Publications

 

Ragupathi, A., Kim, C., and Jacinto, E. The mTORC2 signaling network: targets and cross-talks, Biochem. J. 2024, 481: 45-91. PMID: 38270460

 

Jacinto, E. mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination, Cell Metab 2023, 35(12):2097-2099. PMID: 38056426

 

Patel, N. and Jacinto, E. The mTOR complexes: Coordinating metabolism and translation, RNA-based Mechanisms in Cancer, pp243-302 (2023), World Scientific

 

Paneque, A., Fortus, H., Zheng, J., Werlen, G., and Jacinto, E. The hexosamine biosynthesis pathway: regulation and function, Genes 2023, 14(4),933.

 

Werlen, G., Li, M.L., Tottone, L., da Silva-Diz, V., Su, X., Herranz, D., and Jacinto, E. Dietary glucosamine overcomes the defects in alpha/beta-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis, Nature Comm. 2022, 13, 7404

 

Li, M.L., Ragupathi, A., Patel, N., Hernandez, T., Magsino, J., Werlen, G., Brewer, G. and Jacinto, E. The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane. J. Biol. Chem. 2022 298(10):102437. PMID: 36041631

 

Werlen, G., Jain, R. and Jacinto, E. mTOR signaling and metabolism in early T cell development. Genes 2021, 12, 728.

 

Szwed, A., Kim, E. and Jacinto, E. Regulation and metabolic functions of mTORC1 and mTORC2., Physiol. Rev. 2021, 101(3):1371-1426 PMID: 33599151

 

Chi, O.Z., Chiricolo, A. Liu, X., Patel, N., Jacinto E., and Weiss, H.R. Inhibition of serum and glucocorticoid regulated kinases by GSK650394 reduced infarct size in early cerebral ischemia-reperfusion with decreased BBB disruption. Neurosci. Lett 2021, 762:136143, PMID: 34332027

 

Chi, O.Z., Liu, X., Cofano, S., Patel, N., Jacinto, E., and Weiss, H.R. Rapalink-1 increased infarct size in early cerebral ischemia-reperfusion with increased blood-brain barrier disruption. Front. Phys. 2021, 12:706528, doi: 10.3389/fphys.2021.706528.

 

Ye, C., Liu, B., Lu, H., Liu, J., Rabson, A.B., Jacinto, E., Pestov, D.G., and Shen, Z. BCCIP is required for nucleolar recruitment of eIF6 and 12s pre-rRNA production during 60S ribosome biogenesis. Nucleic Acids Res. 2020, 48(22):12817-12832 PMID: 33245766

 

Chi, O.Z., Mellender, S.J., Kiss, G.K., Chiricolo, A., Liu, X., Patel, N., Jacinto, E., and Weiss, H.R. Lysophosphatidic acid increased infarct size in the early stage of cerebral ischemia-reperfusion with increased BBB permeability. J. Stroke Cerebrovasc Dis. 2020, 29(10):105029 PMID: 32912542

 

Chou, P.C., Rajput, S., Zhao, X., Patel, C., Albaciete, D., Oh, W.J., Daguplo, H.Q., Patel, N., Su,, B., Werlen, G., and Jacinto, E. mTORC2 is involved in the induction of RSK phosphorylation by serum or nutrient starvation. Cells 2020, 9(7):E1567, PMID:32605013

 

La Manna, F., De Menna, M., Patel, N., Karkampouna, S., De Filippo, M., Klima, I., Kloen, P., Beimers, L., Thalmann, G.N., Pelger, R.C.M., Jacinto, E., and Kruithof-de Julio, M. Dual mTOR inhibitor Rapalink-1 reduces prostate cancer patient-derived xenograft growth and alters tumor heterogeneity. Front. Onc. 2020, 10:1012. PMID:32656088

 

Cordover, E., Wei, J., Patel, C., Shen, N.L., Gionco, J., Sargsyan, D., Wu, R., Cai, L., Kong, A.T., Jacinto, E, and Minden, A. KPT_9274, an inhibitor of PAK4 and NAMPT, leads to downregulation of mTORC2 in triple negative breast cancer cells. Chem. Res. Toxicol. 2019, PMID: 31876149

 

Magaway, C., Kim, E., and Jacinto, E. Targeting mTOR and metabolism in cancer:  Lessons and Innovations.  Cells 2019, 8(12). Pii:E1584. PMID: 31817676

 

Jacinto, E.  The young and the restless: Isolating the dynamic mammalian pre-ribosomes, J. Biol. Chem., 2019, 294(28): 10758-10759. PMID 31300590.

