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Publications in the past 10 years:

Montroull, L.E., D. Rothbard, H.D. Kanal, V. D’Mello, V. Dodson, C.M. Troy, J.P. Zanin, S.W. Levison, and W.J. Friedman, Pro-Neurotrophins induce apoptotic neuronal death after controlled cortical impact injury in adult mice, ASN Neuro, 12:1-13; https://doi.org/10.1177/1759091420930865, 2020

Zanin, J.P.*, L.E. Montroull*, M. Volosin, and W.J. Friedman, p75NTR modulates TrkB trafficking and signaling in response to BDNF treatment in hippocampal neurons, Frontiers in Cellular Neuroscience, https://doi.org/10.3389/fncel.2019.00485, 2019

Zanin, J.P., J. Verpeut, Li, Y., Shiflett, M.W., S.-S. Wang, Santhakumar, V., and W.J. Friedman, The p75NTR influences cerebellar circuit development and adult behavior via regulation of cell cycle duration of granule cell progenitors, J. Neurosci. 39 (46) 9119-9129; DOI: https://doi.org/10.1523/JNEUROSCI.0990-19.2019, 2019, Cover Article

Saadipour, K., A. Tiberi, S. Lomardo, L. Montroull, N. Manucat, J. LaFrancois, M. Cammer, P. Mathews, H. Scharfman, F.-F. Liao, W. Friedman, X.-F. Zhou, G. Tesco, and M. Chao, Regulation of BACE1 expression after injury is linked to the p75 neurotrophin receptor, Molecular and Cellular Neuroscience, 99, https://doi.org/10.1016/j.mcn.2019.103395, 2019

Cragnolini, A.B., G. Montenegro, W.J. Friedman, and D.H. Mascó, Brain-region specific responses of astrocytes to an in vitro injury and neurotrophins, Molecular and Cellular Neuroscience, 88:240-248, doi: 10.1016/j.mcn.2018.02.007, 2018

Greenwood, S.G. L. Montroull, M. Volosin, H. E. Scharfman, K.K.Teng, M. Light, R. Torkin, F. Maxfield, B.L. Hempstead, and W.J. Friedman, A novel neuroprotective mechanism for lithium that prevents association of the p75NTR-sortilin receptor complex and attenuates proNGF-induced neuronal death in vitro and in vivo, eNeuro, 5 (1) DOI: https://doi.org/10.1523/ENEURO.0257-17. 2017

Zanin, J.P., E. Abercrombie, and W.J. Friedman, Proneurotrophin-3 promotes cell cycle withdrawal of developing cerebellar granule cell progenitors via the p75 neurotrophin receptor, eLife, DOI: 10.7554/eLife.16654, 2016

VonDran, M.W., J. LaFrancois, V.A. Padow, W.J. Friedman, H.E. Scharfman, T.A. Milner, B.L. Hempstead, ProBDNF, but not proNGF, is upregulated following seizures in mice, ASN Neuro, Sep 25;6(5): 1759091414552185. doi: 10.1177/1759091414552185, 2014

Friedman, W.J., A.P. Le, S. Choi, and M. Volosin, Seizures tip the balance of neurotrophin signaling towards neuronal death, in Handbook of Neurotoxicology “Physiology and pathophysiology of neurotrophins”, (R.M Kostrzewa, ed.) Springer, pp. 1945-1953, 2014

Choi, S. and W.J. Friedman, Interleukin-1b enhances neuronal vulnerability to proNGF-mediated apoptosis by increasing surface expression of p75NTR and sortilin, Neuroscience, 257:11-19, 2014

Pichardo-Casas, I., L.A. Goff, M.R. Swerdel, A. Athie, J. Davila, M. Ramos-Brossier, M. Lapid-Volosin, W.J. Friedman, R.P. Hart, and L. Vaca, Expression profiling of synaptic microRNAs from the adult rat brain identifies regional differences and seizure-induced regulation, Brain Res. 1436:20-33, 2012

Cragnolini, A, Y. Huang, M. Volosin, and W.J. Friedman, Nerve growth factor induces cell cycle arrest of astrocytes, Dev. Neurobiol, 72 (6):766-776, 2012 (Epub doi: 10.1002/dneu.20981, 2011)

Le, A. and W.J. Friedman, Matrix metalloproteinase-7 regulates cleavage of proNGF and is neuroprotective following kainic acid-induced seizures, J. Neurosci. 32(2):703–712, 2012 (Highlighted in “This week in the Journal”)

Huang, Y., D. E. Smith, O. Ibáñez-Sandoval, J. E. Sims, and W. J. Friedman, Neuron-Specific Effects of Interleukin-1ß are Mediated by a Novel Isoform of the IL-1 Receptor Accessory Protein, J. Neurosci. 31(49):18048 –18059, 2011

Song, W., A Cragnolini, B.L. Hempstead, and W.J. Friedman, ProNGF induces PTEN via p75NTR to suppress Trk-mediated survival signaling in brain neurons, J. Neurosci. 30(46):15608-15, 2010 (Highlighted in “This week in the Journal”)

Friedman, W.J., Proneurotrophins, seizures, and neuronal apoptosis, The Neuroscientist, 16(3):244-52, 2010