, Medland SE, Scharf JA, Mathews CA, Thompson PM, Stein, DJ., and Psychiatric Genomics Consortium – Tourette Syndrome working group. Concordance of genetic variation that increases risk for Tourette syndrome and that influences its underlying Neurocircuitry. Published online, Translational Psychiatry, 9:1-10, https://doi.org/10.1038/s41398-019-0452-3, 2019. PMCID: PMC6430767.
  12. Yu D, Sul JH, Tsetsos F, Nawaz MS, Huang AY, Zelaya I, Illmann C, Osiecki L, Darrow SM, Hirschtritt ME, Greenberg E, Muller-Vahl KR, Stuhrmann M, Dion Y, Rouleau G, Aschauer H, Stamenkovic M, Schlögelhofer M, Sandor P, Barr CL, Grados M, Singer HS, Nöthen MM, Hebebrand J, Hinney A, King RA, Fernandez TV, Barta C, Tarnok Z, Nagy P, Depienne C, Worbe Y, Hartmann A, Budman CL, Rizzo R, Lyon GJ, McMahon WM, Batterson JR, Cath DC,. Malaty IA, Okun MS, Berlin C, Woods DW, Lee PC, Jankovic J, Robertson MM, Gilbert DL, Brown LW, Coffey BJ, Dietrich A, Hoekstra PJ, Kuperman S, Zinner SH, Luðvigsson P, Sæmundsen E, Thorarensen Ó, Atzmon G, Barzilai N, Wagner M, Moessner R, Ophoff R, Pato CN, Pato MT, Knowles JA, Roffman JL, Smoller JW, Buckner RL, Willsey JA, Tischfield JA, Heiman GA, Stefansson H, Stefansson K, Posthuma D, Cox NJ, Pauls DL, Freimer NB, Neale BM, Davis LK, Paschou P, Coppola G, Mathews CA, Scharf JA, on behalf of the Tourette Association of America International Consortium for Genetics (TAAICG), the Gilles de la Tourette GWAS Replication Initiative (GGRI), the Tourette International Collaborative Genetics (TIC Genetics), and the Psychiatric Genomics Consortium Tourette Syndrome Working Group (PGC-TS). Interrogating the genetic determinants of Tourette syndrome and other tic disorders through genome-wide association studies. American Journal of Psychiatry 176:217-227, 2019. PMCID: PMC6677250. Massachusetts General Hospital press release. Press release picked up by: Science Daily & Medical Xpress.
  13. Abdulkadir M, Mathews CA, Scharf JM, Yu D, Tischfield JA, *Heiman GA, *Hoekstra PJ, and *Dietrich A. Polygenic risk scores derived from a Tourette syndrome GWAS predict presence of tics in the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort. Biological Psychiatry 85:289-304, 2019. PMCID: PMC6342633. Commentary by Ronald, 2019.
  14. Wang S, Mandell JD, Kumar U, Sun N, Morris MT, Arbelaez J, Nasello C, Dong S, Duhn C, Zhao X, Yang Z, Padmanabhuni SS, Yu D, King RA, Dietrich A, Khalifa M, Dahl N, Huang AY, Neale BM, Coppola G, Mathews CA, Scharf JM, Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Genetics Southern and Eastern Europe Initiative (TSGENESEE), Tourette Association of America International Consortium for Genetics (TAAICG), Fernandez TV, Buxbaum JD, Rubeis SD, Grice DE, Xing J, *Heiman GA, Tischfield JA, Paschou P, Willsey AJ and State MW. De Novo Sequence and Copy Number Variants are Strongly Associated with Tourette Disorder and Implicate Cell Polarity in Pathogenesis. Cell Reports 24:3441–3454, 2018. PMCID: PMC6475626. Rutgers press release. Medical Xpress press release. Press release picked up in the following: Medical News Today, ANC latitudes,
  15. Brainstorm consortium. Analysis of shared heritability in common disorders of the brain. Science. 2018 360:6395. pii: eaap8757. doi: 10.1126/science.aap8757. PMCID: PMC6097237. Medical Xpress press release.
  16. Insel B, Ottman R, and *Heiman GA. Mood disorders in familial epilepsy: A test of shared etiology. 59:431–439, 2018. PMCID: PMC5803440. Press releases: Wiley. Rutgers. Press release picked up in the following: EurekAlert. United Press International, Medical Xpress. News-Medical.Net. Newswise.
  17. Sun N, Nasello C, Deng L, Wang N, Zhang Y, Xu Z, Song Z, Kwan K, King RA, Pang Z, Xing J, *Heiman GA, and *Tischfield JA. The PNKD gene is associated with Tourette Disorder or Tic disorder in a multiplex family. Molecular Psychiatry, 23:1487–1495, 2018. PMCID: PMC5847395. Press release: Rutgers. Press release picked up by the following: Science Daily, Medical Xpress, EurekAlert, Health Canal.
  18. Abdulkadir M, Londono D, Gordon D, Fernandez TV, Brown LW, Cheon K, Coffey BJ, Elzerman L, Fremer C, Fründt O, Garcia-Delgar B, Gilbert DL, Grice DE, Hedderly T, Heyman I, Hong H, Huyser C, Ibanez-Gomez L, Jakubovski E, Kim Y, Kim YS, Koh Y, Kook S, Kuperman S, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Mir P, Morer A, Müller-Vahl K, Münchau A, Murphy TL, Plessen KJ, Roessner V, Shin E, Song D, Song J, Tübing J, van den Ban E, Visscher F, Wanderer S, Woods M, Zinner SH, King RA, Tischfield JA, *Heiman GA, *Hoekstra PJ, and *Dietrich A. Investigation of previously implicated genetic variants in chronic tic disorders: a transmission disequilibrium test approach. European Archives of Psychiatry and Clinical Neuroscience. 268: 301–316, 2018. PMCID: PMC5708161.
  19. Willsey AJ, Fernandez TV, Dongmei Y, King RA, Dietrich A, Xing J, Sanders SJ, Mandell JD, Huang A, Richer P, Smith L, Dong S, Samocha EK, Tourette International Collaborative Genetics (TIC Genetics), Tourette Syndrome Association International Consortium for Genetics (TSAICG), Neale BM, Coppola G, Mathews CA, Tischfield JA, *Scharf JM, *State MW, and *Heiman GA. De novo coding mutations are strongly associated with Tourette Disorder. Neuron. 94:486–499, 2017. PMCID: PMC5769876. Selected for journal cover. Press releases: Rutgers and UCSF. Press releases picked up in the following: Science Daily, Selected for “Best of Neuron 2016-2017” issue. Featured at “The Celebration of Faculty Authors and Creators”- Rutgers University Libraries.
  20. Gordon D, Londono D, Patel P, Kim W, Finch SJ, and *Heiman GA. An analytic solution to computation of power and sample size for genetic association studies under a pleiotropic mode of inheritance. Human Heredity 81:194–209, 2016. PMCID: PMC5577944.
  21. Alexander J, Potamianou H, Xing J, Deng L, Karagiannidis I, Tsetsos F, Drineas P, Tarnok Z, Rizzo R, Wolanczyk T, Farkas L, Nagy P, Szymanska Y, Androutsos C, Tsironi V, Koumoula A, Barta C, TSGeneSEE, Sandor P, Barr CL, Tischfield JA, Paschou P, *Heiman GA, and *Georgitsi M. Targeted re-sequencing approach of Gilles de la Tourette Syndrome candidate genes implicates rare potentially functional variants in Tourette Syndrome etiology. Frontiers in Neuroscience. 10:428, doi: 10.3389/fnins.2016.00428, 2016. PMCID: PMC5026935.
  22. Abdulkadir M, Tischfield JA, King RA, Fernandez TV, Brown LW, Cheon K, Coffey BJ , de Bruijn SFTM, Elzerman L, Garcia-Delgar B, Gilbert DL, Grice DE, Hagstrøm J, Hedderly T, Heyman I, Hong H, Huyser C, Ibanez-Gomez L, Kim Y, Kim YS, Koh Y, Kook S, Kuperman S, Lamerz A, Leventhal B, Ludolph AG, Madruga-Garrido M, Maras A, Messchendorp MD, Mir P, Morer A, Münchau A, Murphy TL, Openneer TJC, Plessen KJ, Rath JJG, Roessner V, Schunke O, Shin E, Sival DA, Song D, Song J, Stolte A, Tübing J, van den Ban E, Visscher F, Wanderer S, Woods M, Zinner SH, State MW, *Heiman GA, *Hoekstra PJ, and *Dietrich A. Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder. Journal of Psychiatric Research 82:126–135, 2016. PMCID: PMC5026935.
  23. Choi H, Hayat MJ, Zhang R, Hirsch LJ, Bazil C, Mendiratta A, Kato K, Javed A, Legge AW, Buchsbaum R, Resor S, and *Heiman GA. Drug resistant epilepsy in adults: outcome trajectories after failure of two medications. Epilepsia 57:1152–60, 2016. Public access policy: N/A.