 

Jacinto, E.  Amplifying mTORC2 signals through AMPK during energy stress., Science Sig. 2019, 12(585). PMID 31186374

 

Chi, O.Z., Kiss, G.K., Mellender, S.J., Liu, X., Liu, S., Jacinto, E., and Weiss, H. Inhibition of p70 ribosomal S6 kinase (S6K1) by PF-4708671 decreased infarct size in early cerebral ischemia-reperfusion with decreased BBB permeability. Eur. J. Pharmacol. 2019, 855:202-207. PMID:31063769

 

Moloughney, J.G., Vega-Cotto, N.M., Liu, S., Patel, C., Kim, P.K., Wu, C., Albaciete, D., Magaway, C., Chang, A., Rajput, S., Su, X., Werlen, G., and Jacinto, E. mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation.  J. Biol Chem. 2018, 293(42): 16464-16478, PMID 30201609

 

Weiss, H.R., Chi, O.Z., Kiss, G.K., Liu, X., Damito, S., and Jacinto E., Akt activation improves microregional oxygen supply/consumption balance after cerebral ischemia-reperfusion. Brain Res. 2018 1683:48-54. PMID 29371097

 

Moloughney, J.G.*, Kim, P.K.*, Vega-Cotto, N.M.*, Wu, C., Zhang, S., Adlam, M., Lynch, T., Chou, P.C., Rabinowitz, J.D., Werlen, G. and Jacinto, E. mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1. Molecular Cell 2016, 63, 811-826. PMID:27570073

 

Chi, O.Z., Barsoum, S., Vega-Cotto, N.M., Jacinto, E., Liu X., Mellender, S.J., and Weiss, H.R. Effects of rapamycin on cerebral oxygen supply and consumption during reperfusion after cerebral ischemia, Neuroscience 2016 316:321-7. PMID 26742793

 

Tobias, I., Kaulich, M., Kim, P.K., Simon, N., Jacinto, E., Dowdy, S., King, C.C., and Newton, AC. Protein kinase C z exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation, Biochem J 2016, 473(4):509-23.  PMID: 26635352

 

Lynch, T., Moloughney, J., and Jacinto, E. The mTOR complexes in cancer cell metabolism., in PI3K-mTOR in cancer and cancer therapy 2016, Springer,  p. 29-63, ed. B. Leyland Jones, P. De, N. Dey,.

 

Jacinto, E. and Werlen, G. mTOR: The mTOR complexes in T cell development and immunity, in Encyclopedia of Inflammatory Diseases 2015, ed. M.J. Parnham, Springer.

 

Chi, O.Z., Wu, C.C., Liu, X., Rah, K.H., Jacinto, E., and Weiss, H.R., Restoration of cerebral oxygen consumption with rapamycin treatment in a rat model of autism-tuberous sclerosis, Neuromolecular Medicine 2015, 17(3):305-13. PMID: 26048361

 

Chou, P.C., Moloughney, J., Oh, W.J., Wu, C.C., Chen, P.H., Ruegg, M., Hall, M.N., Jacinto, E.* and Werlen, G.* mTORC2 modulates alpha/beta T cell receptor processing and surface expression during thymocyte development., J. Immunol. 2014,  193, 1162-1170.  PMID: 24981454 *co-corresponding authors

 

DeStefano, M.A. and Jacinto, E. Regulation of insulin receptor substrate-1 by mTORC2. Biochem. Soc. Trans. 2013;  41, 896-901. PMID: 23142081

 

Kim, S.J*., DeStefano, M.A.*, Oh, W.J., Wu, C., Vega-Cotto, N.M., Finlan, M., Liu, D., Su, B., and Jacinto, E. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase Fbw8.  Molecular Cell 2012; 48, 875-887.  PMID: 23142081

 

Wu, C., Chou, P., and Jacinto, E.  The target of rapamycin; structure and functions, in Protein Kinases 2012, Intech Publishing, p1-40, ed. Xavier, G.

