Papers

Two of our recent findings on condensates were posted on bioRxiv! In the first one, Huan made a surprising discovery that the excitation of fluorescently tagged proteins leads to condensate-mediated … Read More

As part of her thesis, Huan systematically reviewed the rheology and interfacial properties of biomolecular condensates. In addition to summarizing quantitative measurements in the literature, we also tried point out … Read More

In collaboration with Jie Xu’s lab, Yiling studied how a protein called “NINJ1” regulates the rupture of cell plasma membranes. We found that having more NINJ1 drastically reduces the lysis … Read More

In collaboration with Cliff Brangwynne and Howard Stone’s groups, Holly, James, and Huan studied the mechanics of the nucleolus – the very core of a eukaryotic cell and a multi-layered … Read More

Several papers from the lab were published in the past few months. In collaboration with the labs of Dragomir Milovanovic, Zhiping Pang, Jean Baum, and Conor McClenaghan, Huan and Mengying … Read More

Shilong and Zheng wrote a book chapter, detailing the steps to quantify cell membrane protrusions (and the sorting of proteins on them) using simple widefield fluorescence images. Read it here!

In collaboration with Howard Stone’s lab, we developed and tested a calibration-free model to analyze the micropipette aspiration of liquid condensates!

Shilong found that the shape of cell membrane directly regulates the distribution of Piezo1, a widely expressed mechanosensitive ion channel, within a cell. Piezo1 may flatten upon activation and can … Read More