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Mechanics of Biomolecular Assemblies

  – where Chemistry meets Physics and Biology!

 

Welcome!

The Shi lab combines biophysical, chemical, and optogenetic tools to study the properties of biomolecular assemblies such as protein condensates and cell membranes. We aim to understand the material and mechanical properties of biomolecular assemblies. Our research will shed light on how material properties mediate the biological functions of cell membranes and biomolecular condensates.

We are currently looking for motivated students and postdocs: 1) to study the material properties biomolecular condensates that are relevant to neurodegeneration; 2) to investigate how local mechanical and geometrical cues on the cell membrane affect the behavior of membrane proteins; 3) to understand how interactions with either cytoskeleton or extracellular matrix affect the dynamics of cell membranes. Postdocs please apply here. Contact us for more details!

News

Targeting drugs to the nucleus

Shilong worked together with a team led by Rohin from Janson Zhang’s lab to test the idea of using C60-cycolodextrin as drug delivery systems. Unexpectedly, one of the systems was able to efficiently target drug (doxorubicin) molecules to the nucleus of (HeLa) cells! Read the full story on Nanoscale, great team work!  

Reid Award and Zhou Family Fellowship

Congratulations to Huan for winning the Reid Award, which recognizes Rutgers Chemistry students with the highest honors for exceptional performance in research! Huan was also selected to receive the Zhou family fellowship through a generous gift by alumni, Drs. Quan Zhou and Xiaohua Zhang!! Good job, Huan!! Check out more information about the Reid Award … Read More

The Shi lab will be presenting at the 2022 BPS annual meeting

The Shi lab will be well-represented at the 2022 BPS meeting! Huan will talk about how to quantify the material properties of protein condensates at the platform for Liquid-Liquid Phase Separation II (1487-Plat, 5:15 pm, Tuesday, 2/22). Zheng will discuss the mechanics of cell membranes at the Membrane Tension symposium (4 pm, Monday, 2/21). Our … Read More

Looking for Postdoc!

We are looking for a motivated postdoc to study one of the following research topics:  1) to study the material properties biomolecular condensates that are relevant to neurodegeneration; 2) to investigate how physical cues on the cell membrane affect the subcellular behavior of membrane proteins; 3) to understand how interactions with either cytoskeleton or extracellular … Read More

Zheng gave a talk at Yale

Zheng had a fun day (virtually) visiting the cell biology department of Yale. Learned lots of cool science and spoke about our recent findings on cell membranes and protein condensates! Check out details here.

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