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Publications

Nakamura M*, Keller MA, Fefelova N, Zhai P, Liu T, Tian Y, Ikeda S, Del Re DP, Li H, Xie LH, Sadoshima J. Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice. Nat Commun. 2023 Sep 19;14(1):5805. doi: 10.1038/s41467-023-41595-x.

Nakamura M*. Gut Microbiome: An Effector of Dietary Nitrate That Inhibits Cardiometabolic Disease? Diabetes 2023;72:835-837. doi: 10.2337/dbi23-0008. PMID: 37339354

Keller MA, Huang CY, Ivessa A, Singh S, Romanienko PJ, Nakamura M*. Bcl-x short-isoform is essential for maintaining homeostasis of multiple tissues. iScience 2023;26:106409. doi: 10.1016/j.isci.2023.106409. eCollection 2023 Apr 21. PMID: 37035008

Heather LC, Hafstad AD, Halade GV, Harmancey R, Mellor KM, Mishra PK, Mulvihill EE, Nabben M, Nakamura M, Rider OJ, Ruiz M, Wende AR, Ussher JR. Guidelines on models of diabetic heart disease. Am J Physiol Heart Circ Physiol. 2022 Jul 1;323(1):H176-H200. doi: 10.1152/ajpheart.00058.2022. PMID: 35657616

Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J. Alternative Mitophagy Protects the Heart Against Obesity-Associated Cardiomyopathy. Circ Res. 2021;129(12):1105-1121. PMID: 34724805

Venkatesh S, Baljinnyam E, Tong M, Kashihara T, Yan L, Liu T, Li H, Xie LH, Nakamura M, Oka S, Suzuki CK, Fraidenraich D, Sadoshima J. Proteomic analysis of mitochondrial biogenesis in cardiomyocytes differentiated from human induced pluripotent stem cells. Am J Physiol Regul Integr Comp Physiol. 2021 Apr 1;320(4):R547-R562. doi: 10.1152/ajpregu.00207.2020. PMID: 33112656

Nakamura M, Odanovic N, Nakada Y, Dohi S, Zhai P, Ivessa A, Yang Z, Abdellatif M, Sadoshima J. Dietary carbohydrates restriction inhibits the development of cardiac hypertrophy and heart failure. Cardiovasc Res. 2021;117(11):2365-2376. PMID: 33070172

Ikeda S, Mukai R, Mizushima W, Zhai P, Oka SI, Nakamura M, Del Re DP, Sciarretta S, Hsu CP, Shimokawa H, Sadoshima J. Yes-Associated Protein (YAP) Facilitates Pressure Overload-Induced Dysfunction in the Diabetic Heart. JACC Basic Transl Sci 2019;4:611-622. PMID: 31768477

Nakamura M, Sadoshima J. Ketone body can be a fuel substrate for failing heart. Cardiovasc Res 2019;115:1567-1569. PMID: 30989167

Nakamura M, Sadoshima J. Cardiomyopathy in obesity, insulin resistance and diabetes. J Physiol. 2020 Jul;598(14):2977-2993. doi: 10.1113/JP276747. PMID: 30869158

Tong M, Saito T, Zhai P, Oka SI, Mizushima W, Nakamura M, Ikeda S, Shirakabe A, Sadoshima J. Mitophagy Is Essential for Maintaining Cardiac Function During High Fat Diet-Induced Diabetic Cardiomyopathy. Circ Res 2019;124:1360-1371. PMID: 30786833

Nakamura M, Liu T, Husain S, Zhai P, Warren JS, Hsu CP, Matsuda T, Phiel CJ, Cox JE, Tian B, Li H, Sadoshima J. Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy. Cell Metab 2019; 29:1119-1134. PMID: 30745182

Tomiyama H, Ohkuma T, Ninomiya T, Mastumoto C, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A; collaborative group for J-BAVELs (Japan Brachial-Ankle pulse wave VELocity Individual Participant Data Meta-Analysis of Prospective Studies). Steno-Stiffness Approach for Cardiovascular Disease Risk Assessment in Primary Prevention. Hypertension 2019;73:508-513. PMID: 30636553

Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, Del Re DP, Farrance I, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS, Sadoshima J. Hippo Deficiency Leads to Cardiac Dysfunction Accompanied by Cardiomyocyte Dedifferentiation During Pressure Overload. Circ Res 2019;124:292-305. PMID: 30582455

Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Aboyans V, Yamashina A; collaborative group for the Japan Brachial-Ankle pulse wave VELocity individual participant data meta-analysis of prospective studies to examine the significance of the Ankle-Brachial Index (J-VABEL-ABI). Ankle-brachial index measured by oscillometry is predictive for cardiovascular disease and premature death in the Japanese population: An individual participant data meta-analysis. Atherosclerosis. 2018;275:141-148. PMID: 29902702

Nakamura M, Sadoshima J. Mechanisms of physiological and pathological cardiac hypertrophy. Nat Rev Cardiol. 2018;15:387-407. PMID: 29674714

Tomiyama H, Ohkuma T, Ninomiya T, Mastumoto C, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A; collaborative group for J-VABEL-IAD (Japan Brachial-Ankle Pulse Wave Velocity Individual Participant Data Meta-Analysis of Prospective Studies to Examine the Significance of Inter-Arm Blood Pressure Difference). Simultaneously Measured Interarm Blood Pressure Difference and Stroke: An Individual Participants Data Meta-Analysis. Hypertension. 2018 Jun;71(6):1030-1038. PMID: 29632099

Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A; Collaborative Group for J-BAVEL (Japan Brachial-Ankle Pulse Wave Velocity Individual Participant Data Meta-Analysis of Prospective Studies). Proposed Cutoff Value of Brachial-Ankle Pulse Wave Velocity for the Management of Hypertension. Circ J 2017 Sep 25;81(10):1540-1542. PMID: 28835589

Ohkuma T, Ninomiya T, Tomiyama H, Kario K, Hoshide S, Kita Y, Inoguchi T, Maeda Y, Kohara K, Tabara Y, Nakamura M, Ohkubo T, Watada H, Munakata M, Ohishi M, Ito N, Nakamura M, Shoji T, Vlachopoulos C, Yamashina A; Collaborative Group for J-BAVEL (Japan Brachial-Ankle Pulse Wave Velocity Individual Participant Data Meta-Analysis of Prospective Studies). Brachial-Ankle Pulse Wave Velocity and the Risk Prediction of Cardiovascular Disease: An Individual Participant Data Meta-Analysis. Hypertension 2017;69:1045-1052. PMID: 28438905

Nakamura M, Zhai P, Del Re DP, Maejima Y, Sadoshima J. Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI Insight 2016;1. pii: e86217. PMID: 27218122

Nakamura M, Sadoshima J. Heart over mind: metabolic control of white adipose tissue and liver. EMBO Mol Med 2014; 6:1521-4. PMID: 25471454

Nakamura M, Bhatnagar A, Sadoshima J. Overview of pyridine nucleotides review series. Circ Res 2012; 111:604-10. PMID: 22904040

Yajima T, Murofushi Y, Zhou H, Park S, Housman J, Zhong ZH, Nakamura M, Machida M, Hwang KK, Gu Y, Dalton ND, Yajima T, Yasukawa H, Peterson KL, Knowlton KU. Absence of SOCS3 in the cardiomyocyte increases mortality in a gp130-dependent manner accompanied by contractile dysfunction and ventricular arrhythmias. Circulation 2011; 124:2690-701. PMID: 22082679

Nakamura M, Yamashita T, Yajima J, Oikawa Y, Ogasawara K, Sagara K, Koike A, Kirigaya H, Nagashima K, Otsuka T, Uejima T, Funada R, Matsuno S, Suzuki S, Sawada H, Aizawa T; the Shinken Database Study Group. Impact of early statin initiation on secondary prevention in Japanese patients with coronary artery disease. J Cardiol 2011; 57:172-180.

