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Publications

  1. Francisco J, and Del Re DP*. Inflammation in myocardial ischemia/reperfusion injury: underlying mechanisms and therapeutic potential. Antioxidants. 2023; 12(11): 1944. *Corresponding author.
  2. Nakamura M, Keller MA, Fefelova N, Zhai P, Liu T, Tian Y, Ikeda S, Del Re DP, Li H, Xie LH, and Sadoshima J. Ser14 phosphorylation of Bcl-xL mediates compensatory cardiac hypertrophy in male mice. Nat. Commun. 2023; 14(1): 5805.
  3. Francisco J, Guan J, Zhang Y, Nakada Y, Mareedu S, Sung E, Hu CM, Oka S, Zhai P, Sadoshima J, and Del Re DP*. Suppression of myeloid YAP antagonizes adverse cardiac remodeling during pressure overload stress. J. Mol. Cell. Cardiol. 2023; 181: 1-14. *Corresponding author.
  4. Del Re DP* and Liu Q*. ITCH puts the brakes on septic cardiomyopathy. J. Mol. Cell. Cardiol. Plus. 2022; 2. *Co-Corresponding author.
  5. Francisco J and Del Re DP*. YAP/TAZ dull the STING of aging. J. Cardiovasc. Aging. 2022; 2(4). *Corresponding author.
  6. Del Re DP*. Hippo-Yap signaling in cardiac and fibrotic remodeling. Curr. Opin. Physiol. 2022; 26. *Corresponding author.
  7. Del Re DP*. Mechanisms of ischemic heart injury. Cells. 2022;11(9): 1384. *Corresponding author.
  8. Lindsey ML, Brunt KR, Kirk JA, Kleinbongard P, Calvert JW, de Castro Bras LE, DeLeon-Pennell KY, Del Re DP, Frangogiannis NG, Frantz S, Gumina RJ, Halade GV, Jones SP, Ritchie RH, Spinale FG, Thorp EB, Ripplinger CM, and Kassiri Z. Guidelines for in vivo mouse models of myocardial infarction. Am. J. Physiol. Heart Circ. Physiol. 2021; 321(6): H1056-H1073.
  9. Shao D, Zhai P, Hu C, Mukai R, Sciarretta S, Del Re DP, and Sadoshima J. Lats2 promotes heart failure by stimulating p53-mediated apoptosis during pressure overload. Sci. Rep. 2021; 11(1):23469.
  10. Francisco J, Zhang Y, Nakada Y, Jeong JI, Huang CY, Ivessa A, Oka S, Babu G and Del Re DP*. AAV-mediated YAP expression in cardiac fibroblasts promotes inflammation and increases fibrosis. Sci. Rep. 2021; 11(1): 10553. *Corresponding author.
  11. Francisco J, Zhang Y, Jeong JI, Mizushima W, Ikeda S, Ivessa A, Oka S, Zhai P, Tallquist M and Del Re DP*. Blockade of fibroblast YAP attenuates cardiac fibrosis and dysfunction through MRTF-A inhibition. JACC Basic Transl. Sci. 2020; 5(9): 931-945. *Corresponding author.
  12. Francisco J, Byun, J, Zhang Y, Berman O, Mizushima W, Oka S, Zhai P, Sadoshima J and Del Re DP*. The tumor suppressor RASSF1A modulates inflammation and injury in the reperfused myocardium. J. Biol. Chem. 2019; 294(35): 13131-13144. *Corresponding author.
  13. Del Re DP, Amgalan D, Linkermann A, Liu Q and Kitsis RN. Fundamental mechanisms of regulated cell death and implications for heart disease. Physiol. Rev. 2019; 99(4): 1765-1817.
  14. Ikeda S, Mukai R, Mizushima W, Zhai P, Oka S, Nakamura M, Del Re DP, Sciarretta S, Hsu CP, Shimokawa H and Sadoshima J. Yes-associated protein (YAP) facilitates pressure-overload induced dysfunction in the diabetic heart. JACC Basic Transl. Sci. 2019; 4(5):611-622.
  15. Hitscherich P, Xie L-H, Del Re DP and Lee EJ. The effects of macrophages on cardiomyocyte calcium-handling function using in vitro culture models. Physiol. Rep. 2019; 7(13): e14137.
