My lab focuses on the function of transcription factor (TF) networks during cell fate transitions in the early stages of cancer development as well as during aging of the immune system. We use high-throughput sequencing, genome editing, cell isolation and computational approaches to build TF network models. Using this information, we target transcription factors to manipulate cell fates and obtain prognostic epigenetic information to guide clinical treatment.
Current projects in the lab:
- Interplay between cellular reprogramming and senescence during the early stages of breast cancer development.
- Escape from oncogene-induced senescence in colorectal cancer.
- Dissection of senescence and aging effects in gene regulatory networks of monocytes and CD8 T cells.