Lee, Deidre: Finite Element Modeling of Electroporation Phenomenon Using Microfluidics Devices

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Title: Finite Element Modeling of Electroporation Phenomenon Using Microfluidics Devices

Name: Deidre Lee

Home Institute: University of the Virgin Islands

Programs: RISE program, REU – Cellular Bioengineering

Other contributors: Jeffery D. Zahn, Christopher Kidchob, Upasana Ghosh

Abstract: Electroporation is a technique in which an electric pulse is applied to cells which generates a membrane potential difference, and induces temporal pores in the cell membrane; allowing access for molecular delivery into the intracellular space. However, the task of obtaining efficient delivery without compromising cell viability is crucial when using this technique. A microfluidic platform is a unique way to electroporate flowing cells in an automated and controlled manner while increasing cell viability. Computational models are crucial in the design process, as they can identify a microfluidic and electrical design for optimal results. My role in this ongoing project is to model a microfluidic platform that performs electroporation on blood cell types using COMSOL Multiphysics.

Biography: Not available