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Spring 2022

14:125:306: Biomedical Kinetics and Thermodynamics

Wednesdays, 3:50 – 5:10 pm, SEC-210

Syllabus (subject to change)

Week Date Topic Reading (Tinoco)
1 Jan. 19 Introduction; forms of energy Chapter 1
2 Jan. 24 First law of thermodynamics Chapter 2
Jan. 26 Calculation of thermodynamic properties
3 Jan. 31 Entropy and the second law of thermodynamics Chapter 3
Feb. 2 Calculations with entropy and free energy
4 Feb. 7 Free energy and chemical potential Chapter 4
Feb. 9 Thermodynamic activity
5 Feb. 14 Protein biochemistry and titration Chapter 12
Feb. 16 Protein folding, aggregation and solubility
6 Feb. 21 Statistical thermodynamics Chapter 5
Feb. 23 Nucleic acid structure and hybridization
7 Feb. 28 Midterm Exam 1
Mar. 2 Design of primers for polymerase chain reaction Chapter 4
8 Mar. 7 Physical equilibria: solubility, dialysis and ligand-receptor binding Chapter 6
Mar. 9 Ligand-receptor binding: statistical thermodynamics Chapter 5
Mar. 14-19 No class – Enjoy Spring Break!!!
9 Mar. 21 Ligand-receptor binding: Scatchard and Hill analyses Chapter 5
Mar. 23 Covid-19 diagnostic principles
10 Mar. 28 Electrochemistry Chapter 7
Mar. 30 Active transport
11 Apr. 4 Kinetic analysis I Chapter 9
Apr. 6 Kinetic analysis II
12 Apr. 11 Midterm Exam 2
Apr. 13 Enzyme kinetics I Chapter 10
13 Apr. 18 Enzyme kinetics II
Apr. 20 Biosensors
14 Apr. 26 Pharmacokinetics Fournier, Ch.5
Apr. 28 Pharmacodynamics
15 May 2 Review (last day of class)
16 May 11 Final Exam (12:00 – 3:00 PM)

Fall 2021

16:125:590: Drug Delivery Fundamentals and Applications

16:155:544: Pharmaceutical Organic Nanotechnology

Wednesdays, 5:00 – 8:00 pm, BME-116

Syllabus

Week Class date Topic
    Drug Delivery Barriers and Formulations
1 Sept. 1 Introduction and Overview
2 Sept. 8 Pharmacokinetics
3 Sept. 15 Transport in Tissues
4 Sept. 22 Cellular and Intracellular Transport of Drugs
5 Sept. 29 Drug Conjugates and Nanoparticles
6 Oct. 6 Pharmaceutical Dosage Forms
8 Oct. 20 Review and Exam 1
  Engineered Drug Delivery Systems
7 Oct. 13 Controlled Release Drug Delivery Systems
9 Oct. 27 Physiologically Targeted Drug Delivery
10 Nov. 3 Precision Targeted Drug Delivery
  Applications
11 Nov. 10 Transdermal Drug Delivery
12 Nov. 17 GI and Pulmonary Delivery
Nov. 24 No class – Happy Thanksgiving!
13 Dec. 1 Gene and Oligonucleotide Delivery – part I
14 Dec. 8 Gene and Oligonucleotide Delivery – part II
15 Term Project Submission and Peer Review

Previous Courses Taught

2001 Instructor, “Enzyme Engineering” (155:534)
Enrollment: 5 students

2001-2004 (4x) Instructor, “Biomedical Thermodynamics and Kinetics” (125:314)
Cumulative enrollment: 195 students

2001-2002 (2x) Instructor, “Chemical Engineering Analysis I” (155:201)
Cumulative enrollment: 80 students

2002 Co-instructor, “Introduction to Biomedical Engineering” (125:201), 8 lectures
Enrollment: 85 students

2003-2008 (6x) Co-instructor, “BME Measurements and Analysis Laboratory” (125:314), 2 lectures + laboratories
Cumulative enrollment: ~400 students

2004-2007 (4x) Instructor, “Advanced Chemical Engineering Thermodynamics” (155:511)
Cumulative enrollment: 55 students

2005-2010 (4x) Instructor, “Integrative Molecular and Cellular Bioengineering” (125:584)
Cumulative enrollment: 39 students

2008 Lead Instructor, “BME Measurements and Analysis Laboratory” (125:315)
Enrollment: 72 students

2008 Instructor, “Preparing Future Faculty II” (125:632)
Enrollment: 11 students

2010 Instructor, “Preparing Future Faculty I” (125:631)
Enrollment: 9 students

2009, 2011 (2x) Instructor, “Pharmaceutical Organic Nanotechnology (Drug Delivery)” (155:544)
Cumulative enrollment: 29 students

2009, 2011 (2x) Instructor, “Nanotechnology in Cancer” (01:090:101)
Cumulative enrollment: 40 students

2009-2011 (3x) Instructor, “Chemical Engineering Kinetics” (155:411)
Cumulative enrollment: 183 students

2012-20 (7x) Instructor, “Drug Delivery Principles and Applications” (125:590/155:544)
Cumulative enrollment: 193 students

2012-14 (3x) Instructor, “Introduction to Biochemical Engineering” (155:411)
Cumulative enrollment: 269 students

2013-18 (6x) Instructor, “Teaching in the Engineering Curriculum” (155:605)
Cumulative enrollment: 60 students

2016-17 (2x) Instructor, “Biological Foundations of Chemical Engineering” (155:210)
Cumulative enrollment: 234 students

2018-20 (2x) Instructor, “Opportunities and Challenges in Nanomedicine” (090:101)
Cumulative enrollment: 36 students

2019-20 (2x) Instructor, “Biochemical Engineering” (155:531)
Cumulative enrollment: 38 students

2021 Instructor, “Clinical Practicum” (125:628)
Enrollment: 36 students

2021 Co-Instructor, “Integrative Molecular and Cellular Bioengineering” (125:584)
Enrollment: 33 students