  24. Sun N, Tischfield JA, King RA, and *Heiman GA. Functional evaluations of genes disrupted in patients with Tourette’s Disorder. Frontiers in Psychiatry 7:11, doi: 10.3389/fpsyt.2016.00011, 2016. PMCID: PMC4746269.
  25. Huertas-Fernández I, Gómez-Garre P, Madruga M, Bernal-Bernal I, Bonilla-Toribio M, Martín-Rodríguez JF, Cáceres-Redondo MT, Vargas-González L, Carrillo F, Pascual A, Tischfield JA, King RA, *Heiman GA, and *Mir P. GDNF gene is associated with Tourette syndrome in a family study. Movement Disorders 30:1115–1120, 2015. PMCID: PMC5036394.
  26. de Leeuw C, Goudriaan A, Smit AB, Yu D, Mathews CA, Scharf JM, Pauls DL, Illmann C, Osiecki L, Neale BM, Reus VI, Lowe TL, Freimer NB, Cox NJ, Davis LK, Rouleau GA, Chouinard S, Dion Y, Girard S, Cath DC, Posthuma D, Smit JH, Heutink P, King RA, Fernandez T, Leckman JF, Sandor P, Barr CL, McMahon W, Lyon G, Leppert M, Morgan J, Weiss R, Grados MA, Singer H, Jankovic J, Tischfield JA, Heiman GA, Verheijen MH, and Posthuma D. Involvement of astrocyte metabolic coupling in Tourette syndrome pathogenesis. European Journal of Human Genetics 23:1519–1522, 2015. PMCID: PMC4613465.
  27. Dietrich A, Fernandez TV, King RA, State MW, Tischfield JA, Hoekstra PJ, *Heiman GA, and the TIC Genetics Collaborative Group. The Tourette International Collaborative Genetics (TIC Genetics) study, finding the genes causing Tourette syndrome: objectives and methods. European Child and Adolescent Psychiatry 24:141–151, 2015. PMCID: PMC4209328.
  28. Yu D, Mathews CA, Scharf JM, Neale BM, Davis LK, Gamazon ER, Derks EM, Evans P, Edlund CK, Crane J, Fagerness JA, Osiecki L, Gallagher P, Gerber G, Haddad S, Illmann C, McGrath LM, Mayerfeld C, Arepalli S, Barlassina C, Barr CL, Bellodi L, Benarroch F, Berrió GB, Bienvenu OJ, Black DW, Bloch MH, Brentani H, Bruun RD, Budman CL, Camarena B, Campbell DD, Cappi C, Silgado JCC, Cavallini MC, Chavira DA, Chouinard S, Cook EH, Cookson MR, Coric V, Cullen B, Cusi D, Delorme R, Denys D, Dion Y, Eapen V, Egberts K, Falkai P, Fernandez T, Fournier E, Garrido H, Geller D, Gilbert DL, Girard SL, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Hardy J, Heiman GA, Hemmings SMJ, Herrera LD, Hezel DM, Hoekstra PJ, Jankovic J, Kennedy JL, King RA, Konkashbaev AI, Kremeyer B, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Lupoli S, Macciardi F, Maier W, Manunta P, Marconi M, McCracken JT, Mesa Restrepo SC, Moessner R, Moorjani P, Morgan J, Muller H, Murphy DL, Naarden AL, Nurmi E, Ochoa WC, Ophoff RA, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Romero R, Rosário MC, Rosenberg D, Ruhrmann S, Sabatti C, Salvi E, Sampaio AS, Samuels J, Sandor P, Service SK, Sheppard B, Singer HS, Smit JH, Stein DJ, Strengman E, Tischfield JA, Turiel M, Valencia Duarte AV, Vallada H, Veenstra-VanderWeele J, Walitza S, Wang Y, Weale M, Weiss R, Wendland JR, Westenberg HGM, Shugart YY, Hounie AG, Miguel EC, Nicolini H, Wagner M, Ruiz-Linares A, Cath DC, McMahon W, Posthuma D, Oostra BA, Nestadt G, Rouleau GA, Purcell S, Jenike MA, Heutink P, Hanna GL, Conti D V., Arnold PD, Freimer NB, Stewart SE, Knowles JA, Cox NJ, and Pauls DL. Cross-Disorder Genome-Wide Analyses Suggest a Complex Genetic Relationship Between Tourette’s Syndrome and OCD. American Journal of Psychiatry 172:82–93, 2015. PMCID: PMC4282594.
