Publications (2019-2024) – Schindler Lab

1. Biswas L, Tyc KM, Aboelenain M, Sun S, Dundovic I, Vukusic K, Liu J, Guo V, Xu M, Scott RS, Tao X, Tolic IM, Xing J, Schindler K. (2024). Maternal genetic variants in kinesin motor domains prematurely increase egg aneuploidy. PNAS. 121(45):e2414963121.

2. Blengini CS and Schindler K. (2024). Genetic interaction mapping of Aurora protein kinases in mouse oocytes. Frontiers in Cell and Developmental Biology: Molecular and Cellular Reproduction. 12:1455280.

3. Blengini CS, Vaskovicova M, Schier J, Drutovic D, Schindler K. (2024). Spatio-temporal requirements of Aurora kinase A in mouse oocyte meiotic spindle building. iScience 27(8):110451.

4. Kunitomi C, Romero M, Daldello EM, Schindler K, Conti M. (2024). Multiple intersecting pathways are involved in CPEB1 phosphorylation and regulation of translation during mouse oocyte meiosis. Development. 151(11):dev202712.

5. Ly J, Blengini CS, Cady SL, Schindler K, Cheeseman IM. (2024). A conserved germline-specific Dsn1 alternative splice isoform supports oocyte and embryo development. Current Biology. 34(18):4307-4317.e6.

6. Sun S, Defosse T, Boyd A, Sop J, Verderose F, Surray D, Aziz M, Howland M, Wu S, Changela N, Jang J, Schindler K, Xing J, McKim K. (2024). Whole Transcriptome and Functional Analyses Identify Novel Genes Involved in Meiosis and Fertility using Drosophila melanogaster. Scientific Reports. 14(1): 3602.

7. Mendola RJ, Biswas L, Schindler K, Walmsley RH, Russell H, Angle M, Garrisi GJ. (2024). Influx of Zwitterionic Buffer after Intracytoplasmic Sperm Injection (ICSI) Membrane Piercing Alters the Transcriptome of Human Oocytes. Journal of Assisted Reproduction and Genetics. 41: 1341-1356.

8. Sun S, Aboelenain M, Ariad D, Haywood ME, Wageman CR, Duke M, Bag A, Viotti M, Katz-Jaffe M, McCoy RC, Schindler K, Xing J. (2023). Identifying risk genes for embryo aneuploidy using ultra-low coverage whole-genome sequencing from preimplantation genetic testing. American Journal of Human Genetics. 110(12): 2092-2102.

9. Jung GI, London-Vasquez D, Park SJ, Skop AR, Balboula AZ, Schindler K. (2023). A meiotic midbody structure is required for developmental competence of mouse oocytes. Nature Communications. 14(1):7419.

10. Kirsanov O, Johnson TA, Niedenberger BA, Malachowski TN, Hale BJ, Chen Q, Lackford B, Wang J, Singh A, Schindler K, Hermann BP, Hu GP, Geyer CB. (2023). Retinoic acid is dispensable for meiotic initiation but required for spermiogenesis in the mammalian testis. Development. 150(14):dev201638.

11. Briley SM, Ahmed AA, Steenwinkel TE, Jiang P, Hartig SM, Schindler K, Pangas SA. (2023). Global SUMOylation in mouse oocytes maintains oocyte identity and regulates chomatin remodeling and transcriptional silencing at the end of folliculogenesis. Development. 150(17):dev201535.

12. Cairo G, Greiwe C, Jung GI, Blengini CS, Schindler K, Lacefield S. (2023). Distinct Aurora B pools have different contributions to meiotic and mitotic chromosome segregation. Journal of Cell Biology. 34(5): ar43.

13. Blengini CS, Jung GI, Aboelenain M, Schindler K. (2022). A field guide to Aurora kinase inhibitors: an oocyte perspective. Reproduction. 164(4): V5-7.

14. Aboelenain M, Schindler K, Blengini CS. (2022). Methods to evaluate integrity of the spindle assembly checkpoint in mouse oocytes. Journal of Visualized Experiments. 187.

15. Sun S, Miller M, Wang Y, Tyc KM, Cao X, Scott RT, Tao X, Bromberg Y, Schindler K and Xing J. (2022). Predicting embryonic aneuploidy rate in IVF patients using whole-exome sequencing. Hum Genet. doi: 10.1007/s00439-022-02450-z. Online ahead of print.

