Resources

Transporter Proteomics

The UNC-Chapel Hill Quantitative Targeted Proteomics (QTAP) Core specializes in the targeted quantification of peptides, and therefore transporter proteins, in biological matrices using LC-MS/MS. The analytical techniques employed by the core are nano- or microLC coupled to triple quadrupole mass spectrometry. We operate an M-Class Acquity coupled to a Triple Quadrupole 7500.

Email Dr. John Fallon at jfallon@email.unc.edu for more information. Website: https://tarheels.live/qtapcore/ 

 

RESOLUTE

 

 

The RESOLUTE (Research Empowerment on Solute Carriers) project is a public-private partnership focused on intensifying global research on the human solute carrier (SLC) gene family to establish them as viable targets for drug discovery. The project provides an open-access knowledgebase and comprehensive datasets, including metabolic mapping and protein interactomes, to accelerate the functional characterization of these SLC transporters. Website: https://re-solute.eu/

 

Placenta Histology

The anatomy of the placenta is important in determining key functions. This wiki page by Dr Mark Hill introduces the histology of the placenta, the placental cord, and fetal membranes.

ToxiVerse

ToxiVerse is an online chemical data analysis portal where users can profile chemicals for in vitro bioassay responses and perform common cheminformatic analyses such as Quantiative Structure-Activity Relationship modeling, visualize chemicals space, and more.

Website: http://toxiverse.com/ 

MPRINT

The Maternal and Pediatric Precision in Therapeutics (MPRINT) Hub serves as a national resource for expertise in maternal and pediatric pharmacology, dedicated to fostering research in obstetrics, lactation, and pediatrics. By integrating data, modeling, and real-world evidence, the project aims to bridge critical knowledge gaps and advance precision medicine for maternal and pediatric populations. Website: https://www.mprint.org/ 

VARIDT

VARIDT (Variability of Drug Transporter Database) is a comprehensive resource that integrates the multilevel distribution, structural, and regulatory variability of human drug transporters and provides detailed data on their tissue-specific expression, genetic polymorphisms, and environmental factors. Website: https://idrblab.org/varidt/

DrugMAP

DrugMAP (Molecular Atlas and Pharma-information of drugs) is a comprehensive resource that systematically maps the interactions between over 30,000 drugs and pharmacologically critical molecules, including interactions with human drug transporters (DTPs) and their tissue-specific expression patterns. By integrating these drug-transporter interactions with ADME-relevant profiling across various organs and disease sites, the database provides a framework for clarifying pharmacokinetic mechanisms and accelerating AI-driven drug discovery. Website: https://drugmap.idrblab.net/

 

TransPortal

The UCSF-FDA TransPortal is a publicly accessible database that provides manually curated information on the interactions between mammalian membrane transporters and xenobiotics, including pharmaceuticals and environmental chemicals. Developed through a collaboration between UCSF and the FDA, it serves as a central resource for pharmacokinetic data, tissue-specific expression levels, and structural details to support drug development and regulatory research. Website: https://transportal.compbio.ucsf.edu/