About this lab:
The Dominguez-Bello laboratory is in the Department of Biochemistry and Microbiology in the School of Environmental and Biological Sciences. Research in the lab focuses on the co-evolution of the microbiota and host, and impacts exerted by Western lifestyle practices. We perform comparative microbial surveys of vertebrate colonized organs, and currently study the human microbiota spanning Westernization. We focus on its development from birth, immune and metabolic functions, impact by modern practices and restoration strategies. We also study the role of the built environment in microbial transmission, integrating the fields of anthropology and architecture into microbial ecology.
- Effects of early life stressors on development
The major goal of this study is to determine perinatal microbial factors that protect against or predispose to metabolic diseases and to type 1 diabetes. JDRF; Emch Fund; C&D Fund, CIFAR, SEBS-IFNH-Seed grant.
- Consequences of lack of direct breastfeeding on the infant microbiome
The major goal of this study is to determine wether bottle-feeding maternal breastmilk introduces developmental changes in the microbiome of babies. Funds: Emch Fund; C&D Fund, CIFAR.
- The microbiome of isolated peoples
Hunter-gatherer societies bring a unique opportunity as a proximities to pre-urban life practices (void of antimicrobial factors such as antibiotics, C-sections, excessive hygiene). This project studies the community structure and function of the bacterial populations in the body of traditional peoples, to understand their protective effect against modern immune and metabolic diseases. Funds: Emch Fund; C&D Fund.