Publications
2025
Han X, Shen J, Yan J, Tacke R, Dai W, Mao Q, Daguplo HQ, Liu S, Islam A, Liu T, Koch M, Lin RZ, Li H, Anthony T, Xie P, Zhang L, Gao S, Simon MC, Chen X, Yang J, Su X, and Zong WX*. Defective nitrogenous waste clearance culminates hepatocellular carcinoma. Sci Adv. 2025 (in press)
Meng X, Wang W, Sheshadri N, Zhang T, Han X, Sun Y, Xiao M, Feng Y, Gao S, Chen J, Xie S, Wang Y, Yang Y, Zhao Y, Yin Y, Zong WX* (co-corresponding), and Gao S*. SERPINB3 enhances NPM1 sumoylation via inhibiting SENP3’s activity and promotes lung tumorigenesis. Cell Death Dis. 2025. (in press)
Jung J, Zhu S, Lalani A, Shakarchi J, Matracz B, Wu GG, Zong WX, Zhao L, Xie P. Commensal bacteria drive B-cell lymphomagenesis in the setting of innate immunodeficiency. Blood Cancer Discov. 2025 Jul 3. PMID: 40608826. doi: 10.1158/2643-3230.BCD-24-0279.
Yan Y, Wang N, Xing B, Yang M, Shang J, Bao Y, Xiao L, Zhang N, Ren Y, Liu C, Chen Y, Han H, Pan Y, Lv L, Zong WX, Ji H, Zhan C, Wang Z, Chen H, Wang Y. Splicing shift of RAC1 accelerates tumorigenesis and defines a potent therapeutic target in lung cancer. Adv Sci. 2025 Jun 23:e03322. PMID: 40548642. doi: 10.1002/advs.202503322.
Han HV, Efem R, Rosati B, Lu K, Maimouni S, Jiang YP, Montoya V, Van Der Velden A, Zong WX, Lin RZ. Propionyl-CoA carboxylase subunit B regulates anti-tumor T cells in a pancreatic cancer mouse model. eLife. 2025 Mar 11;13:RP96925. PMID: 40067762. doi:10.7554/eLife.96925.2.
Li P, Dong X, Xu L, Hu X, Meng X, Yang P, Zhang X, Zong WX, Gao S, Zhuang S, Xin H.
TRIM21 knockout alleviates renal fibrosis by promoting autophagic degradation of mature TGF-β1. Biochem Pharmacol. 2025 Apr; 234:116822. PMID: 39983846. doi: 10.1016/j.bcp.2025.116822. Epub 2025 Feb 19.
2024
Yang P#, Gao S# (co-first author), Shen J, Liu T, Lu K, Han X, Wang J, Ni HM, Ding WX, Li H, Pan JA, Peng K* (co-corresponding), and Zong WX*. TRIM21-mediated ubiquitylation of SQSTM1/p62 abolishes its Ser403 phosphorylation and enhances palmitic acid cytotoxicity. Autophagy. 2024 September 10: 1-13. PMID: 39172027. DOI: 10.1080/15548627.2024.2394308.
Han X#, Wang D# (co-first author), Yang L, Wang N, Shen J, Wang J, Zhang L, Chen L, Gao S, Zong WX* (co-corresponding), Wang Y*. 2024. Activation of polyamine catabolism promotes glutamine metabolism and creates a targetable vulnerability in lung cancer. PNAS. 2024 Mar 26;121(13):e2319429121. PMID: 38513095. doi: 10.1073/pnas.2319429121.
Yang X, Wang J, Chang CY, Zhou F, Liu J, Xu H, Ibrahim M, Gomez M, Zong WX, Wondisford FE, Su X, White E, Feng Z, Hu W. 2023. Leukemia inhibitory factor suppresses hepatic de novo lipogenesis and induces cachexia. Nat Communi. 2024 Jan 20;15(1):627. PMID: 38245529. doi: 10.1038/s41467-024-44924-w.
Hou K, Liu L, Fang ZH, Zong WX, Sun D, Guo Z, Cao L. The role of ferroptosis in cardio-oncology. Arch Toxicol. 2024 Jan 5. PMID: 38182913. doi: 10.1007/s00204-023-03665-3.
2023
Xu N, Ren Y, Bao Y, Shen X, Kang J, Wang N, Wang Z, Han X, Li Z, Zuo J, Wei GH, Wang Z, Zong WX, Liu W, Xie G, Wang Y. PUF60 promotes cell cycle and lung cancer progression by regulating alternative splicing of CDC25C. Cell Rep. 2023 Sep 7;42(9):113041. PMID: 37682709. DOI: 10.1016/j.celrep.2023.113041.
Winz C,Zong WX, Suh N. Endocrine-disrupting compounds and metabolomic reprogramming in breast cancer. J Biochem Mol Toxicol. 2023 Aug 20;e23506. PMID: 37598318. DOI: 10.1002/jbt.23506.
