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Zhaohui Feng, PhD

Division of Radiation Cancer Biology

Zhaohui Feng, MD, PhD, is a tenured Professor in the Department of Radiation Oncology of Rutgers Cancer Institute of New Jersey at Rutgers University. Dr. Feng received his MD and PhD from Zhejiang University School of Medicine. Dr. Feng completed his postdoctoral training at New York University Medical School focusing on DNA damage and repair and at the University of Medicine and Dentistry of New Jersey focusing on tumor suppressor p53 signaling pathway. Since 2008, Dr. Feng has been a faculty member at Rutgers Cancer Institute of New Jersey. A major research interest of Dr. Feng’s group is to study the role and mechanism of tumor suppressor p53 and gain-of-function mutant p53 in cancer. In addition, Dr. Feng studies the role and mechanism of metabolic reprogramming in cancer and how metabolic reprogramming in cancer can be targeted for therapy. The research conducted in Dr. Feng’s laboratory has been supported by NIH, DoD, and the New Jersey Commission on Cancer Research (NJCCR), and New Jersey Health Foundation.

 

Publications

  1. Chang C, Wang J, Zhao Y, Liu J, Yang X, Yue X, Wang H, Zhou F, Inclan-Rico J, Ponessa J, Xie P, Zhang L, Siracusa M, Feng Z (co-corresponding), Hu W. (2021) Tumor suppressor p53 regulates intestinal type 2 immunity. Nature Communication. 2021;12(1):3371. PMID: 34099671
  2. Liu J, Zhang C, Wu H, Sun XX, Li Y, Huang S, Yue X, Lu SE, Shen Z, Su X, White E, Haffty BG, Hu W, Feng Z. Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression. J Clin Invest. 2020; 130(6):3253-3269. PMID: 32478681.
  3. Zhao Y, Wu L, Yue X, Zhang C, Wang J, Li J, Sun X, Zhu Y, Feng Z (co-corresponding), Hu W. A polymorphism in the tumor suppressor p53 affects aging and longevity in mouse models. Elife. 2018, doi: 10.7554/eLife.34701. PMID: 29557783.
  4. Yue X, Zhang C, Zhao Y, Liu J, Lin AW, Tan V, Drake JM, Liu L, Boateng MN, Li J, Feng Z* (co-corresponding), Hu W*. Gain-of-function mutant p53 activates small GTPase Rac1 through SUMOylation to promote tumor progression. Genes & Development. 2017, 31: 1641-54. PMID: 28947497
  5. Liu J, Zhang C, Zhao Y, Yue X, Wu H, Huang S, Chen J, Tomsky K, Xie H, Khella K, Gatza M, Xia D, Gao J, White E, Haffty BG, Hu W, Feng Z. (2017) Parkin targets HIF-1α for ubiquitination and degradation to inhibit breast tumor progression. Nature Communications. 2017;8(1):1823. PMID: 29180628
  6. Zhang C, Liu J, Huang G, Zhao Y, Yue X, Wu H, Li J, Zhu J, Shen Z, Haffty BG, Hu W, Feng Z. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes & Development. 2016; 30(17):1956-70. PMID: 27664236
  7. Zhang C, Liu J, Zhao Y, Yue X, Zhu Y, Wang X, Wu H, Blanco F, Li S, Bhanot G, Haffty BG, Hu W, Feng Z. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. eLife. 2016; 5:e10727. PMID: 26751560
  8. Yu H, Yue X, Zhao Y, Li X, Wu L, Zhang C, Liu Z, Lin K, Xu-Monette Z, Young K, Liu J, Shen Z, Feng Z*, Hu W*. LIF negatively regulates tumor suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. Nature Communications. 2014; 5:5218 doi:10.1038/ncomms6218. (PMC4203416)
  9. Liu J, Zhang C, Wang XL, Ly P, Belyi V, Xu-Monette ZY, Young KH, Hu W, Feng Z. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell death and differentiation. 2014; 21(11):1792-804. PMID: 25146927
  10. Zheng T, Wang J, Zhao Y, Zhang C, Lin M, Wang X, Yu H, Liu L, Feng Z*, Hu W*. Spliced MDM2 isoforms promote mutant p53 accumulation and gain-of-function in tumorigenesis. Nature Communications. 2013; 4:2996 doi: 10.1038/ncomms3996. (PMC3960723)
  11. Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X, Lin M, Yu H, Liu L, Levine A, Hu W, Feng Z. Tumor-Associated Mutant p53 Drives the Warburg Effect. Nature Communications. 2013; 4:2935 doi: 10.1038/ncomms3935.
  12. Feng Z, Liu L, Zhang C, Zheng T, Wang J, Lin M, Zhao Y, Wang X, Levine A, Hu W. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. PNAS. 2012; 109:7013-7018. PMC3345015
  13. Zhang C, Lin M, Wu R, Wang X, Yang B, Levine AJ, Hu W, Feng Z. Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect. PNAS. 2011; 108(39):16259-64.
  14. Hu W, Chan CS, Wu R, Zhang C, Sun Y, Song JS, Tang LH, Levine AJ, Feng Z. Negative regulation of tumor suppressor p53 by microRNA miR-504. Molecular cell. 2010; 38(5):689-99. PMID: 20542001
  15. Hu W, Zhang C, Wu R, Sun Y, Levine A, Feng Z. Glutaminase 2, a novel p53 target gene regulating energy metabolism and antioxidant function. PNAS. 2010; 107(16):7455-60.

A complete list of publications by Dr. Zhaohui Feng