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Publications

  1. V. I. Walters, A. L. Kwansa, J. W. Freeman, “Design and analysis of braid-twist collagen scaffolds”, Connective Tissue Research. 2012; 53(3): 255-266. 
  2. J. Freeman, V. I. Walters, A. L. Kwansa, “Ligaments, biomaterials, and tissue-engineering opportunities”. In J. O. Hollinger (Ed.), An Introduction to Biomaterials, 2nd Edition. Boca Raton, FL:Taylor & Francis Group, 2012 (Chapter 32, pp. 565-582). 
  3. K. D. McKeon-Fischer, D. H. Flagg, J. W. Freeman, “Poly(acrylic acid)/poly(vinyl alcohol) compositions coaxially electrospun with poly(ɛ-caprolactone) and multi-walled carbon nanotubes to create nanoactuating scaffolds”, Polymer. 2011 Sept 29; 52(21):4736-4743. 
  4. K.D.McKeon-Fischer, D. H. Flagg, J. W. Freeman, “Coaxial electrospun poly(ε-caprolactone), multiwalled carbon nanotubes, and polyacrylic acid/polyvinyl alcohol scaffold for skeletal muscle tissue engineering”, Journal of Biomedical Materials Research Part A. 2011 Sept 12; 99A(3):493-499. 
  5. J. W. Freeman,Y. M. Empson, E. C. Ekwueme, D. M. Paynter, P. G. Brolinson, “Effect of prolotherapy on cellular proliferation and collagen deposition in MC3T3-E1 and patellar tendon fibroblast populations”, Translational Research. 2011 Sept; 158(3):132-139. 
  6. K. D. McKeon-Fischer, J. W. Freeman, “Characterization of electrospun poly(L-lactide) and gold nanoparticle composite scaffolds for skeletal muscle tissue engineering”, Journal of Tissue Engineering and Regenerative Medicine. 2011 July; 5(7):560-568. 
  7. T. Andric, L. D. Wright, J. W. Freeman, “Rapid mineralization of electrospun scaffolds for bone tissue engineering”, Journal of Biomaterials Science, Polymer Edition. 2011 April 1; 22(11):1535-1550. 
  8. J.W. Freeman, M. D. Woods, D. A. Cromer, E. C. Ekwueme, T. Andric, E. A. Atiemo, C. H. Bijoux, C. T. Laurencin, “Evaluation of a hydrogel-fiber composite for ACL tissue engineering”, Journal of Biomechanics. 2011 Feb 24; 44(4):694-699. 
  9. T. Andric, A. C. Sampson, J. W. Freeman, “Fabrication and characterization of electrospun osteon mimicking scaffolds for bone tissue engineering”, Materials Science and Engineering C. 2011 Jan 1; 31(1):2-8. 
  10. C. S. Szot, C. F. Buchanan, P. Gatenholm, M. N. Rylander, J. W. Freeman, “Investigation of cancer cell behavior on nanofibrous scaffolds”, Materials Science and Engineering C. 2011 Jan 1; 31(1):37-42. 
  11. L. D. Wright, T. Andric, J. W. Freeman, “Utilizing NaCl to increase the porosity of electrospun materials”, Materials Science and Engineering C. 2011 Jan 1; 31(1):30-36. 
  12. A. L. Kwansa, Y. M. Empson, E. C. Ekwueme, V. I. Walters, J. W. Freeman, C. T. Laurencin, “Novel matrix based anterior cruciate ligament (ACL) regeneration”, Soft Matter. 2010 Oct 21; 6(20):5016-25. 
  13. L. D. Wright, R. T. Young, T. Andric, J. W. Freeman, “Fabrication and mechanical characterization of 3D electrospun scaffolds for tissue engineering”, Biomedical Materials. 2010 Sept 15; 5(5):055006. 
  14. A. L. Kwansa, J. W. Freeman, “Elastic energy storage in an unmineralized collagen type I molecular model with explicit solvation and water infiltration”, Journal of Theoretical Biology. 2010 Feb 21; 262(4):691-7. 
  15. K. D. McKeon, A. Lewis, J. W. Freeman, “Electrospun poly(D,Llactide) and polyaniline scaffold characterization”, Journal of Applied Polymer Science. 2010 Feb 5; 115(3):1566-72. 
  16. J. W. Freeman, M. D. Woods, D. A. Cromer, L. D. Wright, C. T. Laurencin,”Tissue engineering of the anterior cruciate ligament: The viscoelastic behavior and cell viability of a novel braid-twist scaffold”, Journal of Biomaterials Science, Polymer Edition. 2009 Aug 1; 20(12):1709-1728. 
  17. J.W. Freeman, A. L. Kwansa, “Recent advancements in ligament tissue engineering: The use of various techniques and materials for ACL repair”, Recent Patents on Biomedical Engineering. 2008; 1(1):18-23. 
  18. J. W. Freeman, L. D. Wright, C. T. Laurencin, S. Bhattacharyya,”Nanofabrication Techniques”. Chapter 1, Biomedical Nanostructures”, John Wiley & Sons, 2007 Oct 26. 
  19. J. W. Freeman, M. D. Woods, C. T. Laurencin, “Tissue engineering of the anterior cruciate ligament using a braid-twist scaffold design”, Journal of Biomechanics. 2007; 40:2029-2036. 
  20. W. J. Landis, F. H. Silver, J. W. Freeman, “Collagen as a scaffold for biomimetic mineralization of vertebrate tissues”, J. Mater. Chem. 2006; 16:1495-1503. 
  21. C. T. Laurencin, J. W. Freeman, “Ligament Tissue Engineering: An Evolutionary Materials Science Approach”, Biomaterials. 2005 Dec; 26(36):7530-6. 
  22. F. H. Silver, J. W. Freeman, G. Bradica, “Structure and Function of Ligaments, Tendons and Joint Capsule”. Chapter 2, Orthopedic Biology and Medicine Series: Repair and Regeneration of Ligaments, Tendon and Capsule,Humana Press, July 2005. 
  23. J. W. Freeman, F. H. Silver, M. D. Woods, C. T. Laurencin, “The Role of Type I Collagen Molecular Structure in Tendon Elastic Energy Storage” Proceedings: Material Research Society Spring Symposium, Materials Research Society, 2005. 
  24. J. W. Freeman, F. H. Silver, “The Effects of Prestrain and Collagen Fibril Alignment on In Vitro Mineralization of Self-Assembled Collagen Fibers” Connect Tissue Res. 2005; 46(2):107-15. 
  25. H. H. Lu, J. A. Cooper, S. Manuel, J. W. Freeman, M. A. Attawia, F. K. Ko, C. T. Laurencin, “Anterior Cruciate Ligament Regeneration Using Braided Biodegradable Scaffolds: In Vitro Optimization Studies”, Biomaterials. 2005 Aug; 26(23):4805-16. 
  26. J. A. Cooper, H. H. Lu, F. K. Ko, J. W. Freeman, C. T. Laurencin, “Fiber-based tissue-engineered scaffold for ligament replacement: design considerations and in vitro evaluation”, Biomaterials. 2005 May; 26(13):1523-32. 
  27. J. W. Freeman, F. H. Silver, “Analysis Of Mineral Deposition In Turkey Tendons And Self-Assembled Collagen Fibers Using Mechanical Techniques” Connect Tissue Res. 2004; 45(3):131-41. 
  28. J. W. Freeman, F. H. Silver, “Elastic energy storage in unmineralized and mineralized extracellular matrices (ECMs): a comparison between molecular modeling and experimental measurements”, J Theor Biol. 2004 Aug 7; 229(3):371-81. 
  29. F. H. Silver, J. W. Freeman, and G. P. Seehra, “Collagen Self Assembly and. the Development of Tendon Mechanical Properties”, Journal of Biomechanics 2003 Oct; 36(10):1529-1553. 
  30. F. H. Silver, J. W. Freeman, I. Horvath, and G.Bradica, “The Role of Collagen in Energy Storage and Dissipation in ECM” Proceedings:Protein-based Nanotechnology Satellite Meeting, 47th Annual Meeting, Biophysical Society, 2003. 
  31. F.H. Silver, G. P, Seehra, and J. W. Freeman, and D. DeVore, “Viscoelastic Properties of Young and Old Human Dermis: A Proposed Molecular Mechanism for Elastic Energy Storage in Collagen and Elastin.” Journal of Applied Polymer Science 2002 Nov, 86(8):1978-85. 
  32. F. H. Silver, J. W. Freeman, I. Horvath, and W. J. Landis, “Molecular Basis for Elastic Energy Storage In Mineralized Tendon”, Biomacromolecules 2001 Sept; 2(1):750-756. 
  33. F.H. Silver, J. W. Freeman, and D. DeVore, “Viscoelastic Properties of Human Skin and Processed Dermis”, Skin Res Technol. 2001 Feb; 7(1):18-23. 

