Dr. Hofmann is recognized for her work on coupled physical-biological models. Her research interests are in the areas of physical-biological interactions in marine ecosystems, environmental control and transmission of marine diseases, descriptive physical oceanography, and mathematical modeling of marine ecosystems. She has worked in a variety of marine environments, most recently the continental shelf region of the Ross Sea and the western Antarctic Peninsula, Chesapeake Bay and Delaware Bay, and the Middle Atlantic Bight off the east coast of the United States. Her contributions to modeling physical-biological interactions in marine systems were recognized by her election as a 2013 Fellow of the American Geophysical Union.