Quantifying cell membrane protrusions
Shilong and Zheng wrote a book chapter, detailing the steps to quantify cell membrane protrusions (and the sorting of proteins on them) using simple widefield fluorescence images. Read it here!
Papers
New model for aspirating condensates
In collaboration with Howard Stone’s lab, we developed and tested a calibration-free model to analyze the micropipette aspiration of liquid condensates!
Curvature and Mechanosensing
Shilong found that the shape of cell membrane directly regulates the distribution of Piezo1, a widely expressed mechanosensitive ion channel, within a cell. Piezo1 may flatten upon activation and can … Read More
Tension along an axon
Our study on the membrane of neuronal axons is now published on Science Advances! We found that membrane tension propagates at a surprisingly fast speed (20 microns/s!) along the axons of … Read More
Targeting drugs to the nucleus
Shilong worked together with a team led by Rohin from Janson Zhang’s lab to test the idea of using C60-cycolodextrin as drug delivery systems. Unexpectedly, one of the systems was … Read More
Huan’s paper in the news
Huan’s paper on quantifying the surface tension and viscosity of protein condensates has been picked up by a wide range of news outlets, including: EurekAlert!, ScienceDaily, News wise, Phys.org, Neuroscience … Read More
Aspirating protein droplets
Huan’s paper on using micropipette aspiration to quantify the surface tension and viscosity of liquid protein condensates is now published on the first issue of Biophysical Reports! She showed that … Read More