Associate Professor | Rutgers RWJMS
Dr. Mi-Hyeon Jang has had a longstanding interest in the field of regenerative medicine. The focus of research in Dr. Jang’s laboratory is to understand the underlying neurobiological mechanisms that promote regenerative processes of adult neurogenesis, oligodendrogenesis, and myelination. We hope to discover novel regenerative strategies for improving learning and memory function in brain aging, as well as neurological and neurodegenerative disorders. Building on my earlier work in brain aging, Dr. Jang’s laboratory pursues a new direction focused on chemotherapy-induced cognitive impairment (also known as chemobrain) which resembles the brain aging process. Given that multiple molecular pathways contribute to the pathogenesis of chemobrain, we aim to uncover the molecular contributors driving chemobrain to direct development of rationally designed synergistic “disease-modifying therapeutic strategies” to ameliorate chemobrain, thus ultimately improving quality of life for cancer survivors. Dr. Jang is a core member of Rutgers Brain Health Institute (BHI) and an active full member of the Cancer Pharmacology Program at Cancer Institute of New Jersey (CINJ).
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Education:
Graduate:
M.S. Kyung Hee University, South Korea (Physiology)
Doctorate:
M.S. Kyung Hee University, South Korea (Physiology), 2005
Fellowship:
Post-doctoral fellow: Johns Hopkins University, Institute for Cell Engineering, Baltimore, MD, USA, 2012
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Awards:
- Cancer Survivorship Research Center’s Pilot Award from Rutgers CINJ (2022)
- Discovery Research Award from Regenerative Medicine Minnesota (2019)
- Eagles 5th District Cancer Telethon Funds for Cancer Research (2019)
- Research Award from Regenerative Medicine Minnesota (2017)
- Pilot Research Award from SPORE at Mayo Clinic Cancer Center (2017)
- Career Development Award in Regenerative Medicine and Science, Mayo Clinic Center for Regenerative Medicine (2014)
- Accelerated Regenerative Medicine Award, Mayo Clinic Center for Regenerative Medicine (2013)
- Research Grant, Whitehall Foundation (2013)
- The Janet Rosenberg Trubatch Career Development Award for Society for Neuroscience (SfN) (2013)
- Fraternal Order of Eagles Award, Mayo Clinic Cancer Center (2012)
- Travel Award for American College of Neuropsychopharmacology (2011)
- NIH Pathway to Independence Award (K99/R00) (2010)
- The 4th Julius Axelrod Travel Award for Society for Neuroscience (SfN) (2010)
- NARSAD Young Investigator Award (2010)
- Best Poster Award, ICE Symposium 2008, Johns Hopkins University (2008)
- Kyung Hee University Medical School Award for the Best PhD Thesis (2005)
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Research Interests:
- Investigation of regenerative neurobiology (neurogenesis, oligodendrogenesis, myelination) in the contexts of learning, memory and emotional regulation.
- Application of iPSCs to study disease mechanism and drug screen.
- Investigation of pathophysiological mechanisms of chemobrain (chemotherapy-induced cognitive dysfunction).
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Publications:
Blockade of the Adenosine A2A receptor prevents against cisplatin-induced cognitive impairment.
Oliveros A*, Yoo KH*, Rashid MA*, Corujo-Ramirez A, Liu Y, Hur B, Sung J, Hawse JR, Choi DS, Boison D, and Jang MH., Proc Nat Acad Sci,. Jul 12; 119(28):e2206415119. doi: 10.1073/pnas.2206415119. Epub 2022 Jul 7. PubMed PMID: 35867768, 2022
Nicotinamide mononucleotide prevents chemotherapy-induced cognitive impairments.
Yoo KH*, Tang JJ*, Rashid MA*, Cho CH, Corujo-Ramirez A, Choi JH, Bae MG, Brogren D, Hawse JR, Hou X, Weroha SJ, Oliveros A, Kirkeby LA, Baur JA, Jang MH., Cancer Research, 3290.2020. doi: 10.1158/0008-5472.CAN-20-3290. PubMed PMID: 33771896, 2021
Early stem Cell aging in the mature brain.
Ibrayeva A, Bay M, Pu E, Jörg D, Peng L, Jun H, Zhang N, Aaron D, Lin C, Resler G, Jang MH., Simons BD, Bonaguidi MA., Cell Stem Cell, 28(5):955-966.e7. doi: 10.1016/j.stem.2021.03.018. PubMed PMID: 33848469, 2021
sFRP3 inhibition improves age-related cellular changes in BubR1 progeroid mice.
Cho CH*, Yoo KH*, Oliveros A, Paulson S, Hussaini SMQ, van Deursen JM, Jang MH., Aging Cell., Jan 4:e12899. doi: 10.1111/acel.12899. [Epub ahead of print] PubMed PMID: 30609266, 2019
DISC1 in Astrocytes Influences Adult Neurogenesis and Hippocampus-Dependent Behaviors in Mice.
Terrillion CE*, Abazyan B*, Yang Z*, Crawford J, Shevelkin AV, Jouroukhin Y, Yoo KH, Cho CH, Roychaudhuri R, Snyder SH, Jang MH., Pletnikov MV,.
Neuropsychopharmacology, Oct;42(11):2242-2251. doi: 10.1038/npp.2017.129. Epub 2017 Jun 20. PubMed PMID: 28631721; PubMed Central PMCID: PMC5603806, 2017
Age-related decline in BubR1 impairs adult hippocampal neurogenesis.
Yang Z*, Jun H*, Choi CI, Yoo KH, Cho CH, Hussaini SMQ, Simmons AJ, Kim S, van Deursen JM, Baker DJ, Jang MH., Aging Cell., Jun;16(3):598-601. doi: 10.1111/acel.12594. Epub 2017 Apr 6. PubMed PMID: 28383136; PubMed Central PMCID: PMC5418205, 2017
The progeroid gene BubR1 regulates axon myelination and motor function.
Choi CI, Yoo KH, Hussaini SM, Jeon BT, Welby J, Gan H, Scarisbrick IA, Zhang Z, Baker DJ, van Deursen JM, Rodriguez M, Jang MH., Aging (Albany NY), Sep 12;8(11):2667-2688. doi: 10.18632/aging.101032. PubMed PMID: 27922816; PubMed Central PMCID: PMC5191862, 2016
Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis.
Jang MH., Bonaguidi MA*, Kitabatake Y*, Sun J*, Song J, Kang E, Jun H, Zhong C, Su Y, Guo JU, Wang MX, Sailor KA, Kim JY, Gao Y, Christian KM, Ming G, Song H#., Cell Stem Cell., 12 (2) 215-223 (PMID: 23395446), 2013
Secreted Frizzled-related Protein 3 (sFRP3) regulates antidepressant responses in mice and humans.
Jang MH., Kitabatake Y*, Kang E, Jun H, Pletnikov MV, Christian KM, Hen R, Binder EB, Song H, Ming GL., Psychiatry, 18 (9) 957-958 (PMID: 23207650), 2013
Neuronal activity-induced Gadd45b promotes epigenetic DNA demethylation and adult neurogenesis.
Ma DK*, Jang MH., Guo JU, Kitabatake Y. Chang ML, Pow-anpongkul N, Flavell RA, Lu B, Ming GL, Song H., S Science; 323 (5917): 1074-1077, 2009
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Location:
Rutgers, The State University of New Jersey
Staged Research Building,
661 Hoes Lane West, Room 144 & 145,
Piscataway, NJ 08854