16. Kratka C, Drutovic D, Blengini CS, Schindler K. (2022). Using ZINC08918027 inhibitor to determine Aurora kinase-chromosomal passenger complex isoforms in mouse oocytes. BMC Res Notes. 15(1): 96.

17. Blengini CS and Schindler K. (2022). Acentriolar spindle assembly in mammalian female meiosis and the consequences of its perturbations on human reproduction. Biology of Reproduction. 106(2): 253-63.

18. Aboelenain M and Schindler K. (2021). Aurora kinase B negatively regulates Aurora kinase A to control maternal mRNA translation in mouse oocytes. Development. 148(21): dev.199560.

19. Blengini CS, Nguyen AL, Aboelenain M, Schindler K. (2021). Age-dependent integrity of the meiotic spindle assembly checkpoint in females requires Aurora kinase B. Aging Cell. 20(11):e13489.

20. Vazquez BN, Quartuccio SM, Schindler K. (2021). An analog-sensitive allele of Aurora kinase B is lethal in mouse. microPublication. 2021:10.17912/micropub.biology.000491.

21. Singh P, Fragoza R, Blengini CS, Tran TN, Pannafino G, Al-Sweel N, Schimenti KJ, Schindler K, Alani EA, Yu H, Schimenti JC. (2021) MLH1/3 variants causing aneuploidy, pregnancy loss, and premature reproductive aging. Nature Communications. 12(1):5005.

22. Blengini CS, Ibrahimian P, Vaskovicova M, Drutovic D, Solc P, Schindler K. (2021). Aurora kinase A is essential for meiosis in mouse oocytes. PLoS Genetics. 17(4):e1009327.

23. Wartosch L, Schindler K, Schuh M, Gruhn JR, Hoffmann ER, McCoy RC, Xing J. (2021). Origins and Mechanisms Leading to Aneuploidy in Human Eggs. Prenatal Diagnosis. 41(5): 620-30.

24. Biswas L, Tyc K, El Yakoubi W, Morgan K, Xing J, Schindler K. (2021). Meiosis interrupted: the genetics of female infertility via meiotic failure. Reproduction. 161(2): R13-R35.

25. Tyc KM, Wong A, Scott RT, Tao X, Schindler K, Xing J. (2021). Analysis of DNA variants in miRNAs and miRNA 3’UTR binding sites in female infertility patients. Laboratory Investigation. 101(4): 503-12.

26. Wellard SR, Schindler K, Jordan JW. (2020). Aurora B and C kinases regulate prophase exit and chromosome segregation during spermatogenesis. Journal of Cell Science. 133(23): jcs248831.

27. Duncan FE, Schindler K, Schultz RM, Blengini CS, Stricker SA, Wessel GM, Williams CJ. (2020). Unscrambling the oocyte and the egg: clarifying terminology of the female gamete in mammals. Molecular Human Reproduction. 26(11): 797-800.

28. Vazquez BN, Vaquero A, Schindler K. (2020). Sirtuins in female meiosis and in reproductive longevity. Molecular Reproduction and Development. 87(12): 1175-87.

29. Tyc KM, El Yakoubi W, Bag A, Landis J, Zhan Y, Treff NR, Scott RT, Tao X, Schindler K, Xing J. (2020). Whole exome sequencing implicates CEP120 in human aneuploid conception risk. Human Reproduction. 35(9): 2134-48.

30. Balboula AZ, Schindler K, Kotani T, Takahasi M. (2020). Vitrification-Induced Activation of Lysosomal Cathepsin B Perturbs Spindle Assembly Checkpoint Function in Mouse Oocytes. Molecular Human Reproduction. 26(9): 689-701.

31. Tyc KM, McCoy RC, Schindler K, Xing J. Mathematical modeling of aneuploid conception risk. (2020). Proceedings of the National Academy of Sciences USA. 117(19): 10455-10464.

32. Beard S, Pritchard N, Binder N, Schindler K, De Alwis N; Kaitu’u-Lino T, Tong S, Hannan N. (2020). Aurora Kinase mRNA expression is reduced with increasing gestational age and in severe early onset fetal growth restriction. Placenta. 95: 53-61.

33. Vazquez BN, Blengini CS, Hernandez Y, Serrano L, and Schindler K. (2019). SIRT7 promotes chromosome synapsis during prophase I of female meiosis. 128: 369-383.