Senescent effector CD8+ T cells are dysfunctional and enriched in disease
Our new preprint characterizing senescent effector CD8+ T cells is out now at bioRxiv. Check it out at: https://www.biorxiv.org/content/10.64898/2025.12.16.694716v1.full
TF Network Dynamics
Age-independent and targetable transcription factor networks regulating CD8+ T cell senescence in aging humans published in Cell Reports
Our new paper, published in Cell Reports, provides a comprehensive foundation of the gene regulatory mechanisms controlling senescence in CD8+ T cells in humans and provides new avenues for the … Read More
Our new pre-print on the senescence phenotype of effector CD8+ T cells is available on bioRxiv.
Our new pre-print on the characterization of senescence in effector CD8+ T cells and its implications to aging and immunotherapy is out on bioRxiv. Check it out at: https://www.biorxiv.org/content/10.1101/2025.01.17.633634v1
Epigenetic regulation of senescence in CD8+ T cells; pre-print out on bioRxiv
Our new pre-print on the transcription factor networks that regulate senescence of CD8+ T cells in aging humans is out on bioRxiv. Check it out at: https://www.biorxiv.org/content/10.1101/2025.01.17.633634v1
Transcription factor network dynamics during the commitment to oncogene-induced senescence published in Frontiers in Epigenetics and Epigenomics
Our most recent paper is out at Frontiers in Epigenetics and Epigenomics. Check it out at: https://doi.org/10.3389/freae.2024.1423454
NIH/NIGMS MIRA ESI R35 awarded to study the epigenetic mechanisms of senescence in osteoarthritis and liver fibrosis
The laboratory received a 5-year award from the National Institute of General Medical Sciences of the National Institutes of Health to define and manipulate the gene regulatory networks that lead … Read More
Award from the American Federation for Aging Research to study monocyte senescence
Announcing a recent award from the American Federation for Aging Research to support research on monocyte senescence during aging in humans in our lab. #AFAR #senescence #epigenetics #genomics https://www.afar.org/grantee-profiles/ricardo-martinez-zamudio
Commentary on Cell Genomics paper
A new article on Cancer Cytogenetics comments on our recent #CellGenomics paper escape on oncogene-induced senescence in cancer development. Cheers to Bryn Nelson and William Faquin for a really interesting read.
Our Cell Genomics paper was featured on CURE magazine
Our recent work published in Cell Genomics (https://www.cell.com/cell-genomics/fulltext/S2666-979X(23)00059-9 ) was the subject of a piece on CURE magazine. Cheers to Alex Biele at CURE for making the technicalities of our work … Read More
Escape from oncogene-induced senescence is controlled by POU2F2 and memorized by chromatin scars published in Cell Genomics
Our new publication is out at Cell Genomics. Check it out at: https://www.cell.com/cell-genomics/fulltext/S2666-979X(23)00059-9