Publications
Selected Publications:
- Gonzalez AE, Liu Y, Wang D, Jeziorek M, Bandyopadhyay S, Rao A, Gao N, Etchegaray JP (2023). TET3-mediated DNA oxidation is essential for intestinal epithelial cell response to stressors. Proc Natl Acad Sci U S A. Sept 12, 120(37):e2221405120. PMID: 37669386
- Sherman LS, Patel SA, Castillo MD, Unkovic R, Taborga M, Gergues M, Patterson S, Etchegaray JP, Jaloudi M, Hooda-Nehra A, Kra J, Rojas DP, Chang VT, Rameshwar P (2021). NFkB targeting in bone marrow mesenchymal stem cell-mediated support of age-linked hematological malignancies. Stem Cell Rev Rep. Dec;17(6):2178-2192. PMID: 34410592
- Sorrentino VG, Thota S, Gonzalez EA, Rameshwar P, Chang VT, Etchegaray JP (2021). Hypomethylating Chemotherapeutic Agents as Therapy for Myelodysplastic Syndromes and Prevention of Acute Myeloid Leukemia. Pharmaceuticals (Basel) 14(7):641. PMID: 34358067
- Sinha G, Ferrer AI, Ayer S, El-Far MH, Pamarthi SH, Naaldijk Y, Barak P, Sandiford OA, Bibber BM, Yehia G, Greco SJ, Jiang JG, Bryan M, Kumar R, Ponzio NM, Etchegaray JP, Rameshwar P (2021). Specific N-cadherin dependent pathways drive human breast cancer dormancy in bone marrow. Life Sci Alliance 4(7):e202000969. PMID: 34078741
- Khan D, Ara T, Ravi V, Rajagopal R, Tandon H, Parvathy J, Gonzalez EA, Asirvatham-Jeyaraj N, Krishna S, Mishra S, Raghu S, Bhati AS, Tamta AK, Dasgupta S, Kolthur-Seetharam U, Etchegaray JP, Mostoslavsky R, Rao PSM, Srinivasan N, Sundaresan NR (2021). SIRT6 transcriptionally regulates fatty acid transport by suppressing PPARg. Cell Rep 35(9):109190. PMID: 34077730
- Sandiford O, Donnelly R, El-Far M, Burmeyer L, Sinha G, Pamarthi SH, Sherman L, Ferrer A, DeVore A, Patel S, Naaldijk Y, Alonso S, Barak P, Bryan M, Ponzio N, Narrayanan R, Etchegaray JP, Kumar R, and Rameshwar P (2021). Mesenchymal stem cell secreted extracellular vesicle instructs stepwise dedifferentiation of breast cancer cells into dormancy at bone marrow perivascular region. Cancer Research 81: 1567-1582. PMID: 33500249
- Kumar S, Gonzalez EA, Rameshwar P, Etchegaray JP. (2020). Non-Coding RNAs as Mediators of Epigenetic Changes in Malignancies. Cancers 12: 3657. PMID: 33291485
- Ferrer A, Roser CT, El-Far MH, Savanur VH, Eljarrah A, Gergues M, Kra JA, Etchegaray JP, Rameshwar P. (2020). Hypoxia-mediated changes in bone marrow microenvironment in breast cancer dormancy. Cancer Lett 488: 9-17. PMID: 32479768
- Ferrer A, Trinidad JR, Sandiford O, Etchegaray JP, Rameshwar P. (2020). Epigenetic dynamics in cancer stem cell dormancy. Cancer Metastasis Rev 39: 721-738. PMID: 32394305
- Etchegaray JP, et al., (2019). The histone deacetylase SIRT6 restrains transcription elongation via promoter-proximal pausing. Molecular Cell 75: 683-699. PMID: 31399344
- Etchegaray JP and Mostoslavsky R (2018). A sirtuin’s role in preventing senescence by protecting ribosomal DNA. J Biol Chem 293: 11251-11252.
- Ferrer CM, Alders M, Postma AV, Park S, Klein MA, Cetinbas M, Pajkrt E, Glas A, van Koningsbruggen S, Christoffels VM, Mannens MMAM, Knegt L, Etchegaray JP, Sadreyev RI, Denu JM, Mostoslavsky G, van Maarle MC, Mostoslavsky R (2018). An inactivating mutation the histone deacetylase SIRT6 causes human perinatal lethality. Genes Dev 32: 373-388.
- Choi J, Clement K, Huebner AJ, Webster J, Rose CM, Brumbaugh J, Walsh RM, Lee S, Savol A, Etchegaray JP, Gu H, Boyle P, Elling U, Mostoslavsky R, Sadreyev R, Park PJ, Gygi SP, Meissner A, Hochedlinger K (2017). DUSP9 modulates DNA hypomethylation in female mouse pluripotent stem cells. Cell Stem Cell 20: 706-719.
- Etchegaray JP, et al., (2016). Interplay between metabolism and epigenetics: a nuclear adaptation to environmental changes. Molecular Cell 62: 695-711.
- Etchegaray JP and Mostoslavsky R (2015). Cell fate by SIRT6 and TETs. Cell Cycle 14: 1-2.
- Etchegaray JP, et al., (2015). The histone deacetylase SIRT6 controls embryonic stem cell fate via TET-mediated production of 5-hydroxymethylcytosnie. Nature Cell Biology 17: 545-557.
- Etchegaray JP, et al., (2013). The histone deacetylase SIRT6: ate the crossroads between epigenetic, metabolism and disease. Curr Top Med Chem 13: 2991-3000.
- Etchegaray JP and Mostoslavsky R (2011). Energizing pluripotent gene transcription. Cell Stem Cell 9: 285-286.
- Lee HM, Chen R, Kim H, Etchegaray JP, Weaver DR, Lee C (2011). The period of the circadian oscillator is primarily determined by the balance between casein kinase 1 and protein phosphatase 1. Proc Natl Acad Sci USA 108: 16451-16456.
- Etchegaray JP, et al., (2010). Casein kinase 1 delta (CK1d) regulates period length in the mouse suprachiasmatic circadian clock in vitro. PLoS One 5(4): e10303.
- Etchegaray JP, et al., (2009). Casein kinase 1 delta regulates the pace of the mammalian circadian clock. Mol Cell Biol 29: 3853-3866.
- Etchegaray JP, et al., (2006). The polycomb group protein EZH2 is required for mammalian circadian clock function. J Biol Chem 281: 21209-21215.
- Etchegaray JP, et al., (2003). Rhythmic histone acetylation underlies transcription in the mammalian circadian clock. Nature 421: 177-182.
- Lee C, Etchegaray JP, et al., (2001). Posttranslational mechanisms regulate the mammalian circadian clock. Cell 107: 855-867.