Publications

Doshi, S. and Glytsou, C. (2025) Mitochondrial Dynamics in Blood Cancer Development and Progression. Current Pharmacology Reports https://doi.org/10.1007/s40495-025-00431-0, PMID: 41146909

Patel, C., Glytsou, C., Juang M.H., Cole, P. (2025) The effects of doxorubicin on blood-brain barrier integrity in hCMEC/D3. Neurotoxicology PMID: 41265652

La Vecchia, S., Doshi, S., Antonoglou, P., Kundu, T., Al Santli, W., Avrampou, K., Witkowski, M., Pellattiero, A., Magrin, F., Ames, K., Verma, A., Gritsman, K., Su, X., Mattarei, A., Aifantis, I., Scorrano, L., Glytsou, C. (2025) Small molecule OPA1 inhibitors reverse mitochondrial adaptations to overcome therapy resistance in acute myeloid leukemia. Science Advances  https://www.science.org/doi/10.1126/sciadv.adx8662, PMID: 41091864

Glaviano, A., Weisberg, E., Lam, H.Y., Tan, D.J.J., Innes, A., Ge, Y., Lai C.E., Stock, W., Glytsou, C., et al. (2025) Apoptosis-targeting BH3 mimetics: transforming treatment for patients with acute myeloid leukaemia. Nat Rev Clin Oncol https://doi.org/10.1038/s41571-025-01068-0, PMID: 40890352

Glytsou, C. (2025) Electron Microscopy to Visualize and Quantify Mitochondrial Structure and Organellar Interactions in Cultured Cells During Senescence. Methods Mol Biol. 2025;2906:229-242. doi: 10.1007/978-1-0716-4426-3_13. PMID: 40082359

Rigoni, G.*, Calvo, E.*, Glytsou, C.*, Carro-Alvarellos, M., Noguchi, M., Semenzato, M., Quirin, C., Caicci, F., Meneghetti, N., Sturlese, M., Ishihara, T., Moro, S., Rampazzo, C., Ishihara, N., Bezzo, F., Salviati, L., Vazquez, J., Sales, G., Romualdi, C., Enriquez, J. A., Scorrano, L., & Soriano, M. E. (2025). MARIGOLD and MitoCIAO, two searchable compendia to visualize and functionalize protein complexes during mitochondrial remodeling. Cell Metabolism doi.org/10.1016/j.cmet.2025.01.017. PMID: 39999845 (*equal contribution)

Romo-Gonzalez, M., Kundu, T., Diaz-Rubio, M.E., Su, X., McBride, M.J., Glytsou, C. (2024) Countering development of resistance to treatment in AML by targeting metabolic adaptations. Blood (66^th Annual Meetings Abstract, Supplement 1). https://doi.org/10.1182/blood-2024-211612

Glytsou, C.^#, *, Chen, X.*, Zacharioudakis, E.*, Al-Santli, W., Zhou, H., Sun, Z., Zal, T., Zal, M.A., Ishizawa, J., Tibes, R., Tsirigos, A., Andreeff. M., Gavathiotis, E.^#, Aifantis, I^#. (2023). Mitophagy promotes resistance to BH3 mimetics in acute myeloid leukemia. Cancer Discovery doi:10.1158/2159-8290.CD-22-0601. PMCID: PMC10330144. (^#Corresponding authors; *equal contribution)

Chen, X.*, Glytsou, C.*, Zhou, H., Narang, S., Reyna, D.E., Lopez, A., Sakellaropoulos, T., Gong, Y., Kloetgen, A., Yap, Y.S., Wang, E., Gavathiotis, E., Tsirigos, A., Tibes, R., and Aifantis, I. (2019). Targeting Mitochondrial Structure Sensitizes Acute Myeloid Leukemia to Venetoclax Treatment. Cancer Discovery 9, 890-909. doi: 10.1158/2159-8290.CD-19-0117. PMC ID: PPMC6606342 (*equal contribution)

Commentary – Savona MR, Rathmell JC. (2019). Mitochondrial Homeostasis in AML and Gasping for Response in Resistance to BCL2 Blockade. Cancer Discov 9, 831-33. doi:10.1158/2159-8290.CD-19-0510.

