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Publications

  1. Nassar R, Brini E, Parui S, Liu C, Dignon GL, Dill KA, ”Accelerating protein molecular dynamics with machine learning”, Journal of Chemical Theory and Computation, 18, 1929-1935 (2022).
  2. Nassar R*, Dignon GL*, Razban RM*, Dill KA, “The protein folding problem: The role of theory”, Journal of Molecular Biology, 433, 167126 (2021).
  3. Perdikari TM, Jovic N, Dignon GL, Kim YC, Fawzi NL, Mittal J, “A predictive coarsegrained model for position-specific effects of post-translational modifications”, Biophysical Journal, 120, 1187-1197 (2021).
  4. Ryan VH, Perdikari TM, Naik MT, Saueressig CF, Lins J, Dignon GL, Mittal J, Hart AC, Fawzi NL, “Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning & reduces neurodegeneration”, EMBO Journal, 40, e105001 (2021).
  5. Zheng W*, Dignon GL*, Xu X, Regy RM, Best RB, Zheng W, Mittal J, “Molecular details of protein condensates probed by microsecond-long atomistic simulations”, Journal of Physical Chemistry B, 124, 11671-11679 (2020).
  6. Regy RM, Dignon GL, Zheng W, Kim YC, Mittal J, “Sequence dependent phase separation of protein-polynucleotide mixtures elucidated using molecular simulations”, Nucleic Acids Research, 48, 12593-12603 (2020).
  7. Schuster BS*, Dignon GL*, Jahnke CN, Simpkins AG, Hammer DA, Good MC, Mittal J, “Identifying Sequence Perturbations to an Intrinsically Disordered Protein that Determine its Phase Separation Behavior”, Proceedings of the National Academy of Sciences, 117, 11421-11431 (2020).
  8. Zheng W, Dignon GL, Brown M, Kim YC, Mittal J, “Hydropathy patterning complements charge patterning to describe conformational preferences of disordered proteins”, Journal of Physical Chemistry Letters, 11, 3408-3415 (2020).
  9. Dignon GL, Best, RB, Mittal J, “Biomolecular Phase Separation: From Molecular Driving Forces to Macroscopic Properties”, Annual Review of Physical Chemistry, 71, 53-75, (2020).
  10. Conicella AE*, Dignon GL*, Schmidt HB, Zerze GH, D’Ordine AM, Kim YC, Rohatgi R,Ayala YM, Mittal J, Fawzi NL, “TDP-43  -helical structure tunes liquid-liquid phase separation and function”, Proceeding of the National Academy of Sciences, 117, 5883-5894 (2020).
  11. Murthy A, Dignon GL, Kan Y, Zerze GH, Parekh S, Mittal J, Fawzi NL, “Molecular interactions underlying liquid phase separation of the FUS low-complexity domain”, Nature Structural and Molecular Biology, 26, 637-648 (2019).
  12. Dignon GL*, Zheng W*, Kim YC, Mittal J, “Temperature controlled liquid-liquid phase separation of disordered proteins”, ACS Central Science, 5, 821-830 (2019).
  13. Dignon GL, Zheng W, Mittal J, “Simulation methods for liquid-liquid phase separation of disordered proteins”, Current Opinion in Chemical Engineering, 23, 92-98 (2019).
  14. Dignon GL*, Zheng W*, Best RB, Kim YC, Mittal J, “Relation between single-molecule properties and phase behavior of intrinsically disordered proteins”, Proceedings of the National Academy of Sciences, 115, 9929-9934 (2018).
  15. Ryan VH, Dignon GL, Zerze GH, Chabata CV, Silva R, Conicella AE, Amaya J, Burke KA, Mittal J, Fawzi NL, “Mechanistic View of hnRNPA2 Low-Complexity Domain Structure, Interactions, and Phase Separation Altered by Mutation and Arginine Methylation”, Molecular Cell, 69, 465-479 (2018).
  16. Dignon GL*, Zheng W*, Kim YC, Best RB, Mittal J, “Sequence determinants of protein phase behavior from a coarse-grained model”, PLOS Computational Biology, 14, e1005941 (2018).
  17. Dignon GL, Zerze GH, Mittal J, “Interplay Between Membrane Composition and Structural Stability of Membrane-Bound IAPP”, The Journal of Physical Chemistry B, 121, 8661-8668 (2017).
  18. Monahan Z, Ryan VH, Janke AM, Burke KA, Zerze GH, O’Meally R, Dignon GL, Conicella AE, Zheng W, Best RB, Cole RN, Mittal J, Shewmaker F, Fawzi NL, “Phosphorylation of the FUS low-complexity domain disrupts phase separation, aggregation, and toxicity”, The EMBO Journal, 36, 2951-2967, (2017).

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