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Schindler lab
Our lab studies meiosis, the process that controls female gamete (eggs) formation, with the overall goal of understanding why this process is inherently error prone. In all sexually reproducing animals, mistakes in meiosis can result in the formation of eggs with the wrong number of chromosomes (aneuploidy) and are highly linked to infertility, miscarriage and developmental disorders such as Down Syndrome. A surprising number of eggs (an estimated 5-20%) from reproductively young, healthy women are aneuploid and this incidence increases with maternal age. Little is known, however, about how meiosis in females is regulated.