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Publications

https://www.ncbi.nlm.nih.gov/myncbi/sophie.astrof.2/bibliography/public/

2023 –

Alexander BE, Zhao H, and Astrof S. SMAD4: A critical regulator of cardiac neural crest cell fate and vascular smooth muscle development. Dev. Dyn. 2023 Aug 31, doi: 10.1002/dvdy.652

Astrof S, Arriagada C, Saijoh Y, Francou A, Kelly RG, Moon A. Aberrant differentiation of second heart field mesoderm prefigures cellular defects in the outflow tract in response to loss of FGF8. Dev Biol 499:10-21, 2023

Melamed S, Zaffryar-Eilot S, Nadjar-Boger E, Aviram R, Zhao H, Yaseen-Badarne W, Kalev-Altman R, Sela-Donenfeld D, Lewinson O, Astrof S, Hasson P, Wolfenson H. Initiation of fibronectin fibrillogenesis is an enzyme-dependent process. Cell Rep. 2023 May 4;42(5):112473. doi: 10.1016/j.celrep.2023.112473. PMID: 37148241

Ramirez A, Degenhardt K, and Astrof S. Identification of novel buffering mechanisms in aortic arch artery development and congenital heart disease. BioRxiv 2023 doi: https://doi.org/10.1101/2023.03.02.530833

 

2020 – 2022

Arriagada C and Astrof S. The mesodermal source of fibronectin is required for heart morphogenesis and cardiac outflow tract elongation by regulating cell shape, polarity, and mechanotransduction in the second heart field. BioRxiv 2022 DOI: doi.org/10.1101/2022.10.28.514299

Tomer D, Arriagada C, Munshi S, Alexander BE, French B, Vedula P, Caorsi V, House A, Guvendiren M, Kashina A, Schwarzbauer JE, Astrof S. A new mechanism of fibronectin fibril assembly revealed by live imaging and super-resolution microscopy. Journal of Cell Science (2022) 135, jcs260120. DOI: 10.1242/jcs.260120.   See also: Research Highlight and First author interview

Metikala S, Warkala M, Casie Chetty S, Chestnut B, Rufin Florat D, Plender E, Nester O, Koenig AL, Astrof S, Sumanas S. Integration of vascular progenitors into functional blood vessels represents a distinct mechanism of vascular growth. Dev Cell. 2022 Mar 28;57(6):767-782.e6. DOI: 10.1016/j.devcel.2022.02.015. Epub 2022 Mar 10.PMID: 35276066

Warkala M, Chen D, Ramirez A, Jubran A, Schonning MJ, Wang X, Zhao H, Astrof S. Cell-Extracellular Matrix Interactions Play Multiple Essential Roles in Aortic Arch Development. Circulation Research Volume 128, Issue 3, 5 February 2021; Pages e27-e44
https://doi.org/10.1161/CIRCRESAHA.120.318200. See also: Commentary and Meet the first author

Ramirez A, Astrof S. Visualization and Analysis of Pharyngeal Arch Arteries using Whole-mount Immunohistochemistry and 3D Reconstruction. J Vis Exp. 2020 Mar 31;(157). doi: 10.3791/60797. PubMed PMID: 32310236; PubMed Central PMCID: PMC7216781.

 

 

2010 – 2019

Choi S, Pfleger J, Jeon YH, Yang Z, He M, Shin H, Sayed D, Astrof S, Abdellatif M. Oxoglutarate dehydrogenase and acetyl-CoA acyltransferase 2 selectively associate with H2A.Z-occupied promoters and are required for histone modifications.Biochim Biophys Acta Gene Regul Mech. 2019 Oct;1862(10):194436. doi: 10.1016/j.bbagrm.2019.194436. Epub 2019 Nov 1.PMID: 31682939

Wang X, Astrof S. Isolation of Mouse Cardiac Neural Crest Cells and Their Differentiation into Smooth Muscle Cells. Bio Protoc. 2017 Sep 5;7(17). doi: 10.21769/BioProtoc.2530. PubMed PMID: 28979923; PubMed Central PMCID: PMC5624110.