  29. McGrath LM, Yu D, Marshall C, Davis LK, Thiruvahindrapuram B, Li B, Cappi C, Gerber G, Wolf A, Schroeder FA, Osiecki L, O’Dushlaine C, Kirby A, Illmann C, Haddad S, Gallagher P, Fagerness JA, Barr CL, Bellodi L, Benarroch F, Bienvenu OJ, Black DW, Bloch MH, Bruun RD, Budman CL, Camarena B, Cath DC, Cavallini MC, Chouinard S, Coric V, Cullen B, Delorme R, Denys D, Derks EM, Dion Y, Rosário MC, Eapen V, Evans P, Falkai P, Fernandez TV, Garrido H, Geller D, Grabe HJ, Grados MA, Greenberg BD, Gross-Tsur V, Grünblatt E, Heiman GA, Hemmings SMJ, Herrera LD, Hounie AG, Jankovic J, Kennedy JL, King RA, Kurlan R, Lanzagorta N, Leboyer M, Leckman JF, Lennertz L, Lochner C, Lowe TL, Lyon GJ, MacCiardi F, Maier W, McCracken JT, McMahon W, Murphy DL, Naarden AL, Neale BM, Nurmi E, Pakstis AJ, Pato MT, Pato CN, Piacentini J, Pittenger C, Pollak Y, Reus VI, Richter MA, Riddle M, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Sampaio AS, Samuels J, Sandor P, Sheppard B, Singer HS, Smit JH, Stein DJ, Tischfield JA, Vallada H, Veenstra-Vanderweele J, Walitza S, Wang Y, Wendland JR, Shugart YY, Miguel EC, Nicolini H, Oostra BA, Moessner R, Wagner M, Ruiz-Linares A, Heutink P, Nestadt G, Freimer N, Petryshen T, Posthuma D, Jenike MA, Cox NJ, Hanna GL, Brentani H, Scherer SW, Arnold PD, Stewart SE, Mathews CA, Knowles JA, Cook EH, Pauls DL, Wang K, and Scharf JM. Copy number variation in obsessive-compulsive disorder and Tourette syndrome: a cross-disorder study. Journal of the American Academy of Child and Adolescent Psychiatry 53:910–919, 2014. PMCID: PMC4218748.
  30. Paschou P, Fernandez T, Sharp F *Heiman GA, and *Hoekstra PJ. Genetic susceptibility and neurotransmitters in Tourette syndrome. International Review of Neurobiology 112:155–77, 2013. PMCID: PMC4471172.
  31. Davis LK, Yu D, Keenan C, Gamazon E, Konkashbaev A, Derks EM, Neale BM, Yang J, Lee H, Evans P, Barr CL, Bellodi L, Benarroch F, Bienvenu JO, Bloch M, Blom R, Bruun RD, Budman CL, Cath DC, Cavallini MC, Chavira DA, Chouinard S, Conti DV, Cook EH, Coric V, Cullen B, Deforce D, Delorme R, Dion Y, Edlund CK, Egberts K, Falkai P, Fernandez T, Fyer AJ, Garrido H, Girard S, Grabe H, Grados MA, Greenberg BD, Gross-Tsur V, Haddad S, Heiman GA, Hemmings SMJ, Herrera LD, Illmann C, Jankovic J, Jenike MA, Kennedy JL, Kidd JR, Kidd KK, King RA, Kurlan R, Leboyer M, Leckman JF, Lennertz L, Liu C, Lochner C, Lowe TL, Macciardi F, Maier W, McCracken JT, McGrath L, Moessner R, Morgan J, Murphy DL, Naarden AL, Ophoff R, Osiecki L, Pakstis AJ, Pato CN, Pato MT, Phan N, Pittenger C, Pollak Y, Rauch SL, Renner T, Reus VI, Richter MA, Riddle MA, Robertson MM, Rosenberg D, Rouleau GA, Ruhrmann S, Ruiz-Linares A, Samuels J, Sandor P, Sheppard B, Singer H, Smit JH, State M, Stein DJ, Strengman E, Tischfield JA, Nieuwerburgh FV, Veenstra-VanderWeele J, Walitza S, Walkup J, Wang Y, Weiss R, Wendland JR, Westenberg HGM, Miguel EC, McMahon W, Wagner M, Nicolini H, Posthuma D, Hanna GL, Heutink P, Denys D, Arnold PD, Oostra BA, Nestadt G, Freimer N, Pauls DL, Wray N, Stewart SE, Mathews CA, Knowles JA, Cox NJ, and Scharf JM. Partitioning the heritability of Tourette syndrome and obsessive compulsive disorder reveals differences in genetic architecture PLOS Genetics 9(10): e1003864. doi:10.1371/journal.pgen.1003864, 2013. PMCID: PMC3812053.