Oikawa Y, Yajima J, Costa MA, Matsuno S, Akabane M, Funada R, Inaba T, Nakagawa Y, Nakamura M, Nagashima K, Kirigaya H, Ogasawara K, Sawada H, Aizawa T. Intravascular ultrasound, angioscopic and histopathological characterisation of heterogeneous patterns of restenosis after sirolimus-eluting stent implantation: insights into potential “thromborestenosis” phenomenon. EuroIntervention 2010; 6:380-7.

Nakamura M, Yamashita T, Yajima J, Oikawa Y, Sagara K, Koike A, Kirigaya H, Nagashima K, Sawada H, Aizawa T; Shinken Database Study Group. Brachial-ankle pulse wave velocity as a risk stratification index for the short-term prognosis of type 2 diabetic patients with coronary artery disease. Hypertens Res 2010; 33:1018-24.

Nakamura M, Yamashita T, Yajima J, Oikawa Y, Ogasawara K, Sagara K, Kirigaya H, Koike K, Nagashima K, Otsuka T, Uejima T, Suzuki S, Sawada H, Aizawa T. “Clinical Outcome after Acute Coronary Syndrome in Japanese Patients: An Observational Cohort Study” J Cardiol 2010; 55:69-76.

Nakamura M, Yamashita T, Yajima J, Oikawa Y, Ogasawara K, Kirigaya H, Sagara K, Koike A, Sawada H, Aizawa T. “Impact of Reduced Renal Function on Prognosis in Japanese Patients with Coronary Artery Disease: A Prospective Cohort of Shinken Database 2007” Hypertens Res 2009; 32:920-6.

Nakagawa Y, Oikawa Y, Yajima J, Funada R, Matsuno S, Inaba T, Nakamura M, Ogasawara K, Kirigaya H, Nagashima K, Sawada H, Aizawa T. How should we treat for ischemic heart disease in dialysis patients: PCI or CABG? Shinzou 2009; 41:304-7. (Japanese)

Nakamura M, Yamashita T, Yajima J, Oikawa Y, Ogasawara K, Kirigaya H, Nagashima K, Sawada H, Aizawa T. “Long-Term Safety and Efficacy of Sirolimus-Eluting Stents in Japanese Patients: a Single Center Cohort Study” J Invasive Cardiol 2009; 21:526-31.

Nakagawa Y, Yajima J, Oikawa J, Ogasawara K, Kirigaya H, Nagashima K, Funada R, Matsuno S, Inaba T, Nakamura M, Sawada H, Aizawa T. Clinical outcomes after percutaneous peripheral intervention for chronic total occlusion of superficial femoral arteries: Comparison between self-expandable nitinol stent and stainless steel stent. J Cardiol 2009; 53: 417-21.

Nakamura M, Yajima J, Oikawa Y, Ogasawara K, Uejima T, Abe K, Aizawa T. Vascular Ehlers-Danlos Syndrome-All Three Coronary Artery Spontaneous Dissections. J Cardiol 2009; 53:458-62.

Funada R, Oikawa Y, Yajima J, Kirigaya H, Nagashima K, Ogasawara K, Matsuno S, Inaba T, Nakagawa Y, Nakamura M, Kurabayashi M, Aizawa T. The potential of RF backscattered IVUS data and multidetector-row computed tomography images for tissue characterization of human coronary atherosclerotic plaques. Int J Cardiovasc Imaging 2009; 25:471-8.

Oikawa Y, Yajima J, Akabane M, Funada R, Matsuno S, Inaba T, Nakagawa Y, Nakamura M, Nagashima K, Kirigaya H, Ogasawara K, Aizawa T. The Frequency and Follow-up Results of Coronary Perforation. Jpn J Interv Cardiol 2008; 23:110-3.

Oikawa Y, Yajima J, Angiolillo DJ, Akabane M, Funada R, Matsuno S, Inaba T, Nakagawa Y, Nakamura M, Sawada H, Aizawa T. Short- or long-term outcomes of coronary artery aneurysms occurring after directional coronary atherectomy. J Invasive Cardiol. 2008; 20:159-60.