Chao X, Wang S, Ma X, Zhang C, Qian H, Williams SN, Sun Z, Peng Z, Liu W, Li F, Sheshadri N, Zong WX, Ni HM, Ding WX. Persistent mTORC1 activation due to loss of liver tuberous sclerosis complex 1 promotes liver injury in alcoholic hepatitis. Hepatology. 2023 Apr 3. PMID: 36999531. doi: 10.1097/HEP.0000000000000373.
Sun X, Huang N, Li P, Dong X, Yang J, Zhang X, Zong WX, Gao S, Xin H. TRIM21 ubiquitylates GPX4 and promotes ferroptosis to aggravate ischemia/reperfusion-induced acute kidney injury. Life Sci. 2023 Mar 21;321:121608. PMID: 36958437. doi: 10.1016/j.lfs.2023.121608.
Bao Y, Zhang S, Zhang X, Pan Y, Yan Y, Wang N, Ren Y, Zuo J, Zong WX, Wang Z, Wang Y. RBM10 loss promotes EGFR-driven lung cancer and confers sensitivity to spliceosome inhibition. Cancer Res. 2023 Feb 28:CAN-22-1549. PMID: 36853175. doi: 10.1158/0008-5472.CAN-22-1549.
Dai W and Zong WX*. Glutamine synthetase, a tumor suppressor in hepatocellular carcinoma? J Mol Cell Biol. 2023 Feb 3:mjad007. PMID: 36737414. PMID: 36737414. DOI: 10.1093/jmcb/mjad007.
Liu J, Zhang C, Xu D, Zhang T, Chang CY, Wang J, Liu J, Zhang L, Haffty BG, Zong WX, Hu W, Feng Z. The ubiquitin ligase TRIM21 regulates mutant p53 accumulation and gain-of-function in cancer. J Clin Invest. 2023 Feb 7:e164354 (2023). PMID: 36749630. DOI: 10.1172/JCI164354.
2022
Dai W#, Shen J# (co-first author), Yan J, Bott AJ, Maimouni S, Daguplo HQ, Wang Y, Khayati K, Guo JY, Zhang L, Wang Y, Gao S, Valvezan A, Ding WX, Chen X, Su X, and Zong WX*. Glutamine synthetase limits b-catenin-mutated liver cancer growth by maintaining nitrogen homeostasis and suppressing mTORC1. J Clin Invest. 2022 Oct 18:e161408. PMID: 36256480. DOI: 10.1172/JCI161408.
Huang Y. Du S. Liu, Huang W, Liu W, Zhang M, Li N, Wang R, Wu J, Chen W, Jiang M, Zhou T, Cao J, Yang J, Huang L, Gu A, Niu J, Cao Y, Zong WX, Wang X, Liu J, Qian K, and Wang H. Diagnosis and prognosis of breast cancer by high-performance serum metabolic fingerprints. PNAS 119 (12) e2122245119 (2022). PMID: 35302894. DOI: 10.1073/pnas.2122245119.
2021
Shen N, Korm S, Karantanos T, Li D, Zhang X, Ritou E, Xu H, Lam A, English J, Zong WX, Liu CT, Shirihai O, Feng H. DLST-dependence dictates metabolic heterogeneity in TCA-cycle usage among triple-negative breast cancer. Communi Biol. 2021 Nov 16;4(1):1289. PMID: 34785772. DOI: 10.1038/s42003-021-02805-8.
Liu Y, Gokhale S, Jung J, Zhu S, Luo C, Saha D, Guo JY, Zhang H, Kyin S, Zong WX, White E, Xie P. Mitochondrial Fission Factor Is a Novel Interacting Protein of the Critical B Cell Survival Regulator TRAF3 in B Lymphocytes. Front Immunol 2021 Oct 20;12:670338. PMID: 34745083. DOI: 10.3389/fimmu.2021.670338.
Chao X, Wang S, Fulte S, Ma X, Ahamed F, Cui W, Liu Z, Rülicke T, Zatloukal K, Zong WX, Liu W, Ni HM, Ding WX. Hepatocytic p62 suppresses ductular reaction and tumorigenesis in mouse livers with mTORC1 activation and defective autophagy. J Hepatol 2021 Oct 25;S0168-8278(21)02151-6. PMID: 34710483. DOI: 10.1016/j.jhep.2021.10.014.
Ouyang X, Becker E Jr, Bone NB, Johnson MS, Craver J, Zong WX, Darley-Usmar VM, Zmijewski JW, Zhang J. ZKSCAN3 in severe bacterial lung infection and sepsis-induced immunosuppression. Lab Invest. 2021. Sep 9. PMID: 34504306. DOI: 10.1038/s41374-021-00660-z.