  32. Moya PR, Wendland JR, Andrews AM, Rubenstein LM, Timpano KR, Heiman GA, Tischfield JA, King RA, Ramamoorthy S, McMahon FJ and Murphy DL. Common and rare gain-of-function alleles of the serotonin transporter gene, SLC6A4, associated with Tourette disorder. Movement Disorders 28:1263–70, 2013. PMCID: PMC3766488.
  33. Moya PR, Dodman NH, Timpano KR, Rubenstein LM, Rana Z, Fried RL, Reichardt LF, Heiman GA, Tischfield JA, King RA, Galdzicka M, Ginns EI, and Wendland JR. Rare missense neuronal cadherin gene (CDH2) variants in specific obsessive-compulsive disorder and Tourette disorder phenotypes. European Journal of Human Genetics 21:850–854, 2013. PMCID: PMC3722668.
  34. Scharf JM, Yu D, Mathews CA, Neale BM, Stewart SE, Fagerness JA, Evans P, Gamazon E, Edlund CK, Service SK, Tikhomirov A, Osiecki L, Illmann C, Pluzhnikov A, Konkashbaev A, Davis LK, Han B, Crane J, Moorjani P, Crenshaw AT, Parkin MA, Reus VI, Lowe TL, Rangel-Lugo M, Chouinard S, Dion Y, Girard S, Cath DC, Smit JH, King RA, Fernandez T V, Leckman JF, Kidd KK, Kidd JR, Pakstis AJ, State MW, Herrera LD, Romero R, Fournier E, Sandor P, Barr CL, Phan N, Gross-Tsur V, Benarroch F, Pollak Y, Budman CL, Bruun RD, Erenberg G, Naarden AL, Lee PC, Weiss N, Kremeyer B, Berrío GB, Campbell DD, Cardona Silgado JC, Ochoa WC, Mesa Restrepo SC, Muller H, Valencia Duarte AV, Lyon GJ, Leppert M, Morgan J, Weiss R, Grados MA, Anderson K, Davarya S, Singer H, Walkup J, Jankovic J, Tischfield JA, Heiman GA, Gilbert DL, Hoekstra PJ, Robertson MM, Kurlan R, Liu C, Gibbs JR, Singleton A, Hardy J, Strengman E, Ophoff RA, Wagner M, Moessner R, Mirel DB, Posthuma D, Sabatti C, Eskin E, Conti D V, Knowles JA, Ruiz-Linares A, Rouleau GA, Purcell S, Heutink P, Oostra BA, McMahon WM, Freimer NB, Cox NJ, and Pauls DL. Genome-wide association study of Tourette’s syndrome. Molecular Psychiatry 18:721–728, 2013. PMCID: PMC3605224.
  35. Fernandez T, Sanders S, Yurkiewicz IR, Ercan-Sencicek AG, Kim YS, Fishman D, Raubeson M, Song Y, Yasuno K, Winson H, Bilguvar K, Glessner J, Chu SH, Leckman J, King RA, Gilbert D, Heiman GA, Tischfield JA, Hoekstra PJ, Devlin B, Hakonarson H, Mane SM, Günel M, and State MW. Rare copy number variants in Tourette syndrome disrupt genes in histaminergic pathways and overlap with autism. Biological Psychiatry 71:392–402, 2012. PMCID: PMC3282144.
  36. Shanker VL, Groves, M, Heiman GA, Saunders-Pullman R, Ozelius, L, Palmese C, Raymond D, and Bressman SB. Mood and cognition in LRRK2 G2019S Parkinson’s disease. Movement Disorders 26:1875–1880, 2011. PMCID: PMC3972755.
  37. Gorroochurn P, Hodge SE, Heiman GA, and Greenberg DA. An improved delta-centralization method for population stratification. Human Heredity 71:180–185, 2011. PMCID: PMC3561693.
  38. Choi H, Heiman GA, Munger-Clary H, Etienne M, Resor SR, and Hauser WA. Seizure remission and relapse in adults with long-standing intractable epilepsy: an extended follow-up. Epilepsy Research 93:115–119, 2011. PMCID: PMC3763242.