  16. Byun J*, Del Re DP*, Zhai P, Ikeda S, Shirakabe A, Mizushima W, Miyamoto S, Brown JH and Sadoshima J. Yes-associated protein (YAP) mediates adaptive cardiac hypertrophy in response to pressure overload. J. Biol. Chem. 2019; 294(10): 3603-3617. *Equal contribution.
  17. Ikeda S, Mizushima W, Sciarretta S, Abdellatif M, Zhai P, Mukai R, Fefelova N, Oka SI, Nakamura M, DelRe DP, Farrance IK, Park JY, Tian B, Xie LH, Kumar M, Hsu CP, Sadayappan S, Shimokawa H, Lim DS and Sadoshima J. Hippo deficiency leads to cardiac dysfunction accompanied by cardiomyocyte de-differentiation during pressure overload. Circ. Res. 2019; 124(2): 292-305.
  18. Del Re DP*. Beyond the cardiomyocyte: consideration of Hippo pathway cell type-specificity. Circ. Res. 2018; 123(1): 30-32. *Corresponding author.
  19. Sciarretta S, Yee D, Nagarajan N, Bianchi F, Saito T, Valenti V, Tong M, Del Re DP, Vecchione C, Shirone L, Forte M, Rubattu S, Shirakabe A, Boppana VS, Volpe M, Frati G, Zhai P and Sadoshima J. Trehalose-induced activation of autophagy improves cardiac remodeling after myocardial infarction. J. Am. Coll. Cardiol. 2018; 71(18):1999-2010.
  20. Chang C, Zhao Q, Gonzalez JP, Kim JH, Alzahrani, Del Re DP and Fraidenraich D. Hematopoietic Id deletion triggers endomyocardial fibrotic and vascular defects in the adult heart. Sci. Rep. 2017; 7(1):3079.
  21. Zhang Y and Del Re DP*. A growing role for the Hippo signaling pathway in the heart. J. Mol. Med. 2017; 95(5):465-472. *Corresponding author.
  22. Matsuda T, Jeong JI, Ikeda S, Yamamoto T, Gao S, Babu GJ, Zhai P and Del Re DP*. H-Ras isoform mediates protection against pressure overload-induced cardiac dysfunction in part through activation of Akt. Circ. Heart Fail. 2017; 10(2). *Corresponding author.
  23. Matsuda T, Zhai P, Sciarretta S, Zhang Y, Jeong JI, Ikeda S, Park JY, Hsu CP, Tian B, Pan D, Sadoshima J and Del Re DP*. NF2 activates Hippo signaling and promotes ischemia/reperfusion injury in the heart. Circ. Res. 2016; 119(5):596-606. *Corresponding author.
  24. Nakamura M, Zhai P, Del Re DP, Maejima Y and Sadoshima J. Mst1-mediated phosphorylation of Bcl-xL is required for myocardial reperfusion injury. JCI Insight; 1(5), 2016.
  25. Del Re DP*. Hippo signaling in the heart: Non-canonical pathways impact growth, survival and function. Circ. J. 2016; 80(7):1504-10. *Corresponding author.
  26. Klionsky DJ et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy 2016; 12(1):1-222.
  27. Yang Y*, Del Re DP*, Nakano N, Sciarretta S, Zhai P, Park JY, Sayed D, Matsushima S, Park Y, Tian B, Abdellatif M and Sadoshima J. miR-206 mediates YAP-induced cardiac hypertrophy and survival. Circ. Res. 2015; 117(10): 891-904. *Equal contribution.
  28. Sciarretta S, Zhai P, Maejima Y, Del Re DP, Nagarajan N, Yee D, Liu T, Magnuson MA, Volpe V, Frati G, Li H and Sadoshima J. mTORC2 regulates cardiac response to stress by inhibiting MST1. Cell Reports 2015; 11(1):125-36.
  29. Wackerhage H, Del Re DP, Judson RN, Sudol M and Sadoshima J. The Hippo signal transduction network in skeletal and cardiac muscle. Sci. Signal. 2014; 7(337).
  30. Del Re DP. The Hippo signaling pathway: implications for heart regeneration and disease. Clin. Transl. Med. 2014; 3:27.
