LAB’S MISSION AND GOAL:
The long-term goal of The Anthony Lab is to identify dietary components and cellular processes that prevent and treat serious diseases and promote healthspan. We aim to achieve this goal by identifying mechanisms of proteostasis control in organ systems throughout the body. We are especially interested in understanding how altering the supply of amino acids, in total or individually, is sensed and communicated under different metabolic states. We also are interested in metabolic and molecular responses to exercise and the crosstalk between diet, physical activity, and biological rhythms.
Research OVERVIEW
Our Big Question: How does the body sense nutrients and turn that information into decisions about growth, stress resistance, and survival?
The Anthony Lab studies how amino acids and other nutrients are detected at the cellular level, how this activates the Integrated Stress Response (ISR) and other related signaling pathways, and how those signals ripple out to affect metabolism, organ and tissue function, disease progression, and whole-body health.
We use a mix of mouse models, cell culture, omics (transcriptomics, proteomics, metabolomics), metabolic phenotyping, and computational modeling. We study nutrition at the molecular level all the way to the whole organism. Lab projects give trainees a strong conceptual grounding in how cells survive and adapt to stress.