Courses Taught
Spring 2023
14:125:306: Biomedical Kinetics and Thermodynamics
Mondays and Wednesdays, 2:00 – 3:20 pm, RWH-102
Syllabus
| Week | Date | Topic | Reading (Tinoco) |
| 1 | Jan. 18 | Introduction; forms of energy | Chapter 1 |
| 2 | Jan. 23 | First law of thermodynamics | Chapter 2 |
| Jan. 25 | Calculation of thermodynamic properties | ↓ | |
| 3 | Jan. 30 | Entropy and the second law of thermodynamics | Chapter 3 |
| Feb. 1 | Calculations with entropy and free energy | ↓ | |
| 4 | Feb. 6 | Free energy and chemical potential | Chapter 4 |
| Feb. 8 | Thermodynamic activity | ↓ | |
| 5 | Feb. 13 | Protein biochemistry | Chapter 12 |
| Feb. 15 | Protein titration and folding | ↓ | |
| 6 | Feb. 20 | Protein aggregation | ↓ |
| Feb. 22 | Nucleic acid structure and hybridization | Chapter 5 | |
| 7 | Feb. 27 | Midterm Exam 1 | |
| Mar. 1 | Design of primers for polymerase chain reaction | Chapter 4 | |
| 8 | Mar. 6 | Physical equilibria: solubility, dialysis and ligand-receptor binding | Chapter 6 |
| Mar. 8 | Ligand-receptor binding: Langmuir adsorption | Chapter 5 | |
| Mar. 11-19 | No class – Enjoy Spring Break!!! | ||
| 9 | Mar. 20 | Ligand-receptor binding: Scatchard and Hill analyses | Chapter 5 |
| Mar. 22 | Colligative properties | Chapter 6 | |
| 10 | Mar. 27 | Electrochemistry | Chapter 7 |
| Mar. 29 | Active transport | ↓ | |
| 11 | Apr. 3 | Midterm Exam 2 | |
| Apr. 5 | Kinetic analysis I | Chapter 9 | |
| 12 | Apr. 10 | Kinetic analysis II | ↓ |
| Apr. 12 | Enzyme kinetics I | Chapter 10 | |
| 13 | Apr. 17 | Enzyme kinetics II | ↓ |
| Apr. 19 | Biosensors | ||
| 14 | Apr. 24 | Pharmacokinetics | Fournier, Ch.5 |
| Apr. 26 | Pharmacodynamics | ↓ | |
| 15 | May 1 | Epidemiology | |
| 16 | May 9 | Final Exam (12:00 -3:00 PM) |
Fall 2022
16:155:531: Biochemical Engineering
Wednesdays, 5:40 – 8:40 pm, SEC-205
Syllabus
| Module | Date | Topic | Chapter | Guest/discussion |
| 1 | Sept. 7 | Introduction | 1 | |
| 2 | Sept. 14 | Protein structure and stability | 2.2.1 | Prof. Schuster |
| 3 | Sept. 21 | Enzymes | 3 | Prof. Chundawat |
| 4 | Sept. 28 Oct. 5 | Cell growth kinetics | 6, 7 | |
| Oct. 19 | Quiz 1 (Modules 1-4) | |||
| 5 | Oct. 12 | Bioreactors | 9 | |
| 6 | Oct. 26 | Aeration and Scale-up | 10 | Dr. Brieva (Resilience) |
| Design Study (Modules 5-6) | ||||
| 7 | Nov. 2 | Genetic engineering and cell line development | 8,14 | |
| 8 | Nov. 9 | Metabolic engineering | 5, 14 | Prof. Zhang |
| 9 | Nov. 16 | Bioseparations | 11 | |
| Nov. 30 | Quiz 2 (Modules 7-9) | |||
| 10 | Dec. 7 | Monoclonal antibodies | ||
| 11 | Dec. 14 | Cell and gene therapies | 15 | |
| Integrative Study (emphasizing Modules 10-11) |
Fall 2021
16:125:590: Drug Delivery Fundamentals and Applications
16:155:544: Pharmaceutical Organic Nanotechnology
Wednesdays, 5:00 – 8:00 pm, BME-116
Syllabus
| Week | Class date | Topic |
| Drug Delivery Barriers and Formulations | ||
| 1 | Sept. 1 | Introduction and Overview |
| 2 | Sept. 8 | Pharmacokinetics |
| 3 | Sept. 15 | Transport in Tissues |
