Joseph Moloughney

Publications:

Moloughney, J.G., Vega-Cotto, N.M., Liu, S., Patel, C., Kim, P.K., Wu, C., Albaciete, D., Magaway, C., Chang, A., Rajput, S., Su, X., Werlen, G., and Jacinto, E. mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation.  J. Biol Chem. 2018, 293(42): 16464-16478, PMID 30201609

 

Moloughney, J.G.*, Kim, P.K.*, Vega-Cotto, N.M.*, Wu, C., Zhang, S., Adlam, M., Lynch, T., Chou, P.C., Rabinowitz, J.D., Werlen, G. and Jacinto, E. mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1. Molecular Cell 2016, 63, 811-826. PMID:27570073

 

Lynch, T., Moloughney, J., and Jacinto, E. The mTOR complexes in cancer cell metabolism., in PI3K-mTOR in cancer and cancer therapy 2016, Springer,  p. 29-63, ed. B. Leyland Jones, P. De, N. Dey,.

 

Chou, P.C., Moloughney, J., Oh, W.J., Wu, C.C., Chen, P.H., Ruegg, M., Hall, M.N., Jacinto, E.* and Werlen, G.* mTORC2 modulates alpha/beta T cell receptor processing and surface expression during thymocyte development., J. Immunol. 2014,  193, 1162-1170.  PMID: 24981454 *co-corresponding authors