Hou K, Shen J, Yan J, Zhai C, Zhang J, Pan JA, Zhang Y, Jiang Y, Wang Y, Lin RZ, Cong H, Gao S, Zong WX*. Loss of TRIM21 alleviates cardiotoxicity by suppressing ferroptosis induced by the chemotherapeutic agent doxorubicin. EBioMedicine 69:103456 (2021). PMID: 34233258. DOI: 10.1016/j.ebiom.2021.103456.
Wang F#, Zhang Y# (co-first author), Shen J, Yang B, Dai W, Yan J, Maimouni S, Daguplo HQ, Coppola S, Gao Y, Wang Y, Du Z, Peng K, Liu H, Zhang Q, Tang F, Wang P, Gao S, Wang Y, Ding WX, Guo G, Wang F, and Zong WX*. The ubiquitin E3 ligase TRIM21 promotes hepatocarcinogenesis by suppressing the p62-Keap1-Nrf2 antioxidant pathway. Cell Mol Gastroenterol Hepatol. 11(5):1369-1385 (2021). PMID: 33482392. DOI: 10.1016/j.jcmgh.2021.01.007.
2020
Zhang S, Bao Y, Shen X, Pan Y, Sun Y, Xiao M, Chen K, Wei H, Zuo J, Saffen D, Zong WX, Sun Y, Wang Z, Wang Y. RNA binding motif protein 10 suppresses lung cancer progression by controlling alternative splicing of eukaryotic translation initiation factor 4H. EBioMedicine. 2020 Nov;6. 1:103067. PMID: 33130397. DOI: 10.1016/j.ebiom.2020.103067.
Tseng HC, Xiong W, Badeti S, Yang Y, Ma M, Liu T, Ramos CA, Dotti G, Fritzky L, Jiang JG, Yi Q, Guarrera J, Zong WX, Liu C, Liu D. Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma. Nat Communi 2020 Sep 23;11(1):4810. PMID: 32968061. doi: 10.1038/s41467-020-18444-2.
Su X, Chiles E, Maimouni S, Wondisford F, Zong WX, and Song C. In-source CID ramping (InCIDR) and covariant ion analysis of hydrophilic interaction chromatography (HILIC) metabolomics. Anal Chem 92:4829-4837. 2020 Apr 7. PMID: 32125145. DOI: 10.1021/acs.analchem.9b04181.
Bhattacharya M, Dragan M, Nguyen MU, Guzman S, Goertzen C, Brackstone M, Dhillo W, Bech P, Clarke S, Abbara A, Tuck A, Hess D, Pine S, Zong WX, Wondisford F, Su X, and Babwah A. G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer. Cell Death Dis.11:106. (2020). PMID: 32034133. DOI: 10.1038/s41419-020-2305-7.
2019
Bott AJ, Maimouni S, and Zong WX*. The pleiotropic effects of glutamine metabolism in cancer. Cancers 11: pii: E770 (2019). PMID: 31167399. DOI: 10.3390/cancers11060770.
Dong Y, Hu Y, Sarkar S, Zong WX, Li M, Feng D, Song JX, Li M, Medina DL, Tan J, Zhang Z, Yue Z, Lu JH. Autophagy modulator scoring system: a user-friendly tool for quantitative analysis of methodological integrity of chemical autophagy modulator studies. Autophagy 2019 Dec 23:1-8. PMID: 31841063. DOI: 10.1080/15548627.2019.1704119.
Bott AJ, Shen J, Tonelli C, Zhan L, Sivaram N, Jiang YP, Yu X, Bhatt V, Chiles E, Zhong H, Maimouni S, Dai W, Velasquez S, Pan JA, Muthalagu N, Morton J, Anthony TG, Feng H, Lamers WH, Murphy D, Guo JY, Jin J, Crawford HC, Zhang L, White E, Lin RZ, Su X, Tuveson D, and Zong WX*. Glutamine anabolism plays a critical role in pancreatic cancer by coupling carbon and nitrogen metabolism. Cell Rep 29:1287-1298. (2019). PMID: 31665640. DOI: 10.1016/j.celrep.2019.09.056.
Ni HM, Chao X, Yang H, Deng F, Wang S, Bai Q, Qian H, Cui Y, Cui W, Shi Y, Zong WX, Yang L, Wang Z, and Ding WX. Dual roles of mTOR in regulating liver injury and tumorigenesis in autophagy defective mouse liver. Hepatology 70:2142-2155. (2019). PMID: 31095752. DOI: 10.1002/hep.30770.
Xu M, Almasi S, Yang Y, Yan C, Sterea AM, Rizvi Syeda AK, Shen B, Richard Derek C, Huang P, Gujar S, Wang J, Zong WX, Trebak M, El Hiani Y, Dong XP. The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways. Cell Calcium 79:80-88. (2019). PMID: 30889511. DOI: 10.1016/j.ceca.2019.02.010.
2018
Khambu B, Huda N, Chen X, Antoine DJ, Li Y, Dai G, Köhler UA, Zong WX, Waguri S, Werner S, Oury TD, Dong Z, Yin XM. HMGB1 promotes ductular reaction and tumorigenesis in autophagy-deficient livers. J Clin Invest. 128:2419-2435. (2018). PMID: 29558368. DOI: 10.1172/JCI91814.
2017
Law F, Seo JH, Wang Z, DeLeon JL, Bolis Y, Brown A, Zong WX, Du G, Rocheleau CE. The VPS34 PI3K negatively regulates RAB-5 during endosome maturation. J Cell Sci. 130:2007-2017. (2017). PMID: 28455411. DOI: 10.1242/jcs.194746.
Liu S, Jiang YP, Ballou LM, Zong WX, Lin RZ. Activation of Gαq in Cardiomyocytes Increases Vps34 Activity and Stimulates Autophagy. J Cardiovasc Pharmacol 69:198-211. (2017). PMID: 28376509. DOI: 10.1097/FJC.0000000000000461.
Li Y, Zong WX, Ding WX. Recycling the danger via lipid droplet biogenesis after autophagy. Autophagy 2017 Sep 5:1-3. PMID: 28873005. DOI: 10.1080/15548627.2017.1371394.
Sun Y, Sheshardri N, and Zong WX*, SERPINB3 and B4: from biochemistry to biology. Seminars in Cell and Developmental Biology 62:170-177. (2017). PMID: 27637160. DOI: 10.1016/j.semcdb.2016.09.005.
2016
Jaber N, Mohd-Naim N, Wang Z, DeLeon JL, Kim S, Zhong H, Sheshadri N, Dou Z, Edinger AL, Du G, Braga VMM, and Zong WX*. Vps34 regulates Rab7 and late endocytic trafficking through recruitment of the GTPase activating protein Armus. J Cell Sci 129: 4424-4435. (2016). PMID: 27793976. DOI: 10.1242/jcs.192260.
PanJA, SunY, JiangYP, BottAJ, JaberN, DouZ, YangB, ChenJS, CatanzaroJM, DuC, DingWX, Diaz-MecoMT,MoscatJ, OzatoK, LinRZ, and Zong WX*. TRIM21 ubiquitylates SQSTM1/p62 and suppresses protein sequestration to regulate redox homeostasis. Mol Cell 61: 720-733. “Featured Article”. (2016). PMID: 26942676. DOI: 10.1016/j.molcel.2016.02.007.
Zong WX, Rabinowitz JD, and White E. Mitochondria and cancer. Mol Cell 61: 667-676. (2016). PMID: 26942671. DOI: 10.1016/j.molcel.2016.02.011.
Klionsky D, et al., Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy (3rd edition). Autophagy 12:1-222. (2016). PMID: 26799652. DOI: 10.1080/15548627.2015.1100356.
2015
Bott AJ#, Peng IC# (co-first author), Fan Y, Faubert B, Zhao L, Li J, Neidler S, Sun Y, Jaber N, Krokowski D, Lu W, Pan JA, Powers S, Rabinowitz J, Hatzoglou M, Murphy DJ, Jones R, Wu S, Girnun G, and Zong WX*. Oncogenic Myc induces expression of glutamine synthetase through promoter demethylation. Cell Metab 22:1068-1077. (2015). PMID: 26603296. DOI: 10.1016/j.cmet.2015.09.025.
Dou Z, Xu C , Donahue G, Shimi T, Pan JA, Zhu J, Ivanov A, Capell B, Drake A, Shah P, Catanzaro J, Ricketts M, Lamark T, Adam S, Marmorstein R, Zong WX, Johansen T, Goldman R, Adams P, Berger S. Autophagy mediates degradation of nuclear lamina. Nature 527:105-109. (2015). PMID: 26524528. DOI: 10.1038/nature15548.
Naguib A, Bencze G, Cho H, Zheng W, Tocilj A, Elkayam E, Faehnle CR, Jaber N, Pratt CP, Chen M, Zong WX, Marks MS, Joshua-Tor L, Pappin DJ, and Trotman LC. PTEN function by recruitment to cytoplasmic vesicles. Mol Cell 16:255-268. (2015). PMID: 25866245. DOI: 10.1016/j.molcel.2015.03.011.
2014
Sheshadri N#, Catanzaro JM# (co-first author), Bott A, Sun Y, Ullman E, Wu S, Pan JA, Chen E, Crawford HC, Zhang J, and Zong WX*. SCCA1/SERPINB3 promotes oncogenesis and epithelial-mesenchymal transition via the unfolded protein response and IL6 signaling. Cancer Res 74:6318-6329. (2014). PMID: 25213322. DOI: 10.1158/0008-5472.CAN-14-0798.