| 4 | Sept. 22 | Cellular and Intracellular Transport of Drugs |
| 5 | Sept. 29 | Drug Conjugates and Nanoparticles |
| 6 | Oct. 6 | Pharmaceutical Dosage Forms |
| 8 | Oct. 20 | Review and Exam 1 |
| Engineered Drug Delivery Systems | ||
| 7 | Oct. 13 | Controlled Release Drug Delivery Systems |
| 9 | Oct. 27 | Physiologically Targeted Drug Delivery |
| 10 | Nov. 3 | Precision Targeted Drug Delivery |
| Applications | ||
| 11 | Nov. 10 | Transdermal Drug Delivery |
| 12 | Nov. 17 | GI and Pulmonary Delivery |
| Nov. 24 | No class – Happy Thanksgiving! | |
| 13 | Dec. 1 | Gene and Oligonucleotide Delivery – part I |
| 14 | Dec. 8 | Gene and Oligonucleotide Delivery – part II |
| 15 | Term Project Submission and Peer Review |
Previous Courses Taught
2001 Instructor, “Enzyme Engineering” (155:534)
Enrollment: 5 students
2001-2004, 2022-2023 (6x) Instructor, “Biomedical Kinetics and Thermodynamics” (125:314; 125:306)
Cumulative enrollment: 339 students
2001-2002 (2x) Instructor, “Chemical Engineering Analysis I” (155:201)
Cumulative enrollment: 80 students
2002 Co-instructor, “Introduction to Biomedical Engineering” (125:201), 8 lectures
Enrollment: 85 students
2003-2008 (6x) Co-instructor, “BME Measurements and Analysis Laboratory” (125:314), 2 lectures + laboratories
Cumulative enrollment: ~400 students
2004-2007 (4x) Instructor, “Advanced Chemical Engineering Thermodynamics” (155:511)
Cumulative enrollment: 55 students
2005-2010 (4x) Instructor, “Integrative Molecular and Cellular Bioengineering” (125:584)
Cumulative enrollment: 39 students
2008 Lead Instructor, “BME Measurements and Analysis Laboratory” (125:315)
Enrollment: 72 students
2008 Instructor, “Preparing Future Faculty II” (125:632)
Enrollment: 11 students
2010 Instructor, “Preparing Future Faculty I” (125:631)
Enrollment: 9 students
2009, 2011 (2x) Instructor, “Pharmaceutical Organic Nanotechnology (Drug Delivery)” (155:544)
Cumulative enrollment: 29 students
2009, 2011 (2x) Instructor, “Nanotechnology in Cancer” (01:090:101)
Cumulative enrollment: 40 students
2009-2011 (3x) Instructor, “Chemical Engineering Kinetics” (155:411)
Cumulative enrollment: 183 students
2012-21 (8x) Instructor, “Drug Delivery Principles and Applications” (125:590/155:544)
Cumulative enrollment: 230 students
2012-14 (3x) Instructor, “Introduction to Biochemical Engineering” (155:411)
Cumulative enrollment: 269 students
2013-18 (6x) Instructor, “Teaching in the Engineering Curriculum” (155:605)
Cumulative enrollment: 60 students
2016-17 (2x) Instructor, “Biological Foundations of Chemical Engineering” (155:210)
Cumulative enrollment: 234 students
2018-20 (2x) Instructor, “Opportunities and Challenges in Nanomedicine” (090:101)
Cumulative enrollment: 36 students
2019-22 (3x) Instructor, “Biochemical Engineering” (155:531)
Cumulative enrollment: 50 students
2021 Instructor, “Clinical Practicum” (125:628)
Enrollment: 36 students
2021 Co-Instructor, “Integrative Molecular and Cellular Bioengineering” (125:584)
Enrollment: 33 students