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Heart disease is a major health and economic burden worldwide and the leading cause of death in the United States. Although much progress has been made in understanding the causes of congenital heart disease, ischemic heart disease, and heart failure, the molecular underpinnings that contribute to this extraordinarily complex syndrome have yet to be fully elucidated. Our lab aims to better understand the molecular mechanisms responsible for heart injury and the progression to heart failure using a systems-based approach. Our long-term goal is to translate these findings to improved therapeutic approaches for patients.