Wang X, Chen D, Chen K, Jubran A, Ramirez A, Astrof S. Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field. Dev Biol. 2017 Jan 15;421(2):108-117. doi: 10.1016/j.ydbio.2016.12.010. Epub 2016 Dec 9. PubMed PMID: 27955943; PubMed Central PMCID: PMC5221477.

Wang X, Astrof S. Neural crest cell-autonomous roles of fibronectin in cardiovascular development. Development. 2016 Jan 1;143(1):88-100. doi: 10.1242/dev.125286. Epub 2015 Nov 9. PubMed PMID: 26552887; PubMed Central PMCID: PMC4725203.

Chen D, Wang X, Liang D, Gordon J, Mittal A, Manley N, Degenhardt K, Astrof S. Fibronectin signals through integrin α5β1 to regulate cardiovascular development in a cell type-specific manner. Dev Biol. 2015 Nov 15;407(2):195-210. doi: 10.1016/j.ydbio.2015.09.016. Epub 2015 Oct 3. PubMed PMID: 26434918; PubMed Central PMCID: PMC5312697.

Liang D, Wang X, Mittal A, Dhiman S, Hou SY, Degenhardt K, Astrof S. Mesodermal expression of integrin α5β1 regulates neural crest development and cardiovascular morphogenesis. Dev Biol. 2014 Nov 15;395(2):232-44. doi: 10.1016/j.ydbio.2014.09.014. Epub 2014 Sep 19. PubMed PMID: 25242040; PubMed Central PMCID: PMC4252364.

Pulina M, Liang D, Astrof S. Shape and position of the node and notochord along the bilateral plane of symmetry are regulated by cell-extracellular matrix interactions. Biol Open. 2014 Jun 13;3(7):583-90. doi: 10.1242/bio.20148243. PubMed PMID: 24928429; PubMed Central PMCID: PMC4154294.

Villegas SN, Rothová M, Barrios-Llerena ME, Pulina M, Hadjantonakis AK, Le Bihan T, Astrof S, Brickman JM. PI3K/Akt1 signalling specifies foregut precursors by generating regionalized extra-cellular matrix. Elife. 2013 Dec 24;2:e00806. doi: 10.7554/eLife.00806. PubMed PMID: 24368729; PubMed Central PMCID: PMC3871052.

Mittal A, Pulina M, Hou SY, Astrof S. Fibronectin and integrin alpha 5 play requisite roles in cardiac morphogenesis. Dev Biol. 2013 Sep 1;381(1):73-82. doi: 10.1016/j.ydbio.2013.06.010. Epub 2013 Jun 17. PubMed PMID: 23791818; PubMed Central PMCID: PMC3833817.

Pulina MV, Hou SY, Mittal A, Julich D, Whittaker CA, Holley SA, Hynes RO, Astrof S. Essential roles of fibronectin in the development of the left-right embryonic body plan. Dev Biol. 2011 Jun 15;354(2):208-20. doi: 10.1016/j.ydbio.2011.03.026. Epub 2011 Apr 3. PubMed PMID: 21466802; PubMed Central PMCID: PMC3225965.

Mittal A, Pulina M, Hou SY, Astrof S. Fibronectin and integrin alpha 5 play essential roles in the development of the cardiac neural crest. Mech Dev. 2010 Sep-Dec;127(9-12):472-84. doi: 10.1016/j.mod.2010.08.005. Epub 2010 Aug 31. PubMed PMID: 20807571; PubMed Central PMCID: PMC3233353.

 

2004 – 2009

Astrof S, Hynes RO. Fibronectins in vascular morphogenesis. Angiogenesis. 2009;12(2):165-75. doi: 10.1007/s10456-009-9136-6. Epub 2009 Feb 14. Review. PubMed PMID: 19219555; PubMed Central PMCID: PMC2716138.