 

Su, B., and Jacinto, E.  mTOR signaling to the AGC kinases.  Crit. Rev. in Biochem. and Molec. Biol. 2011, 46, 527-547.

 

Jacinto, E.  TFEBulous control of traffic by mTOR.  EMBO J. 2011, 30, 3215-3216

 

Oh, W., and Jacinto, E.  mTOR complex 2 signaling and functions.  Cell Cycle 2011; 10, 1-12. PMID: 21670596

 

Oh, W*., Wu, C.*, Kim, S.J., Facchinetti, V., Julien, L.A., Finlan, M., Roux, P.P., Su, B., and Jacinto, E. mTORC2 associates with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010; 29, 3939-3951. PMID: 21045808

 

Jacinto, E.  AGC kinases in mTOR signaling.  Ed. M. Hall and F. Tamanoi: The Enzymes 2010; 27, 101-128. Burlington: Academic Press.  PMID: 18215152

 

Facchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A., Gould, C., Lowry, C., Newton, A.C., Mao, Y., Miao, R.Q., Sessa, W.C., Qin, J., Zhang, P., Su, B., and Jacinto, E. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 2008; 27, 1932-1943. PMID: 18566586

 

Jacinto, E., and Lorberg, A.  TOR regulation of AGC kinases in yeast and mammals.   Biochem. J. 2008; 410, 19-37.  PMID:18215152

 

Jacinto, E.  What controls TOR?  IUBMB Life 2008; 60, 483-96.  PMID: 18493947

 

Jacinto, E. *, Facchinetti*, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., Huang, Q., Qin, J., and Su, B. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006; 127, 125-137. PMID: 16962653

 

Jacinto, E. Phosphatase targets in TOR signaling.  Ed. G. Moorhead, Methods Mol. Biol 2006; 365, 323-334.  Humana Press Inc., Totowa, NJ.  PMID: 17200572

 

Jacinto, E.*, Loewith, R.*, Schmidt, A., Lin, S., Ruegg, M., Hall, A., and Hall, M.N. Mammalian TOR complex 2 (mTORC2) controls the actin cytoskeleton and is rapamycin insensitive. Nature Cell Biology 2004; 6, 1122-1128.  PMID: 15467718 *equal contribution

 

Jacinto, E., and Hall, M.N.  TOR signaling in bugs, brain, and brawn.  Nature Reviews (Mol. Cell. Biol.) 2003; 4, 117-126. PMID: 12563289

 

Bonenfant, D., Schmelzle, T., Jacinto, E., Crespo, J.L., Mini, T., Hall, M.N., and Jenoe, P. Quantitation of changes in site specific phosphorylation: a simple method based on stable isotope labelling and mass spectrometry. Proc. Natl. Acad. Sci. 2003; 100, 880-885. PMID: 12540831

 

Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J.L., Bonenfant, D., Oppliger, W., Jenoe, P., and Hall, M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Molecular Cell 2002; 10, 457-468. PMID:12408816

 

Jacinto, E., Guo, B., Arndt, K.T., Schmelzle, T., and Hall, M.N. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Molecular Cell 2001;  8, 1017-1026. PMID: 11741537

 

Werlen, G., Jacinto, E., Xia, Y., and Karin, M. Calcineurin preferentially synergizes with PKC-theta to activate JNK in T lymphocytes. EMBO J 1998; 17, 3101-3111. PMID: 9606192

 

Jacinto, E., Werlen, G., and Karin, M. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity 1998;  8, 31-41. PMID: 9462509

 

Wu, Z., Wu, J., Jacinto, E., and Karin, M. Molecular cloning and characterization of human JNKK2, a novel Jun N-terminal kinase (JNK)-specific kinase. Mol. Cell. Biol 1997;  17, 7407-7416. PMID: 9372971

 

Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994; 77, 727-736. PMID: 8205621

 

Jacinto, E. Signal integration in T lymphocytes: The role of JNK and ERK. Dissertation (UCSD) 1997