Cell-Extracellular Matrix Interactions Play Multiple Essential Roles in Aortic Arch Development
Pharyngeal arch artery formation is a multistep process entailing the dynamic contribution of SHF-derived ECs to pharyngeal arches, the remodeling of endothelial plexus into the PAAs, and the remodeling of the PAAs into the aortic arch artery and its major branches. Cell-ECM interactions regulated by integrin α5β1 and Fn1 play essential roles at each of these developmental stages. See article by Warkala et al DOI: 10.1161/CIRCRESAHA.120.318200 See editorial by Robert Kelly DOI: 10.1161/CIRCRESAHA.121.318669