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Speaker: Ashley Bernstein (Rutgers- New Brunswick)

Date: 12 Nov 2020

Title: ssNMR as a Tool to Examine Lipid Bilayers

PhD Candidate, Nieuwkoop Group

Lipid bilayers are the surface at which many important processes, such as protein binding and ion diffusion occur, and yet they are not well understood. Solid-state NMR (ssNMR) is a powerful and flexible technique that is well-equipped to study the structure and dynamics of a variety of systems, including lipid bilayers, at atomic resolution. A specific family of lipids, phosphatidylinositol phosphates (PIPs), are of particular interest due to their role in cell-signaling pathways and their binding specificity. Using 1H and 31P ssNMR, the behavior of PIPs can be examined in the presence of other lipids, ions, and binding proteins.