McKnight NC, Zhong Y, Wold MS, Gong S, Phillips GR, Dou Z, Zhao Y, Heintz N, Zong WX, and Yue Z. Beclin 1 Is Required for Neuron Viability and Regulates Endosome Pathways via the UVRAG-VPS34 Complex. PLoS Genetics 10:e1004626. (2014). PMID: 25275521. DOI: 10.1371/journal.pgen.1004626.
Lu J, He L, Behrends C, Araki M, Araki K, Wang QJ, Catanzaro JM, Friedman SL, Zong WX, Fiel MI, Li M, and Yue Z. NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity. Nat Commun 5:3920. (2014). PMID: 24849286. DOI: 10.1038/ncomms4920.
Catanzaro JM#, Sheshadri N# (co-first author), Pan JA, Sun Y, Shi C, Li J, Powers RS, Crawford HC, and Zong WX*. Oncogenic Ras induces inflammatory cytokine production by upregulating the squamous cell carcinoma antigens SerpinB3/B4. Nat Commun 5: 3729. (2014). PMID: 24759783. DOI: 10.1038/ncomms4729.
Doyle CP, Pan JA, Mena P, Zong WX, Thanassi DG. TolC-Dependent Modulation of Host Cell Death by the Francisella tularensis Live Vaccine Strain. Infect Immun 82:2068-2078. (2014). PMID: 24614652. DOI: 10.1128/IAI.00044-14.
Catanzaro JM, Sheshadri N, and Zong WX*. SerpinB3/B4: mediators of Ras-driven inflammation and oncogenesis. Cell Cycle 13:3155-3156. (2014). PMID: 25485489. DOI: 10.4161/15384101.2014.969991.
Kepp O et al. Consensus guidelines for the detection of immunogenic cell death. Oncoimmunology in press. (2014). PMID: 25941621. DOI: 10.4161/21624011.2014.955691.
2013
Parekh VV, Wu L, Boyd KL, Williams JA, Gaddy JA, Olivares-Villagómez D, Cover TL, Zong WX, Zhang J, and Van Kaer L. Impaired autophagy, defective T cell homeostasis and a wasting syndrome in mice with a T cell-specific deletion of Vps34. J Immunol 190:5086-5101. (2013). PMID: 23596309. DOI: 10.4049/jimmunol.1202071.
Dou Z, Pan JA, Dbouk HA, Ballou LM, DeLeon JL, Fan YJ, Chen JS, Liang Z, Li G, Backer JM, Lin RZ, and Zong WX*. Class IA PI3 p110β subunit promotes autophagy through Rab5 small GTPase in response to growth factor limitation. Mol Cell 50:29-42. (2013). PMID: 23434372. DOI: 10.1016/j.molcel.2013.01.022.
Fan Y and Zong WX*. The cellular decision between apoptosis and autophagy. Chin J Cancer 32:121-129. (2013). PMID: 23114086. DOI: 10.5732/cjc.012.10106.
Pan JA. Fan Y. Gandhirajan RK, Madesh M. and Zong WX*. Hyperactivation of the mammalian degenerin MDEG promotes caspase-8 activation and apoptosis. J Biol Chem 288:2952-2963. (2013) (editorially selected as “Paper-of-the-week”). PMID: 23239879. DOI: 10.1074/jbc.M112.441063.
2012
Klionsky D, et al., Guidelines for the Use and Interpretation of Assays for Monitoring Autophagy in Higher Eukaryotes. Autophagy.8:445-544. (2012). PMID: 22966490. DOI: 10.4161/auto.19496.
Jaber N, Dou Z, Lin RZ, Zhang J, and Zong WX*. Mammalian PIK3C3/VPS34: the key to autophagic processing in liver and heart. Autophagy 8: 707-708. (2012). PMID: 22498475. DOI: 10.4161/auto.19627.
Guerriero JL, Ditsworth D, and Zong WX*. Non-apoptotic routes to defeat cancer. Oncoimmunology 1:94-96. (2012). PMID: 22720222. DOI: 10.4161/onci.1.1.17885.
Jaber N, Dou Z, Chen JS, Catanzaro J, Jiang YP, Ballou LM, Selinger E, Ouyang X, Lin RZ, Zhang J* (co-corresponding author), and Zong WX*. Class III PI3K Vps34 plays an essential role in autophagy and in heart and liver function. PNAS 109:2003-2008. (2012). PMID: 22308354. DOI: 10.1073/pnas.1112848109.
2011
Dou Z, Pan JA, Lin RZ, Zong WX*. The beta identity of class I PtdIns3K: A positive role of p110β in autophagy revealed. Autophagy. 7:246-247. (2011). PMID: 21160279. DOI: 10.4161/auto.7.2.14346.
