Chang-chih Wu

Publications:

Moloughney, J.G., Vega-Cotto, N.M., Liu, S., Patel, C., Kim, P.K., Wu, C., Albaciete, D., Magaway, C., Chang, A., Rajput, S., Su, X., Werlen, G., and Jacinto, E. mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation.  J. Biol Chem. 2018, 293(42): 16464-16478, PMID 30201609

 

Moloughney, J.G.*, Kim, P.K.*, Vega-Cotto, N.M.*, Wu, C., Zhang, S., Adlam, M., Lynch, T., Chou, P.C., Rabinowitz, J.D., Werlen, G. and Jacinto, E. mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1. Molecular Cell 2016, 63, 811-826. PMID:27570073

 

Chi, O.Z., Wu, C.C., Liu, X., Rah, K.H., Jacinto, E., and Weiss, H.R., Restoration of cerebral oxygen consumption with rapamycin treatment in a rat model of autism-tuberous sclerosis, Neuromolecular Medicine 2015, 17(3):305-13. PMID: 26048361

 

Chou, P.C., Moloughney, J., Oh, W.J., Wu, C.C., Chen, P.H., Ruegg, M., Hall, M.N., Jacinto, E.* and Werlen, G.* mTORC2 modulates alpha/beta T cell receptor processing and surface expression during thymocyte development., J. Immunol. 2014,  193, 1162-1170.  PMID: 24981454 *co-corresponding authors

 

Kim, S.J*., DeStefano, M.A.*, Oh, W.J., Wu, C., Vega-Cotto, N.M., Finlan, M., Liu, D., Su, B., and Jacinto, E. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase Fbw8.  Molecular Cell 2012; 48, 875-887.  PMID: 23142081

 

Wu, C., Chou, P., and Jacinto, E.  The target of rapamycin; structure and functions, in Protein Kinases 2012, Intech Publishing, p1-40, ed. Xavier, G.

 

Oh, W*., Wu, C.*, Kim, S.J., Facchinetti, V., Julien, L.A., Finlan, M., Roux, P.P., Su, B., and Jacinto, E. mTORC2 associates with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010; 29, 3939-3951. PMID: 21045808