Conference Presentations

  1. J. W. Freeman (presenter), Mia D. Woods, Cato T. Laurencin, “Novel Braided Scaffolds For Ligament Tissue Engineering: Braid Effects On Toe Region And Ultimate
    Tensile Strength”, 52nd Annual Meeting of the Orthopaedic Research Society,
    March 19-22, Chicago, IL, 2006.
  2. J. W. Freeman (speaker), F. H. Silver, M. D. Woods, C. T. Laurencin, “The Role of Type I Collagen Molecular Structure in Tendon Elastic Energy Storage” Material Research Society Symposium,March 28 – April 1, San Francisco,
    CA, 2005.
  3. S. Lakshmi (presenter), Y. E. Greish, J. W. Freeman, J. D. Bender, P. W. Brown, H. R. Allcock, C. T. Laurencin, Polyphosphazene- hydroxyapatite scaffolds for bone tissue engineering, 7th World Biomaterials Conference of the Society of Biomaterials, May 17-21, Sydney, Australia, 2004 – Poster.
  4. J. W. Freeman (speaker) “The Effects Of Mineralization on the Viscoelastic Properties and Elastic Energy Storage in Collagen”, Department of Engineering Science and Mechanics Seminar Series, Virginia Polytechnic and State University, Blacksburg, VA, November 20, 2002.
  5. J. W. Freeman (speaker), F. H. Silver “A Molecular Model Of The Elastic Energy
    Storage In Collagen And The Effects Of Mineralization”, Gordon Conference, Colby-Sawyer College, New London, NH, August 11-16, 2002.
  6. J. W. Freeman (presenter), F. H. Silver “A Molecular Model Of The Elastic Energy
    Storage In Collagen And The Effects Of Mineralization”, Gordon Conference, Colby-Sawyer College, New London, NH, August 11-16, 2002 –
    Poster.
  7. J. W. Freeman (presenter), F. H. Silver “Elastic Energy Storage in Type I Collagen
    and The Role of Imino Acid Poor Regions of the Triple Helix”, Gordon Conference, Williams College, Williamstown, MA, July, 2001 – Poster.
  8. F. H. Silver (presenter), J. W. Freeman, and W. J. Landis, “Viscoelastic
    Properties of Mineralized Tendon”, Gordon Conference, New London, NH, August 2000 – Poster.