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The Anthony Lab studies homeostatic responses to changes in nutrient supply and environmental stress. Our experiments aim to identify dietary components and cellular processes that prevent and treat serious diseases and promote healthspan. Over the years my group has published numerous high impact publications which delineate mechanisms of metabolic and proteostasis control by diet, drugs, genetics and environmental stressors. These works have spanned many organ systems including endocrine, gastrointestinal, hepatobiliary, immune, lymphatic, muscular and the central nervous system. With respect to diet and nutrient supply, we study how amino acid insufficiency or imbalance alters tissue proteostasis in the whole animal. We use experimental models that alter amino acid availability and work to understand how altering the supply of amino acids, in total or individually, is sensed and communicated under different metabolic states. We also are interested in metabolic and molecular responses to exercise and the crosstalk between diet and physical activity. Current projects in the laboratory may be grouped into the following areas: