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Curvature and Mechanosensing

Shilong found that the shape of cell membrane directly regulates the distribution of Piezo1, a widely expressed mechanosensitive ion channel, within a cell. Piezo1 may flatten upon activation and can mechanically inhibit membrane dynamics. Read the paper on Nature Communications!

This is a great team work with important contributions from Steven, Boxuan, Huan, and Matthew. Congratulations!

Many thanks to our collaborators from the labs of Charles Cox, Wenting Zhao, and Medha Pathak!