The therapeutic potential of TLR ligands in spinal cord injury
Description:
This project investigates the effects of TLR9 and TLR7 ligands on locomotor, pain, and bladder dysfunction in mice sustaining a contusion injury. The TLR ligands are delivered intrathecally. Injury is induced by the use of the Infinite Horizon Impactor. The locomotor function is assessed by open field activity and Catwalk. Chronic pain is assessed by evaluating thermal hypersensitivity using the paw withdrawal and tail-flick tests to a thermal stimulus.
Related Publications:
- A toll-like receptor 9 antagonist improves bladder function and white matter sparing in spinal cord injury.
March 09, 2015 - Toll-like receptors in central nervous system injury and disease: a focus of the spinal cord
March 09, 2015 - A toll-like receptor 9 antagonist reduces pain hypersensitivity and the inflammatory response in spinal cord injury.
January 08, 2013
Related Faculty & Staff:
- Robert F. Heary, M.D.
- Stella Elkabes, Ph.D.
- Ayomi Ratnayake, M.S.
- Alexandra Pallottie, B.S.
- Li Ni, M.D.