Pan JA, Ullman E, Dou Z, and Zong WX*. Inhibition of protein degradation induces apoptosis through a microtubule-associated protein 1 light chain 3-mediated activation of caspase-8 at intracellular membranes. Mol Cell Biol 31:3158-3170. (2011). PMID: 21628531. DOI: 10.1128/MCB.05460-11.
Ullman E, Pan JA, and Zong WX*. Squamous cell carcinoma antigen 1 promotes caspase-8-mediated apoptosis in response to endoplasmic reticulum stress while inhibiting necrosis induced by lysosomal injury. Mol Cell Biol 31:2902-2919. (2011). PMID: 21576355. DOI: 10.1128/MCB.05452-11.
Catanzaro JM#, Guerriero JL# (co-first author), Liu J, Ullman E, Sheshadri N, Chen JJ, and Zong WX*. Elevated expression of squamous cell carcinoma antigen (SCCA) is associated with human breast carcinoma. PLoS One 6: e19096. (2011). PMID: 21526154. DOI: 10.1371/journal.pone.0019096.
Guerriero JL, Ditsworth D, Catanzaro JM, Sabino G, Furie MB, Kew R, and Zong WX*. DNA alkylating therapy induces tumor regression through an HMGB1-mediated activation of innate immunity. J Immunol 186:3517-3626. (2011) (editorially selected as a “Featured Article”). PMID: 21300822. DOI: 10.4049/jimmunol.1003267.
Lin F, Ren XD, Pan Z, Macri L, Zong WX, Tonnesen MG, Rafailovich M, Bar-Sagi D, Clark RA. Fibronectin growth factor-binding domains are required for fibroblast survival. J Invest Dermatol 131(1):84-98. (2011). PMID: 20811396. DOI: 10.1038/jid.2010.253.
2010
Catanzaro J and Zong WX*. Pinpointing Pin1 in non-small cell lung carcinoma. Cancer Biol Ther 9:120-121. (2010). PMID: 20023388. DOI: 10.4161/cbt.9.2.10767.
Dou Z, Chattopadhyay M, Pan JA, Guerriero JL, Jiang YP, Ballou LM, Yue Z, Lin RZ, and Zong WX*. The Class IA phosphatidylinositol 3-kinase p110β subunit is a positive regulator of autophagy. J Cell Biol 191:827-843. (2010). PMID: 21059846. DOI: 10.1083/jcb.201006056.
Fan Y, Dickman K, and Zong WX*. Akt and c-Myc differentially activate cellular metabolic programs and prime cells to bioenergetic inhibition. J Biol Chem 285: 7324-7333. (2010). PMID: 20018866. DOI: 10.1074/jbc.M109.035584.
2009
Gruber J, Yong J, Zatechka DS, Sabin L, Zhang Z, Lum JJ, Kong M, Zong WX, Lau CK, Cherry S, Ihle J, Dreyfuss G, and Thompson CB. Ars2 links the nuclear cap binding complex to RNA interference and cell proliferation. Cell 138: 328-339. (2009). PMID: 19632182. DOI: 10.1016/j.cell.2009.04.046.
Madesh M#, Zong WX# (co-first author), Hawkins BJ, Ramasamy S, Venkatachalam T, Mukhopadhyay P, Doonan PJ, Irrinki KM, Rajesh M, Pacher P, and Thompson CB. Execution of superoxide-induced cell death by the proapoptotic Bcl-2-related proteins Bid and Bak. Mol Cell Biol 29:3099-3112. (2009). PMID: 19332555. DOI: 10.1128/MCB.01845-08.
2008
Guerriero JL, Ditsworth D, Fan Y, Zhao F, Crawford HC, Zong WX*. Chemotherapy induces tumor clearance independent of apoptosis. Cancer Res 68: 9595-9600. (2008). PMID: 19047135. DOI: 10.1158/0008-5472.CAN-08-2452.
Singer AJ, McClain SA, Taira BR, Guerriero JL, Zong WX. Apoptosis and necrosis in the ischemic zone adjacent to third degree burns. Acad Emerg Med 15: 549-54. (2008). PMID: 18616442. DOI: 10.1111/j.1553-2712.2008.00115.x.
Fan Y and Zong WX*. Hacking hexokinase halts tumor growth. Cancer Biol Ther 7:1136-1138. (2008). PMID: 18698161. DOI: 10.4161/cbt.7.7.6536.
Ullman E#, Fan Y# (co-first author), Stawowczyk M, Chen HM, Yue Z, and Zong WX*. Autophagy promotes necrosis in apoptosis-deficient cells in response to ER stress. Cell Death Diff 16:422-425. (2008). PMID: 17917679. DOI: 10.1038/sj.cdd.4402234.
