Shi Lab

Shaping the epithelial cell surface with actin bundling proteins During differentiation, enterocytes build an extensive apical array of microvilli known as the brush border, which serves to amplify the plasma membrane surface area available for nutrient absorption. In addition to serving as the sole site of nutrient uptake, brush border microvilli also provide an anchoring point for the glycocalyx and regulate interactions with luminal microbes. An … Read More

“Breaking Speed and Resolution Limitations of High-Speed AFM for Membrane Protein Structure-Function Analysis” Simon Scheuring1,2,* 1 Weill Cornell Medicine, Department of Anesthesiology, 1300 York Avenue, New York, NY-10065, USA. 2 Weill Cornell Medicine, Department of Physiology and Biophysics, 1300 York Avenue, New York, NY-10065, USA High-speed atomic force microscopy (HS-AFM) is a powerful technique that … Read More

Condensate Biology at the Synapse  Brain functioning critically relies on neuronal communication that mainly occurs by chemical signaling at the specialized contacts known as synapses. At synapses, messenger molecules are packed into synaptic vesicles (SVs), which are secreted upon the arrival of an action potential. For neuronal signaling to persist, synapses have to maintain an … Read More

Electronic and molecular approaches for neural recording: deciphering the brain in space and time Resolving neuronal activity in space and time is a long-sought capability in neuroscience, which is, however, still hard to achieve using existing technologies. In this talk, I will share with the audience our strategies toward this goal via innovations at the device … Read More