Skip to main content

Mei-Ling Li

Mei-Ling obtained her B.S. from the National Taiwan Normal University and her Ph.D. from Rutgers Univ. She is currently a Research Asst. Prof. at the Dept. of Biochemistry and Mol. Biol. Mei-Ling is an accomplished virologist and biochemist.  With a strong background in translation mechanisms, she is currently extending her studies into mTOR signaling and metabolic regulation in T cells.

Representative Publications (total 39):

  1. Mei-Ling Li & Victor Stollar (1995). A mutant of Sindbis virus which is released efficiently from cells maintained in low ionic strength medium.  Virology, 210:237-243.
  2. Mei-Ling Li, Huey-Lan Wang, & Victor Stollar (1997). Complementation of and interference with Sindbis virus replication by full-length and deleted forms of the nonstructural protein, nsP1, expressed in stable transfectants of Hela cells.  Virology, 227:361-369.
  3. Mei-Ling Li, Bertha Cecilia Ramirez & Robert M. Krug (1998). RNA-dependent activation of primer RNA production by influenza polymerase: different regions of the same protein subunit constitute the two required RNA-binding sites. EMBO, 17:5844-5852.
  4. Mei-Ling Li, Huey-Jane Liao, Lee D. Simon & Victor Stollar (1999).  An amino acid change in the exodomain of the E2 protein of Sindbis virus, which impairs the release of virus from chicken cells but not from mosquito cells.  Virology, 264:187-194.
  5. Mei-Ling Li, Ping Rao & Robert M. Krug (2001). The active sites of influenza cap-dependent endonuclease are on different polymerase subunits.  EMBO, 20:2078-2086.
  6. Mei-Ling Li, Tsu-An Hsu, Tzu-Chun Chen, Shih-Cheng Chang, Jin-Ching Lee, Chiann-Chyi Chen, Victor Stollar & Shin-Ru Shih (2002).The 3C protease activity of enterovirus 71 induces human neural cell apoptosis.  Virology, 293:386-395.
  7. Mei-Ling Li and Victor Stollar. Identification of the amino acid sequence in the Sindbis virus nsP4 that binds to the promoter for the synthesis of the subgenomic RNA (2004). 101:9429-9434.
  8. Mei-Ling Li, Jennifer Defren, Gary Brewer (2013). Hsp27 and F-Box Protein β-TrCP Promote Degradation of mRNA Decay Factor AUF1. Mol Cell Biol. 33(11):2315-26. doi: 10.1128/MCB.00931-12.

  9. Jing-Yi Lin, Gary Brewer, and Mei-Ling Li (2015). HuR and Ago2 Bind the Internal Ribosome Entry Site of Enterovirus 71 and Promote Virus Translation and Replication. PLoS One. 2015 Oct 9;10(10):e0140291. doi: 10.1371/journal.pone.0140291.

  10. Mei-Ling Li, Jing-Yi Lin, Bo-Shiun Chen, Kuo-Feng Weng, Shin-Ru Shih, Jesse Davila Calderon, Blanton S Tolbert, Gary Brewer (2019). EV71 3C Protease Induces Apoptosis by Cleavage of hnRNP A1 to Promote apaf-1 Translation. PLoS One14 (9):e0221048. doi: 10.1371/journal.pone.0221048. eCollection 2019.

  11. Mei-Ling Li, Aparna Ragupathi, Nikhil Patel, Tatiana Hernandez, Jedrick Magsino, Guy Werlen, Gary Brewer, and Estela Jacinto (2022). The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane. J. Biol. Chem.298(10):102437
  12. Guy Werlen, Mei-Ling Li,  Luca Tottone, Victoria da Silva-Diz, Xiaoyang Su, Daniel Herranz, and Estela Jacinto (2022). Dietary glucosamine overcomes the defects in alpha/beta T cell ontogeny caused by the loss of de novo hexosamine biosynthesis. Nature Commun. 13(1):7404