Simmons MJ, Fan G, Zong WX, Degenhardt K, White E, and Gélinas C. Bfl-1/A1 functions, similar to Mcl-1, as a selective tBid and Bak antagonist. Oncogene 27:1421-1428. (2008). PMID: 17724464. DOI: 10.1038/sj.onc.1210771.
2007
Ditsworth D, Zong WX, and Thompson CB. Activation of poly(ADP)-ribose polymerase (PARP-1) induces release of the pro-inflammatory mediator HMGB1 from the nucleus. J Biol Chem 282:17845-17854. (2007). PMID: 17430886. DOI: 10.1074/jbc.M701465200.
Banga S, Gao P, Shen X, Fiscus V, Zong WX, Chen L, and Luo ZQ. Legionella pneumophila inhibits macrophage apoptosis by targeting pro-death members of the Bcl2 protein family. PNAS. 104:5121-5126. (2007). PMID: 17360363. DOI: 10.1073/pnas.0611030104.
2006
Ricci MS and Zong WX*. Chemotherapeutic approaches for targeting cell death pathways. The Oncologist 11: 342-357. (2006). PMID: 16614230. DOI: 10.1634/theoncologist.11-4-342.
Zong WX and Thompson CB. 2006. Necrotic death as a cell fate. Genes Dev 20:1-15. PMID: 16391229. DOI: 10.1101/gad.1376506.
Lei X, Chen Y, Du G, Yu W, Wang X, Qu H, Xia B, He H, Mao J, Zong WX, Liao X, Maryam M, Hao X and Chen Q. Gossypol induces Bax/Bak-independent activation of apoptosis and cytochrome C release via a conformational change in Bcl-2. FASEB J 20: 2147-2149. (2006). PMID: 16935937. DOI: 10.1096/fj.05-5665fje.
Muthumani K, Choo AY, Zong WX, Hwang DS, Premkumar A, Thieu PT, Muniswamy M, Thompson CB, and Weiner DB. The HIV-1 Vpr and glucocorticoid receptor complex is a gain-of-function interaction that prevents the nuclear localization of PARP-1. Nat Cell Biol 8:170-179. (2006). PMID: 16429131. DOI: 10.1038/ncb1352.
2005
Thompson CB, Bauer DE, Lum JJ, Hatzivassiliou G, Zong WX, Zhao F, Ditsworth D, Buzzai M, Lindsten T. How do cancer cells acquire the fuel needed to support cell growth? Cold Spring Harb Symp Quant Biol. 70:357-62. (2005). PMID: 16869772. DOI: 10.1101/sqb.2005.70.011.
Lindsten T, Zong WX, and Thompson CB. Defining the role of the Bcl-2 family of proteins in the nervous system. The Neuroscientist 11:10-15. (2005). PMID: 15632274. DOI: 10.1177/1073858404269267.
2004
Ditsworth D and Zong WX*. NF-kappaB: Key mediator of inflammation-associated cancer. Cancer Biol Ther 3: 1214-1216. (2004). PMID: 15611628. DOI: 10.4161/cbt.3.12.1391.
Zong WX*. Histone H1.2: Another Housekeeping Protein that Kills. Cancer Biol Ther 3, 42-43. (2004). PMID: 14726680. DOI: 10.4161/cbt.3.1.738.
Zong WX, Ditsworth D, Bauer DE, Wang ZQ, and Thompson CB. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev 18: 1272-1282. (2004). PMID: 15145826. DOI: 10.1101/gad.1199904.
Brunelle JK, Santore MT, Budinger GR, Tang Y, Barrett TA, Zong WX, Kandel E, Keith B, Simon MC, Thompson CB, Hay N, and Chandel NS. c-Myc sensitization to oxygen deprivation-induced cell death is dependent on Bax/Bak, but is independent of p53 and hypoxia-inducible factor-1. J Biol Chem 279, 4305-4312. (2004). PMID: 14627695. DOI: 10.1074/jbc.M312241200.
Schnepp RW, Mao H, Sykes SM, Zong WX, Silva A, La P, and Hua X. Menin induces apoptosis in murine embryonic fibroblasts. J Biol Chem 279, 10685-10691. (2004). PMID: 14688275. DOI: 10.1074/jbc.M308073200.
Melino G, Bernassola F, Ranalli M, Yee K, Zong WX, Corazzari M, Knight RA, Green DR, Thompson CB, and Vousden KH. p73 induces apoptosis via PUMA transactivation and Bax mitochondrial translocation. J Biol Chem 279, 8076-8083. (2004). PMID: 14634023. DOI: 10.1074/jbc.M307469200.
2003
Lindsten T, Golden JA, Zong WX, Minarcik J, Harris MH, and Thompson CB. The proapoptotic activities of Bax and Bak limit the size of the neural stem cell pool. J Neurosci 23, 11112-11119. (2003). PMID: 14657169. DOI: 10.1523/JNEUROSCI.23-35-11112.2003.
