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Our lab studies how human gut microbiome regulates intestinal epithelial biology and mucosal immunology. The team is interested in understanding the fundamental mechanisms that affect our digestive health and diseases.
Congratulations to Aster and Sheila for their recently published study in EMBO J. “Reactive oxygen species stimulate Paneth cell plasticity and diminish antimicrobial function”
ROS stimulates Paneth cell plasticity
Paneth cell lineage tracing in organoids reveal cellular plasticity upon ROS challenge.
Congratulations to Jared’s Gut Microbes paper
Transplant of microbiota from Crohn’s disease patients to germ-free mice results in colitis
Congratulations to Jason’s JBC paper
Intestinal lysozyme engagement of Salmonella Typhimurium stimulates the release of barrier-impairing InvE and Lpp1
Image of this month
Human ileum organoids
Imaged by Aster
Congratulations to Ivor Joseph’s EMBO Rep paper
RAB11A and RAB11B control mitotic spindle function in intestinal epithelial progenitor cells
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Mouse enteroid & immune cells
Imaged by Jared
Congratulations to Iyshwarya and Sheila’s EMBO J. paper
Infection and inflammation stimulate expansion of a CD74+ Paneth cell subset to regulate disease progression