Publications
Werlen, G., Hernandez, T. and Jacinto, E. Food for thought: Nutrient metabolism controlling early T cell development. Bioessays 2024 PMID: 39504233
Chi, O.Z., Liu, X., Fortus, H., Werlen, G.,Jacinto, E., and Weiss, H.R. Inhibition of p70 ribosomal S6 kinase (S6K1) reduces cortical blood flow in a rat model of autism-tuberous sclerosis.Neuromol. Med. 2024, 4:26(1):10, PMID: 3857042
Ragupathi, A., Kim, C., and Jacinto, E. The mTORC2 signaling network: targets and cross-talks, Biochem. J. 2024, 481: 45-91. PMID: 38270460
Jacinto, E. mTOR takes charge: Relaying uncharged tRNA levels by mTOR ubiquitination, Cell Metab 2023, 35(12):2097-2099. PMID: 38056426
Patel, N. and Jacinto, E. The mTOR complexes: Coordinating metabolism and translation, RNA-based Mechanisms in Cancer, pp243-302 (2023), World Scientific
Paneque, A., Fortus, H., Zheng, J., Werlen, G., and Jacinto, E. The hexosamine biosynthesis pathway: regulation and function, Genes 2023, 14(4),933.
Werlen, G., Li, M.L., Tottone, L., da Silva-Diz, V., Su, X., Herranz, D., and Jacinto, E. Dietary glucosamine overcomes the defects in alpha/beta-T cell ontogeny caused by the loss of de novo hexosamine biosynthesis, Nature Comm. 2022, 13, 7404
Li, M.L., Ragupathi, A., Patel, N., Hernandez, T., Magsino, J., Werlen, G., Brewer, G. and Jacinto, E. The RNA-binding protein AUF1 facilitates Akt phosphorylation at the membrane. J. Biol. Chem. 2022 298(10):102437. PMID: 36041631
Werlen, G., Jain, R. and Jacinto, E. mTOR signaling and metabolism in early T cell development. Genes 2021, 12, 728.
Szwed, A., Kim, E. and Jacinto, E. Regulation and metabolic functions of mTORC1 and mTORC2., Physiol. Rev. 2021, 101(3):1371-1426 PMID: 33599151
Chi, O.Z., Chiricolo, A. Liu, X., Patel, N., Jacinto E., and Weiss, H.R. Inhibition of serum and glucocorticoid regulated kinases by GSK650394 reduced infarct size in early cerebral ischemia-reperfusion with decreased BBB disruption. Neurosci. Lett 2021, 762:136143, PMID: 34332027
Chi, O.Z., Liu, X., Cofano, S., Patel, N., Jacinto, E., and Weiss, H.R. Rapalink-1 increased infarct size in early cerebral ischemia-reperfusion with increased blood-brain barrier disruption. Front. Phys. 2021, 12:706528, doi: 10.3389/fphys.2021.706528.
Ye, C., Liu, B., Lu, H., Liu, J., Rabson, A.B., Jacinto, E., Pestov, D.G., and Shen, Z. BCCIP is required for nucleolar recruitment of eIF6 and 12s pre-rRNA production during 60S ribosome biogenesis. Nucleic Acids Res. 2020, 48(22):12817-12832 PMID: 33245766
Chi, O.Z., Mellender, S.J., Kiss, G.K., Chiricolo, A., Liu, X., Patel, N., Jacinto, E., and Weiss, H.R. Lysophosphatidic acid increased infarct size in the early stage of cerebral ischemia-reperfusion with increased BBB permeability. J. Stroke Cerebrovasc Dis. 2020, 29(10):105029 PMID: 32912542
Chou, P.C., Rajput, S., Zhao, X., Patel, C., Albaciete, D., Oh, W.J., Daguplo, H.Q., Patel, N., Su,, B., Werlen, G., and Jacinto, E. mTORC2 is involved in the induction of RSK phosphorylation by serum or nutrient starvation. Cells 2020, 9(7):E1567, PMID:32605013
La Manna, F., De Menna, M., Patel, N., Karkampouna, S., De Filippo, M., Klima, I., Kloen, P., Beimers, L., Thalmann, G.N., Pelger, R.C.M., Jacinto, E., and Kruithof-de Julio, M. Dual mTOR inhibitor Rapalink-1 reduces prostate cancer patient-derived xenograft growth and alters tumor heterogeneity. Front. Onc. 2020, 10:1012. PMID:32656088
Cordover, E., Wei, J., Patel, C., Shen, N.L., Gionco, J., Sargsyan, D., Wu, R., Cai, L., Kong, A.T., Jacinto, E, and Minden, A. KPT_9274, an inhibitor of PAK4 and NAMPT, leads to downregulation of mTORC2 in triple negative breast cancer cells. Chem. Res. Toxicol. 2019, PMID: 31876149
Magaway, C., Kim, E., and Jacinto, E. Targeting mTOR and metabolism in cancer: Lessons and Innovations. Cells 2019, 8(12). Pii:E1584. PMID: 31817676
Jacinto, E. The young and the restless: Isolating the dynamic mammalian pre-ribosomes, J. Biol. Chem., 2019, 294(28): 10758-10759. PMID 31300590.