  39. Choi H, Wong JB, Mendiratta A, Heiman GA, and Hamberger MJ. Numeracy and framing bias in epilepsy. Epilepsy & Behavior 20: 29–33, 2011. PMCID: PMC3022367.
  40. Heiman GA, Kamberakis K, Kalachikov S, Pedley TA, Hauser WA, and Ottman R. Evaluation of depression risk in LGI1 mutation carriers. Epilepsia 51:1685–1690, 2010. PMCID: PMC2939248.
  41. Ercan-Sencicek AG, Stillman AA, Ghosh A, Bilguvar K, O’Roak BJ, Mason CE, Abbott T, Gupta A, King RA, Pauls DL, Tischfield JA, Heiman GA, Singer HS, Gilbert DL, Hoekstra PJ, Loring E, Yasuno K, Fernandez T, Sanders S, Louvi A, Cho JH, Mane S, Colangelo CM, Biederer T,. Lifton RP, Gunel M and State MW. L-histidine decarboxylase and Tourette’s syndrome. New England Journal of Medicine 362:1901–8, 2010. PMCID: PMC2894694.
  42. Sanokawa-Akakura R, Cao W, Allan K, Patel K, Ganesh A, Heiman GA, Burke R, Kemp F, Bogden J, Camakaris J, Birge R, and Konsolaki M. Control of Alzheimer’s amyloid beta toxicity by the high molecular weight immunophilin FKBP52 and copper homeostasis in Drosophila. PLOS ONE 5(1): e8626. doi:10.1371/journal.pone.0008626, 2010. PMCID: PMC2801609.
  43. Choi H, Carlino RF, Heiman GA, Hauser WA, and Gilliam F. Evaluation of duration of epilepsy prior to temporal lobe epilepsy surgery during the past two decades. Epilepsy Research 86:224–227, 2009. PMCID: PMC3022376.
  44. Bressman SB, Raymond D, Fuchs T, Heiman GA, Ozelius LJ, and Saunders-Pullman R. Mutations in THAP1 (DYT6) in early-onset dystonia: a genetic screening study. Lancet Neurology 8:441–46, 2009. PMCID: PMC3712754.
  45. Logue MW, Durner M, Heiman GA, Hodge SE, Hamilton SP, Knowles JA, Fyer AJ, and Weissman MM. A linkage search for joint panic disorder/bipolar genes. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 150B:1139–1146, 2009. PMCID: PMC3058784.
  46. Heiman GA, King RA, and Tischfield JA. New Jersey Center for Tourette Syndrome sharing repository: methods and sample description. BMC Medical Genomics 1:58, 2008. URL: http://www.biomedcentral.com/1755-8794/1/58, PMCID: PMC2605751
  47. Choi H, Heiman GA, Pandis D, Cantero J, Resor SR, Gilliam FG, and Hauser WA. Seizure remission and relapse in adults with intractable epilepsy: a cohort study. Epilepsia 49:1440–1445, 2008. PMCID: PMC3684178.
  48. Raymond D, Saunders-Pullman R, de Carvalho Aguiar P, Schule B, Kock N, Friedman J, Harris J, Ford B, Frucht S, Heiman GA, Jennings J, Doheny D, Brin MF, Brin DDL, Multhaupt-Buell T, Lang AE, Kurlan R, Klein C, Ozelius LF and Bressman SB. Phenotypic spectrum and sex effects in eleven myoclonus-dystonia families with epsilon-sarcoglycan mutations. Movement Disorders 23:588–592, 2008. PMC Journal- In Process.
  49. Heiman GA, Ogburn B, Gorroochurn P, Keyes K, and Hasin, DS. Evidence for a two-stage model of dependence using the NESARC and its implications for genetic association studies. Drug and Alcohol Dependence 92:258–266, 2008. PMCID: PMC2266584.
  50. Gorroochurn P, Hodge SE, Heiman GA, and Greenberg DA. A unified approach for quantifying, testing and correcting population stratification in association studies (invited original paper). Human Heredity 64:149–159, 2007. PMCID: PMC2874730
  51. Gorroochurn P, Hodge SE, Heiman GA, Durner M, and Greenberg DA. Non-replication in association studies: “pseudo-failures” to replicate? Genetics in Medicine 9:325–331, 2007.
  52. Hess CW, Raymond D, de Carvalho Aguiar P, Frucht S, Shriberg J, Heiman GA, Kurlan R, Klein C, Bressman SB, Ozelius LF, and Saunders-Pullman R. Myoclonus-dystonia, obsessive-compulsive disorder, and alcohol dependence in SGCE mutation carriers. Neurology 68:522–524, 2007.