Stern P, Astrof S, Erkeland SJ, Schustak J, Sharp PA, Hynes RO. A system for Cre-regulated RNA interference in vivo. Proc Natl Acad Sci U S A. 2008 Sep 16;105(37):13895-900. doi: 10.1073/pnas.0806907105. Epub 2008 Sep 8. PubMed PMID: 18779577; PubMed Central PMCID: PMC2532697.

Astrof S, Crowley D, Hynes RO. Multiple cardiovascular defects caused by the absence of alternatively spliced segments of fibronectin. Dev Biol. 2007 Nov 1;311(1):11-24. doi: 10.1016/j.ydbio.2007.07.005. Epub 2007 Jul 12. PubMed PMID: 17706958; PubMed Central PMCID: PMC2080666.

Astrof S, Kirby A, Lindblad-Toh K, Daly M, Hynes RO. Heart development in fibronectin-null mice is governed by a genetic modifier on chromosome four. Mech Dev. 2007 Aug;124(7-8):551-8. doi: 10.1016/j.mod.2007.05.004. Epub 2007 Jun 2. PubMed PMID: 17628448.

Matuskova J, Chauhan AK, Cambien B, Astrof S, Dole VS, Piffath CL, Hynes RO, Wagner DD. Decreased plasma fibronectin leads to delayed thrombus growth in injured arterioles. Arterioscler Thromb Vasc Biol. 2006 Jun;26(6):1391-6. doi: 10.1161/01.ATV.0000216282.58291.c6. Epub 2006 Mar 9. PubMed PMID: 16528004.

Astrof S, Crowley D, George EL, Fukuda T, Sekiguchi K, Hanahan D, Hynes RO. Direct test of potential roles of EIIIA and EIIIB alternatively spliced segments of fibronectin in physiological and tumor angiogenesis. Mol Cell Biol. 2004 Oct;24(19):8662-70. doi: 10.1128/MCB.24.19.8662-8670.2004. PubMed PMID: 15367684; PubMed Central PMCID: PMC516752.

 

1998 – 2002

Snitkovsky S, Young JA. Targeting retroviral vector infection to cells that express heregulin receptors using a TVA-heregulin bridge protein. Virology. 2002 Jan 5;292(1):150-5. doi: 10.1006/viro.2001.1314. PubMed PMID: 11878917.

Snitkovsky S, Niederman TM, Mulligan RC, Young JA. Targeting avian leukosis virus subgroup A vectors by using a TVA-VEGF bridge protein. J Virol. 2001 Feb;75(3):1571-5. doi: 10.1128/JVI.75.3.1571-1575.2001. PubMed PMID: 11152532; PubMed Central PMCID: PMC114065.

Snitkovsky S, Niederman TM, Carter BS, Mulligan RC, Young JA. A TVA-single-chain antibody fusion protein mediates specific targeting of a subgroup A avian leukosis virus vector to cells expressing a tumor-specific form of epidermal growth factor receptor. J Virol. 2000 Oct;74(20):9540-5. doi: 10.1128/jvi.74.20.9540-9545.2000. PubMed PMID: 11000224; PubMed Central PMCID: PMC112384.

Boerger AL, Snitkovsky S, Young JA. Retroviral vectors preloaded with a viral receptor-ligand bridge protein are targeted to specific cell types. Proc Natl Acad Sci U S A. 1999 Aug 17;96(17):9867-72. doi: 10.1073/pnas.96.17.9867. PubMed PMID: 10449786; PubMed Central PMCID: PMC22302.

Snitkovsky S, Young JA. Cell-specific viral targeting mediated by a soluble retroviral receptor-ligand fusion protein. Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):7063-8. doi: 10.1073/pnas.95.12.7063. PubMed PMID: 9618539; PubMed Central PMCID: PMC22739.

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