Peer reviewed research article, “Investigating underlying human immunity genes, implicated diseases, and their relationship with the COVID-19“, by Drs. Ahmed, Renart, and Zeeshan, has been selected among top five articles with the highest readership in year 2022.
Dr. Ahmed’s article ranked top as the most read Research Article of the year 2022. This article is about investigating the genetic susceptibility and variations among the DNA of healthy and COVID-19 diseased individuals.
The quest to establish an understanding of the genetics underlying COVID-19 is a central focus of life sciences today. COVID-19 is triggered by SARS-CoV-2, a single-stranded RNA respiratory virus. Several clinical-genomics studies have emerged positing different human gene mutations occurring due to COVID-19. A global analysis of these genes was conducted targeting major components of the immune system to identify possible variations likely to be involved in COVID-19 predisposition. Gene-variant analysis was performed on whole-genome sequencing samples collected from diverse populations. ACE2, TMPRSS4, TMPRSS2, SLC6A20 and FYCOI were found to have functional implications and TMPRSS4 may have a role in the severity of clinical manifestations of COVID-19.
– Ahmed Z., Renart., E., Zeeshan, S. (2022). Investigating underlying human immunity genes, implicated diseases, and their relationship with the COVID-19. Personalized Medicine. 19(3), 229–250. PMID: 35261286
– Jones S. (2023). Content highlights of the year: a look over 2022 at Personalized Medicine. Personalized medicine, 10.2217/pme-2022-0135. Advance online publication. PMID: 36598111