Jacinto, E. Amplifying mTORC2 signals through AMPK during energy stress., Science Sig. 2019, 12(585). PMID 31186374
Chi, O.Z., Kiss, G.K., Mellender, S.J., Liu, X., Liu, S., Jacinto, E., and Weiss, H. Inhibition of p70 ribosomal S6 kinase (S6K1) by PF-4708671 decreased infarct size in early cerebral ischemia-reperfusion with decreased BBB permeability. Eur. J. Pharmacol. 2019, 855:202-207. PMID:31063769
Moloughney, J.G., Vega-Cotto, N.M., Liu, S., Patel, C., Kim, P.K., Wu, C., Albaciete, D., Magaway, C., Chang, A., Rajput, S., Su, X., Werlen, G., and Jacinto, E. mTORC2 modulates the amplitude and duration of GFAT1 Ser243 phosphorylation to maintain flux through the hexosamine pathway during starvation. J. Biol Chem. 2018, 293(42): 16464-16478, PMID 30201609
Weiss, H.R., Chi, O.Z., Kiss, G.K., Liu, X., Damito, S., and Jacinto E., Akt activation improves microregional oxygen supply/consumption balance after cerebral ischemia-reperfusion. Brain Res. 2018 1683:48-54. PMID 29371097
Moloughney, J.G.*, Kim, P.K.*, Vega-Cotto, N.M.*, Wu, C., Zhang, S., Adlam, M., Lynch, T., Chou, P.C., Rabinowitz, J.D., Werlen, G. and Jacinto, E. mTORC2 responds to glutamine catabolite levels to modulate the hexosamine biosynthesis enzyme GFAT1. Molecular Cell 2016, 63, 811-826. PMID:27570073
Chi, O.Z., Barsoum, S., Vega-Cotto, N.M., Jacinto, E., Liu X., Mellender, S.J., and Weiss, H.R. Effects of rapamycin on cerebral oxygen supply and consumption during reperfusion after cerebral ischemia, Neuroscience 2016 316:321-7. PMID 26742793
Tobias, I., Kaulich, M., Kim, P.K., Simon, N., Jacinto, E., Dowdy, S., King, C.C., and Newton, AC. Protein kinase C z exhibits constitutive phosphorylation and phosphatidylinositol-3,4,5-triphosphate-independent regulation, Biochem J 2016, 473(4):509-23. PMID: 26635352
Lynch, T., Moloughney, J., and Jacinto, E. The mTOR complexes in cancer cell metabolism., in PI3K-mTOR in cancer and cancer therapy 2016, Springer, p. 29-63, ed. B. Leyland Jones, P. De, N. Dey,.
Jacinto, E. and Werlen, G. mTOR: The mTOR complexes in T cell development and immunity, in Encyclopedia of Inflammatory Diseases 2015, ed. M.J. Parnham, Springer.
Chi, O.Z., Wu, C.C., Liu, X., Rah, K.H., Jacinto, E., and Weiss, H.R., Restoration of cerebral oxygen consumption with rapamycin treatment in a rat model of autism-tuberous sclerosis, Neuromolecular Medicine 2015, 17(3):305-13. PMID: 26048361
Chou, P.C., Moloughney, J., Oh, W.J., Wu, C.C., Chen, P.H., Ruegg, M., Hall, M.N., Jacinto, E.* and Werlen, G.* mTORC2 modulates alpha/beta T cell receptor processing and surface expression during thymocyte development., J. Immunol. 2014, 193, 1162-1170. PMID: 24981454 *co-corresponding authors
DeStefano, M.A. and Jacinto, E. Regulation of insulin receptor substrate-1 by mTORC2. Biochem. Soc. Trans. 2013; 41, 896-901. PMID: 23142081
Kim, S.J*., DeStefano, M.A.*, Oh, W.J., Wu, C., Vega-Cotto, N.M., Finlan, M., Liu, D., Su, B., and Jacinto, E. mTOR complex 2 regulates proper turnover of insulin receptor substrate-1 via the ubiquitin ligase Fbw8. Molecular Cell 2012; 48, 875-887. PMID: 23142081
Wu, C., Chou, P., and Jacinto, E. The target of rapamycin; structure and functions, in Protein Kinases 2012, Intech Publishing, p1-40, ed. Xavier, G.