Johnson TR, Stone K, Nikrad M, Yeh T, Zong WX, Thompson CB, Nesterov A, and Kraft AS. The proteasome inhibitor PS-341 overcomes TRAIL resistance in Bax and caspase 9-negative or Bcl-xL overexpressing cells. Oncogene 22, 4953-4963. (2003). PMID: 12902978. DOI: 10.1038/sj.onc.1206656.
Zong WX#, Li C# (co-first author), Hatzivassiliou G, Lindsten T, Yu QC, Yuan J, and Thompson CB. Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis. J Cell Biol 162, 59-69. (2003). PMID: 12847083. DOI: 10.1083/jcb.200302084.
2002
Rathmell JC, Lindsten T, Zong WX, Cinalli RM, and Thompson CB. Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. Nat Immunol 3, 932-939. (2002). PMID: 12244308. DOI: 10.1038/ni834.
Suh J, Payvandi F, Edelstein LC, Amenta PS, Zong WX, Gelinas C, and Rabson AB. Mechanisms of constitutive NF-kappaB activation in human prostate cancer cells. Prostate 52, 183-200. (2002). PMID: 12111695. DOI: 10.1002/pros.10082.
Lei K, Nimnual A, Zong WX, Kennedy NJ, Flavell RA, Thompson CB, Bar-Sagi D, and Davis RJ. The Bax subfamily of Bcl2-related proteins is essential for apoptotic signal transduction by c-Jun NH(2)-terminal kinase. Mol Cell Biol 22, 4929-4942. (2002). PMID: 12052897. DOI: 10.1128/MCB.22.13.4929-4942.2002.
McClintock DS, Santore MT, Lee VY, Brunelle J, Budinger GR, Zong WX, Thompson CB, Hay N, and Chandel NS. Bcl-2 family members and functional electron transport chain regulate oxygen deprivation-induced cell death. Mol Cell Biol 22, 94-104. (2002). PMID: 11739725. DOI: 10.1128/MCB.22.1.94-104.2002.
2001
Zong WX, Lindsten T, Ross AJ, MacGregor GR, and Thompson CB. BH3-only proteins that bind pro-survival Bcl-2 family members fail to induce apoptosis in the absence of Bax and Bak. Genes Dev 15, 1481-1486. (2001). PMID: 11410528. DOI: 10.1101/gad.897601.
Wei MC#, Zong WX# (co-first author), Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB, and Korsmeyer SJ. Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292, 727-730. (2001). PMID: 11326099. DOI: 10.1126/science.1059108.
2000
Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA, Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR, and Thompson CB. The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol Cell 6, 1389-1399. (2000). PMID: 11163212. DOI: 10.1016/s1097-2765(00)00136-2.
Luque I, Zong WX, Chen C, and Gelinas C. N-terminal determinants of I kappa B alpha necessary for the cytoplasmic regulation of c-Rel. Oncogene 19, 1239-1244. (2000). PMID: 10713713. DOI: 10.1038/sj.onc.1203400.
1999
Bash J, Zong WX, Banga S, Rivera A, Ballard DW, Ron Y, and Gelinas C. Rel/NF-kappaB can trigger the Notch signaling pathway by inducing the expression of Jagged1, a ligand for Notch receptors. EMBO J 18, 2803-2811. (1999). PMID: 10329626. DOI: 10.1093/emboj/18.10.2803.
Zong WX, Edelstein LC, Chen C, Bash J, and Gelinas C. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev 13, 382-387. (1999). PMID: 10049353. DOI: 10.1101/gad.13.4.382
1998
Zong WX, Bash J, and Gelinas C. Rel blocks both anti-Fas- and TNF alpha-induced apoptosis and an intact Rel transactivation domain is essential for this effect. Cell Death Diff 5, 963-972. (1998). PMID: 9846183. DOI: 10.1038/sj.cdd.4400441
1997
Bash J, Zong WX, and Gelinas C. c-Rel arrests the proliferation of HeLa cells and affects critical regulators of the G1/S-phase transition. Mol Cell Biol 17, 6526-6536. (1997). PMID: 9343416. DOI: 10.1128/MCB.17.11.6526
Zong WX, Farrell M, Bash J, and Gelinas C. v-Rel prevents apoptosis in transformed lymphoid cells and blocks TNFalpha-induced cell death. Oncogene 15, 971-980. (1997). PMID: 9285692. DOI: 10.1038/sj.onc.1201266
1995
Yeh CH, Zong WX, and Shatkin, AJ. The Ser36-Ser37 pair in HeLa nuclear protein p21/SIIR mediates Ser/Thr phosphorylation and is essential for Rous sarcoma virus long terminal repeat repression. J Biol Chem 270, 25313-25315. (1995). PMID: 7592688. DOI: 10.1074/jbc.270.43.25313.