  53. Heiman GA, Ottman R, Saunders-Pullman R, Ozelius LJ, Risch NJ, and Bressman SB. Obsessive-compulsive disorder is not a manifestation of the DYT1 dystonia mutation. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 144B:361–364, 2007. PMCID: PMC3694482.
  54. Fyer AJ, Hamilton SP, Durner M, Haghighi F, Heiman GA, Costa R, Evrafov O, Adams P, deLeon A, Taveras N, Klein DF, Hodge SE, Weissman MM, and Knowles JA. A third-pass genome scan in panic disorder: evidence for multiple susceptibility loci. Biological Psychiatry 60:388–401, 2006.
  55. Gorroochurn P, Heiman GA, Hodge SE, and Greenberg DA. Centralizing the non-central chi-square: a new method to correct for population stratification in genetic case-control association studies. Genetic Epidemiology 30:277–289, 2006.
  56. Tsai WY, Heiman GA, and Hodge SE. Simple tests for age-at-onset anticipation: application to panic disorder. Genetic Epidemiology 28:256-260, 2005.
  57. Gorroochurn P, Hodge SE, Heiman GA, and Greenberg DA. Effect of population stratification on case-control association studies. II: false-positive rates and their limiting behavior as number of subpopulations increases. Human Heredity 58:40–48, 2004.
  58. Heiman GA, Hodge SE, Gorroochurn P, Zhang J, and Greenberg DA. Effect of population stratification on case-control association studies. I: elevation in false positive rates and comparison to confounding risk ratios (a simulation study). Human Heredity 58:30–39, 2004. Commentary: (Duane, 2005).
  59. Hamilton SP, Slager SL, de Leon AB, Heiman GA, Klein DF, Hodge SE, Weissman MM, Fyer AJ, and Knowles JA. Evidence for genetic linkage between a polymorphism in the adenosine 2A receptor (ADORA2A) and panic disorder. Neuropsychopharmacology 29:558–565, 2004.
  60. Heiman GA, Ottman R, Saunders-Pullman R, Ozelius LJ, Risch NJ, and Bressman SB. Increased risk for recurrent major depression in DYT1 dystonia mutation carriers. Neurology 63:631–637, 2004.
  61. Hamilton SP, Slager SL, Mayo D, Heiman GA, Klein DF, Hodge SE, Fyer AJ, Weissman MM, and Knowles JA. Investigation of polymorphisms in the CREM gene in panic disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 126B:111–115, 2004.
  62. Weissman MM, Gross R, Fyer, AF, Heiman GA, Gameroff MJ, Hodge SE, Kaufman D, Kaplan SA and Wickramaratne P. Interstitial cystitis and panic disorder: a potential genetic syndrome. Archives of General Psychiatry 61:273–279, 2004.
  63. Hamilton SP, Fyer AJ, Durner, M, Heiman GA, de Leon AB, Hodge SE, Knowles JA, and Weissman MM. Further genetic evidence for a panic disorder syndrome mapping to chromosome 13q. Proceedings of the National Academy of Sciences 100: 2550–2555, 2003.
  64. Ahsan H, Hodge SE, Heiman GA, Begg MD and Susser ES. Relative risk for genetic associations: the case-parent triad as a variant of case-cohort design. International Journal of Epidemiology 31:669–678, 2002.
  65. Saunders-Pullman R, Shriberg J, Heiman GA, Raymond R, Wendt K, Kramer P, Schilling K, Kurlan R, Klein C, Ozelius LJ, Risch NJ, PhD and Bressman SB. Myoclonus dystonia: possible association with obsessive-compulsive disorder and alcohol dependence. Neurology 58:242–245, 2002.
  66. Hamilton SP, Slager SL, Heiman GA, Deng Z, Haghighi F, Klein DF, Hodge SE, Weissman MM, Fyer AJ, and Knowles JA. Evidence for susceptibility locus for panic disorder near the catechol-o-methyltransferase gene on chromosome 22. Biological Psychiatry 51:591–601, 2002.
  67. Hamilton SP, Slager SL, Helleby L, Heiman GA, Klein DF, Hodge SE, Weissman MM, Fyer AJ, and Knowles JA. No association or linkage between polymorphisms in the genes encoding Cholecystokinin and the Cholecystokinin B receptor and panic disorder. Molecular Psychiatry 6:59–65, 2001.
  68. Hamilton SP, Slager SL, Heiman GA, Haghighi F, Klein DF, Hodge SE, Weissman MM, Fyer AJ, and Knowles JA. No genetic linkage or association between a functional promoter polymorphism in the Monoamine Oxidase-A gene and panic disorder. Molecular Psychiatry 5:465–466, 2000.
  69. Hamilton SP, Haghigi F, Heiman GA, Klein DF, Hodge SE, Fyer AJ, Weissman MM, and Knowles JA. Investigation of dopamine receptor (DRD4) and dopamine transporter (DAT) polymorphisms for genetic linkage or association to panic disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 96:324–330, 2000.
  70. Weissman MM, Fyer AJ, Haghigi F, Heiman GA, Deng Z, Hen R, Hodge SE, and Knowles JA. A potential panic disorder syndrome: clinical and genetic linkage evidence. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 96:24–35, 2000.
  71. Hamilton SP, Heiman GA, Haghigi F, Mick S, Klein DF, Hodge SE, Weissman MM, Fyer AJ, and Knowles JA. Lack of genetic linkage or association between a functional serotonin transporter polymorphism and panic disorder. Psychiatric Genetics 9:1–6, 1999.
  72. Nygaard TG, Raymond D, Chen C, Nishino I, Greene PE, Jennings D, Heiman GA, Klein C, Saunders-Pullman RJ, Kramer P, Ozelius LJ, and Bressman SB. Localization of a gene for myoclonus-dystonia to chromosome 7q21-q31. Annals of Neurology 46:794–798, 1999.
  73. Knowles JA, Fyer AJ, Vieland VJ, Weissman MM, Hodge SE, Heiman GA, Haghighi F, de Jesus GM, Rassnick H, Preud’homme-Rivelli X, Austin T, Cunjak J, Mick S, Fine LD, Woodley KA, Das K, Maier W, Adams PB, Freimer NB, Klein DF, and Gilliam TC. Results of a genome-wide genetic screen for panic disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 81:139–147, 1998.
  74. Almasy L, Bressman SB, Raymond D, Kramer P, Greene PE, Heiman GA, Ford B, Yount BA, de Leon D, Chouinard S, Saunders-Pullman R, Brin MF, Kapoor RP, Jones AC, Shen H, Fahn S, Risch NJ, and Nygaard TG. Idiopathic torsion dystonia linked to chromosome 8 in two Mennonite families. Annals of Neurology 42:670–673, 1997.
  75. Bressman SB, Warner TT, Almasy L, Uitti RJ, Greene PE, Heiman GA, Raymond D, Ford B, de Leon D, Fahn S, Kramer P, Risch NJ, Maraganore DM, Nygaard TG, and Harding AE. Exclusion of the DYT1 locus in familial torticollis. Annals of Neurology 40:681–684, 1996.
  76. Heiman GA, Hodge SE, Wickramaratne P, and Hsu H. Age-at-interview bias in anticipation studies: computer simulations and an example with panic disorder. Psychiatric Genetics 6:61–66, 1996.
  77. Bressman SB, Hunt A, Heiman GA, Brin MF, Burke R, Fahn S, Trugman J, DeLeon D, Kramer P, Wilhelmsen K, and Nygaard T. Exclusion of the DYT1 locus in a non-Jewish family with early-onset Dystonia. Movement Disorders 9:626–632, 1994.
  78. Kramer P, Heiman GA, Gasser T, Ozelius L, DeLeon D, Brin MF, Burke R, Hewett J, Hunt A, Moskowitz CB, Nygaard T, Wilhelmsen K, Fahn S, Breakefield XO, Risch NJ, and Bressman SB. The DYT1 gene on 9q34 is responsible for most cases of early limb-onset idiopathic torsion dystonia in non-Jews. American Journal of Human Genetics 55:468–475, 1994.
  79. Bressman SB, Heiman GA, Nygaard T, Ozelius L, Hunt A, Brin MF, Gordon M, Moskowitz CB, DeLeon D, Burke R, Fahn S, Risch N, Breakefield XO, and Kramer P. A study of idiopathic torsion dystonia in a non-Jewish family: Evidence for genetic heterogeneity. Neurology 44:283–287, 1994.
  80. Nygaard TG, Takahashi H, Heiman GA, Snow BJ, Fahn S, and Calne DB. Long-term treatment response and fluorodopa positron emission tomographic scanning of parkinsonism in a family with dopa-responsive dystonia. Annals of Neurology 32:603–608, 1992.