Su, B., and Jacinto, E. mTOR signaling to the AGC kinases. Crit. Rev. in Biochem. and Molec. Biol. 2011, 46, 527-547.
Jacinto, E. TFEBulous control of traffic by mTOR. EMBO J. 2011, 30, 3215-3216
Oh, W., and Jacinto, E. mTOR complex 2 signaling and functions. Cell Cycle 2011; 10, 1-12. PMID: 21670596
Oh, W*., Wu, C.*, Kim, S.J., Facchinetti, V., Julien, L.A., Finlan, M., Roux, P.P., Su, B., and Jacinto, E. mTORC2 associates with ribosomes to promote cotranslational phosphorylation and stability of nascent Akt polypeptide. EMBO J. 2010; 29, 3939-3951. PMID: 21045808
Jacinto, E. AGC kinases in mTOR signaling. Ed. M. Hall and F. Tamanoi: The Enzymes 2010; 27, 101-128. Burlington: Academic Press. PMID: 18215152
Facchinetti, V., Ouyang, W., Wei, H., Soto, N., Lazorchak, A., Gould, C., Lowry, C., Newton, A.C., Mao, Y., Miao, R.Q., Sessa, W.C., Qin, J., Zhang, P., Su, B., and Jacinto, E. The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C. EMBO J 2008; 27, 1932-1943. PMID: 18566586
Jacinto, E., and Lorberg, A. TOR regulation of AGC kinases in yeast and mammals. Biochem. J. 2008; 410, 19-37. PMID:18215152
Jacinto, E. What controls TOR? IUBMB Life 2008; 60, 483-96. PMID: 18493947
Jacinto, E. *, Facchinetti*, V., Liu, D., Soto, N., Wei, S., Jung, S.Y., Huang, Q., Qin, J., and Su, B. SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity. Cell 2006; 127, 125-137. PMID: 16962653
Jacinto, E. Phosphatase targets in TOR signaling. Ed. G. Moorhead, Methods Mol. Biol 2006; 365, 323-334. Humana Press Inc., Totowa, NJ. PMID: 17200572
Jacinto, E.*, Loewith, R.*, Schmidt, A., Lin, S., Ruegg, M., Hall, A., and Hall, M.N. Mammalian TOR complex 2 (mTORC2) controls the actin cytoskeleton and is rapamycin insensitive. Nature Cell Biology 2004; 6, 1122-1128. PMID: 15467718 *equal contribution
Jacinto, E., and Hall, M.N. TOR signaling in bugs, brain, and brawn. Nature Reviews (Mol. Cell. Biol.) 2003; 4, 117-126. PMID: 12563289
Bonenfant, D., Schmelzle, T., Jacinto, E., Crespo, J.L., Mini, T., Hall, M.N., and Jenoe, P. Quantitation of changes in site specific phosphorylation: a simple method based on stable isotope labelling and mass spectrometry. Proc. Natl. Acad. Sci. 2003; 100, 880-885. PMID: 12540831
Loewith, R., Jacinto, E., Wullschleger, S., Lorberg, A., Crespo, J.L., Bonenfant, D., Oppliger, W., Jenoe, P., and Hall, M.N. Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control. Molecular Cell 2002; 10, 457-468. PMID:12408816
Jacinto, E., Guo, B., Arndt, K.T., Schmelzle, T., and Hall, M.N. TIP41 interacts with TAP42 and negatively regulates the TOR signaling pathway. Molecular Cell 2001; 8, 1017-1026. PMID: 11741537
Werlen, G., Jacinto, E., Xia, Y., and Karin, M. Calcineurin preferentially synergizes with PKC-theta to activate JNK in T lymphocytes. EMBO J 1998; 17, 3101-3111. PMID: 9606192
Jacinto, E., Werlen, G., and Karin, M. Cooperation between Syk and Rac1 leads to synergistic JNK activation in T lymphocytes. Immunity 1998; 8, 31-41. PMID: 9462509
Wu, Z., Wu, J., Jacinto, E., and Karin, M. Molecular cloning and characterization of human JNKK2, a novel Jun N-terminal kinase (JNK)-specific kinase. Mol. Cell. Biol 1997; 17, 7407-7416. PMID: 9372971
Su, B., Jacinto, E., Hibi, M., Kallunki, T., Karin, M., and Ben-Neriah, Y. JNK is involved in signal integration during costimulation of T lymphocytes. Cell 1994; 77, 727-736. PMID: 8205621
Jacinto, E. Signal integration in T lymphocytes: The role of JNK and ERK. Dissertation (UCSD) 1997