Thandapani, P., Kloetgen, A.*, Witkowski, M.T.*, Glytsou, C.*, Lee, A.K., Wang, E., Wang, J., LeBoeuf, S.E., Avrampou, K., Papagiannakopoulos, T., Tsirigos, A., and Aifantis, I. (2021). Valine tRNA levels and availability regulate complex I assembly in leukaemia. Nature. doi: 10.1038/s41586-021-04244-1. PMCID: PMC9116157. (*equal contribution)

DiNardo, C.D., Tiong, I.S., Quaglieri, A., MacRaild, S., Loghavi, S., Brown, F.C., Thijssen, R., Pomilio, G., Ivey, A., Salmon, J.M., Glytsou, C., Fleming, S.A., Zhang, Q., Ma, H., Patel, K.P., Kornblau, S.M., Xu, Z., Chua, C.C., Chen, X., Blombery, P., Flensburg, C., Cummings, N., Aifantis, I., Kantarjian, H., Huang, D.C.S., Roberts, A.W., Majewski, I.J., Konopleva, M., and Wei, A.H. (2020). Molecular patterns of response and treatment failure after frontline venetoclax combinations in older patients with AML. Blood 135, 791-803. doi: 10.1182/blood.2019003988. PMCID: PMC7068032.

Giacomello, M., Pyakurel, A., Glytsou, C., and Scorrano, L. (2020). The cell biology of mitochondrial membrane dynamics. Nat Rev Mol Cell Biol 21, 204-224. doi: 10.1038/s41580-020-0210-7. PMCID: 32071438.

Glytsou, C., Calvo, E., Cogliati, S., Mehrotra, A., Anastasia, I., Rigoni, G., Raimondi, A., Shintani, N., Loureiro, M., Vazquez, J., Pellegrini, L., Enriquez, J.A., Scorrano, L., and Soriano, M.E. (2016). Optic Atrophy 1 Is Epistatic to the Core MICOS Component MIC60 in Mitochondrial Cristae Shape Control. Cell Reports 17, 3024-3034. doi: 10.1016/j.celrep.2016.11.049. PMCID: PMC5186903.

Quintana-Cabrera, R., Quirin, C., Glytsou, C., Corrado, M., Urbani, A., Pellattiero, A., Calvo, E., Vazquez, J., Enriquez, J.A., Gerle, C., Soriano, M.E., Bernardi, P. and Scorrano, L. (2018). The cristae modulator Optic atrophy 1 requires mitochondrial ATP synthase oligomers to safeguard mitochondrial function. Nat Commun 9, 3399. doi: 10.1038/s41467-018-05655-x. PMCID: PPMC6109181

Galanos, P., Pappas, G., Polyzos, A., Kotsinas, A., Svolaki, I., Giakoumakis, N.N., Glytsou, C., Pateras, I.S., Swain, U., Souliotis, V.L., Georgakilas, A.G., Geacintov, N., Scorrano, L., Lukas, C., Lukas, J., Livneh, Z., Lygerou, Z., Chowdhury, D., Sorensen, C.S., Bartek, J., and Gorgoulis, V.G. (2018). Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability. Genome Biol 19, 37. doi: 10.1186/s13059-018-1401-9. PMCID: PPMC5857109

Aivaliotis, I.L., Pateras, I.S., Papaioannou, M., Glytsou, C., Kontzoglou, K., Johnson, E.O., and Zoumpourlis, V. (2012). How do cytokines trigger genomic instability? J Biomed Biotechnol 2012, 536761. doi: 10.1155/2012/536761. PMCID: PPMC3382994