Research
We are working on multiple exciting, basic, translational, and impactful research projects advancing women’s reproductive health, including biology, medicine, drug development, and toxicology:
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Environmental exposures and women’s reproductive health and fertility
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Female reproductive organoids and organ-on-chip
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Cancer therapy-induced female reproductive toxicity, fertility, and hormone preservation
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Impact of hormone homeostasis in women’s pharmacology and toxicology
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Non-hormonal contraceptive discovery targeting ovulation
Our research is or has been generously supported by NIH (NIEHS, NICHD), DOD, NSF, Gates Foundation, HESI, Rutgers Office of Research, and EOHSI. Our current projects include:
NIH/ORWH Woodruff (PI), Xiao (MPI), Zhang, Zhu (MPI) 09/15/2026-09/14/2029
Office of Research on Women’s Health (ORWH)
Computational Modeling of Female Hormone Homeostasis and Drug Responses
NIH R01ES037796 Gaskins (PI), Xiao (MPI), Demokritou (MPI) 09/25/2025 – 07/31/2030
A transdisciplinary approach to evaluate the effects of wildfire smoke on fertility
NIH R01ES035766 Xiao (PI), Zhang (MPI) 12/13/2024 – 10/31/2029
Ovarian disrupting effects of per- and polyfluoroalkyl substances (PFAS) on gonadotropin-dependent folliculogenesis and ovulation
NIH R01HD115810 Xiao (PI), Kim (MPI) 08/16/2024 – 05/31/2029
Oogenic JNK in gonadotoxic chemotherapy-induced primary ovarian insufficiency
NIH R01HD114750 Ye (PI), Xiao (MPI), Segars (MPI) 04/01/2024 – 03/30/2029
Mechanisms of uterine fluid absorption during early pregnancy
NIH UG3TR005857 German (PI), Xiao (Consultant) 08/15/2025 – 07/31/2028
An Organ-on-Chip Approach to Evaluation of Reproductive Health, Aging, and Disease in Women
NIH R01ES032144 Xiao (PI) 09/20/2021 – 05/31/2026
An ovary-on-a-chip to identify ovarian toxicity
DOD HT9425-23-1-0809 Xiao (PI) 10/01/2023 – 09/30/2026
Ovarian disrupting effects and mechanisms of per- and polyfluoroalkyl substances