  31. Del Re DP, Matsuda T, Zhai P, Maejima Y, Jain MR, Liu T, Li H, Hsu CP, and Sadoshima J. Mst1 promotes cardiac myocyte apoptosis through phosphorylation and inhibition of Bcl-xL. Mol. Cell 2014; 54(4): 639-50.
  32. Del Re DP and Sadoshima J. Elucidating ERK2 function in the heart. J. Mol. Cell. Cardiol. 2014; 72: 336-8.
  33. Shao D, Zhai P, Del Re DP, Sciarretta S, Yabuta N, Nojima H, Lim DS, Pan D and Sadoshima J. A functional interaction between Hippo-YAP signalling and FoxO1 mediates the oxidative stress response. Nat. Commun. 2014; 5:3315.
  34. Maejima Y, Kyoi S, Zhai P, Liu T, Li H, Ivessa A, Sciarretta S, Del Re DP, Zablocki DK, Hsu CP, Lim DS, Isobe M, and Sadoshima J. Mst1 inhibits autophagy by promoting the interaction between Beclin1 and Bcl-2. Nat. Med. 2013; 19(11):1478-88.
  35. Del Re DP, Yang Y, Nakano N, Cho J, Zhai P, Yamamoto T, Zhang N, Yabuta N, Nojima H, Pan D and Sadoshima J. Yes-associated protein isoform 1 (Yap1) promotes cardiomyocyte survival and growth to protect against myocardial ischemic injury. J. Biol. Chem.2013; 288(6):3977-88.
  36. Del Re DP and Sadoshima J. RASSF1A signaling in the heart: Novel functions beyond tumor suppression. Mol. Biol. Int. 2012; 2012:154283.
  37. Del Re DP and Sadoshima J. Enhancing the potential of cardiac progenitor cells: pushing forward with Pim-1. Circ. Res. 2012; 110(9):1154-6.
  38. Xiang SY, Vanhoutte D, Del Re DP, Purcell NH, Ling H, Banerjee I, Bossuyt J, Lang RA, Zheng Y, Matkovich SJ, Miyamoto S, Molkentin JD, Dorn GW and Brown JH. RhoA protects the mouse heart against ischemia/reperfusion injury. J. Clin. Invest. 2011; 121(8): 3269-76.
  39. Del Re DP and Sadoshima J. Is Raf1 a nexus for cardiac hypertrophic signaling in human disease?  J. Mol. Cell. Cardiol. 2011; 51(1):1-3.
  40. Zhao Q, Beck AJ, Vitale JM, Schneider JS, Chang C, Gao S, Del Re DP, Bhaumik M, Yehia G, Sadoshima J, and Fraidenraich D. Injection of wild-type embryonic stem cells into Mst1 transgenic blastocysts prevents adult-onset cardiomyopathy. Stem Cell Rev. 2011; 7(2):326-30.
  41. Del Re DP, Matsuda T, Zhai P, Gao S, Clark GJ, Van Der Weyden L, and Sadoshima J. Proapoptotic Rassf1A/Mst1 signaling in cardiac fibroblasts is protective against pressure overload in mice. J. Clin. Invest. 2010; 120(10): 3555-67.
  42. Miyamoto S*, Del Re DP*, Xiang SY, Zhao X, Florholmen G, and Brown JH. Revisited and Revised: Is RhoA always a villain in cardiac pathophysiology?  J. Cardiovasc. Transl. Res. 2010; 3(4): 330-43. *Equal contribution.
  43. Del Re DP and Sadoshima J. Optimizing cell-based therapy for cardiac regeneration.  Circulation 2009; 120(10):831-4.
  44. Del Re DP, Miyamoto S, and Brown JH. FAK as a RhoA-activable signaling scaffold mediating Akt activation and cardiomyocyte protection.  J. Biol. Chem. 2008; 283(51):35622-9.
  45. Del Re DP, Miyamoto S, and Brown JH. RhoA /Rho kinase upregulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis.  J. Biol. Chem. 2007; 282(11):8069-78.
  46. Brown JH, Del Re DP, and Sussman MA. The Rac and Rho Hall of Fame: A Decade of Hypertrophic Signaling Hits.  Circ. Res. 2006; 98(6):730-42.